Macrophage activation syndrome in a patient with adult-onset Still’s disease following first COVID-19 vaccination with BNT162b2Case Report Published on 2021-12-282022-10-28 Journal: BMC Rheumatology [Category] COVID-19, [키워드] activate Activation Adult-onset Still’s disease adverse events Autoimmune BNT162b2 Case report ChAdOx1 nCoV-19 Complication conditions COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines described disease dose female ferritin level immune cells Influenza interferon knowledge macrophage activation syndrome MONITOR mortality rate mRNA mRNA vaccine nucleic acid Occurrence of BNT162b2 pathogen-associated molecular pattern Patient positive potentially life-threatening pro-inflammatory cytokine receiving safety profile SARS-CoV-2 vaccination shown supplementary material syndrome thought Toll-like receptor vaccination Vaccine reaction viral infection Viral vector vaccine [DOI] 10.1186/s41927-021-00237-9 PMC 바로가기 [Article Type] Case Report
Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patientsToll-유사 수용체 7의 희귀 변이는 COVID-19 환자에서 기능 손상 및 사이토카인 매개 신호의 하향 조절을 초래합니다Brief Communication Published on 2021-12-242022-09-10 Journal: Genes and Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] ACOD1 affected antiviral responses Cell Chronic diseases component COVID-19 patient CXCL10 Cytokines decrease downregulation failure functional Genes genetics hypomorphic IFIT2 IFN IFNα IFNγ imiquimod immune responses immunology impairment innate antiviral responses innate immune response innate immune responses interferons loss-of-function male men mononuclear cell mononuclear cells mRNA level mRNA levels Pathogens pathway Patient performed Peripheral blood Peripheral blood mononuclear cells pro-inflammatory cytokine pro-inflammatory cytokines recognize responses responsible RNA sequencing RSAD2 SARS-CoV-2 severe COVID-19 Signaling single-stranded RNA virus Stimulation TLR TLR7 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors Transcriptome triggering type I upregulation variant variants Variation variety viruses was performed [DOI] 10.1038/s41435-021-00157-1 PMC 바로가기 [Article Type] Brief Communication
Potential Role of Colchicine in Combating COVID-19 Cytokine Storm and Its Ability to Inhibit Protease Enzyme of SARS-CoV-2 as Conferred by Molecular Docking AnalysisReview Published on 2021-12-232022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] Ability addition Analysis Anti-inflammatory anti-inflammatory activity antiviral activity ASN142 binding boceprevir Colchicine complex complexes Coronavirus disease 2019 COVID-19 COVID-19 cytokine storm Cys145 Cytokine storm docking Donor enzyme Evidence global pandemic Glu166 Gly143 hallmark Health hydrogen bonds hydrophobic interaction improve clinical outcomes indicated inhibiting Interaction life threatening management manifestation manifested Mild symptom molecular docking Pathways Potential pro-inflammatory cytokine Probability protease Protease inhibitor provided RdRP reduce respiratory RNA polymerase RNA-dependent RNA polymerase role SARS-CoV-2 Seven severity stability storm the cytokine storm the disease [DOI] 10.3390/medicina58010020 PMC 바로가기 [Article Type] Review
Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beatingBiochemistry Published on 2021-12-202022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 48 hours abrogate Affect arrhythmia cardiomyocyte cause Cell cell death chaperone condition consequence COVID COVID-19 patients described detrimental effect disrupt downregulating dysfunction expressed expression Frequency infect inhibition investigated IPSC myocarditis number of infected prevented pro-inflammatory cytokine Protective effects receptor reduced reducing reported SARS-CoV-2 SARS-COV-2 infection sigma-1 receptor survival therapeutic potential therapeutic target triggered viral particle [DOI] 10.7717/peerj.12595 PMC 바로가기 [Article Type] Biochemistry
Sex differences in the immune response to acute COVID-19 respiratory tract infectionResearch Published on 2021-12-202022-10-28 Journal: Biology of Sex Differences [Category] COVID-19, [키워드] acute COVID-19 Adaptive immune response age anti-inflammatory cytokine B cell blood sample circulating neutrophil Cohort cohorts collected conducted control group control patient COVID COVID-19 cytokine Cytometry demographics diagnosed with COVID-19 disease severity ELISA Ethnic groups female Female patients females Flow group Hospital admission hospitalized patient IL-10 IL-6 IL-8 immune response implicated increasingly infection rate inflammatory mediator Inflammatory response innate immune response leukocyte leukocytes male males MCP-1 mechanism men Mild MIP-1β moderate monocyte mortality rate Patient plasma pro-inflammatory cytokine respiratory tract infection response Result robust severe disease severity Sex difference significantly higher significantly increased significantly more supplementary material the disease three group were used [DOI] 10.1186/s13293-021-00410-2 PMC 바로가기 [Article Type] Research
Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for PathogenicityArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus [DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article
Immune dysfunction in COVID-19 and judicious use of antirheumatic drugs for the treatment of hyperinflammationCOVID-19의 면역 기능 장애 및 과염증 치료를 위한 항류마티스 약물의 현명한 사용Review Published on 2021-12-172022-09-10 Journal: Turkish Journal of Medical Sciences [Category] SARS, 치료제, [키워드] administer Administered advanced age affected Antiviral cause of death caused China coronavirus Coronavirus 2019 coronavirus disease Coronavirus disease-19 Corticosteroid Corticosteroids Course COVID-19 cytokine Cytokine storm Cytokines death disease disease course dose drug dysfunction dysregulated earth Economy effective feature global pandemic globe heterogenous hyperinflammation IL-6 immune deficiency immune response immune system immunomodulatory Immunosuppression impairing infected individuals infected patient infected patients Inflammation Inflammatory diseases interferon interferon response interleukin interleukin (IL)-1 life life-threatening Lower respiratory tract morbidity and mortality neutralization Novel coronavirus outcomes pandemic patient population pro-inflammatory cytokine pro-inflammatory cytokines Prognosis respiratory responsible rheumatology SARS-CoV-2 selective Severe infection single person spread to syndrome the disease Treatment Vaccines Viral viral clearance Wuhan [DOI] 10.3906/sag-2110-179 PMC 바로가기 [Article Type] Review
Inflammasomes and SARS-CoV-2 InfectionReview Published on 2021-12-142022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] “cytokine storm” activate Activation Adaptive immune response affected caused coronavirus COVID-19 COVID-19 patient Cytokines develop disease form function gasdermin D IL-18 IL-1β induce Inflammasome inflammasomes Inflammatory cell death influenza A virus innate immune response innate immune system Innate immunity Local majority mild respiratory symptoms mRNA vaccine multiple organ people with COVID-19 pro-inflammatory cytokine pro-inflammatory cytokines Protective Protein protein complex pyroptosis recent SARS-CoV-2 SARS-COV-2 infection secretion severe COVID-19 severe disease Structure systemic inflammation virus infection worldwide pandemic [DOI] 10.3390/v13122513 PMC 바로가기 [Article Type] Review
Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in AsthmaImiquimod는 인터페론 반응을 높이고 ACE2 및 천식에서 인간 기관지 상피의 염증 반응을 감소시킵니다Immunology Published on 2021-12-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] ACE2 ACE2 expression analyses Analysis analyzed Anti-inflammatory Anti-viral anti-viral cytokine anti-viral cytokines anti-viral drug Anti-viral treatment Asthma asthmatic Asthmatic patients baseline bronchial bronchial epithelial cell COVID-19 COVID-19 infection cytokine cytokine signaling Cytokines decrease donors drug dsRNA dual Effect ELISA epithelial epithelial cells epithelium Ex vivo examined exhibit expression feasibility HBEC HBECs healthy highlight Human IFN signaling IFN-β IL-1β IL-33 IL-6 IL-8 imiquimod IMPROVE infections involved mechanism mRNA multiplex objective pathway poly(I:C poly(I:C) pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines producing protective effect proteomic qPCR Receptor binding reduced reducing resistance mechanisms response Result RT-qPCR SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Severe COVID-19 Infection SP1 spike-protein stimulated subjects suppression target TLR7 TLR7 agonist Tolerance treat Treatment Trigger triggers Viral viral infection viral infections Viral resistance western blot [DOI] 10.3389/fimmu.2021.743890 PMC 바로가기 [Article Type] Immunology
Targeting Inflammasome Activation in COVID-19: Delivery of RNA Interference-Based Therapeutic MoleculesReview Published on 2021-12-032022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] absence Activation approach clinical outcomes clinical trial complications Consequences COVID-19 COVID-19 patient COVID-19 patients Critical delivery dependent on Drug efficacy dysregulation effective Efficacy immune dysregulation Inflammasome inflammasome activation mechanisms microRNA modulating Molecular targets molecule morbidity NLRP3 NLRP3 inflammasome non-coding RNA Non-coding RNAs Numerous pathogenesis of COVID-19 potential therapeutic target pro-inflammatory cytokine pro-inflammatory mediator reduce Research RNA RNA interference RNAs significantly targeting the cytokine storm therapeutic agent Therapeutic molecule Treatment Treatment strategies Vaccines variants of SARS-CoV-2 vector with COVID-19 worsened [DOI] 10.3390/biomedicines9121823 PMC 바로가기 [Article Type] Review