SARS-CoV-2 challenge studies: ethics and risk minimisationCurrent Controversy Published on 2021-12-252022-10-30 Journal: Journal of medical ethics [Category] COVID-19, [키워드] accelerate approach assessment cause clinical implication clinical trials COVID-19 COVID-19 incidence criteria Critical develop effective effective vaccine epidemiological Ethics evaluate exceptional global public health healthy volunteer human infection infecting pathway raised Recognition Research Research Ethics risk SARS-CoV-2 scientific research Treatment virus [DOI] 10.1136/medethics-2020-106504 PMC 바로가기 [Article Type] Current Controversy
The Spread of COVID-19 Crisis Communication by German Public Authorities and Experts on Twitter: Quantitative Content Analysis트위터에서 독일 공공 기관 및 전문가의 COVID-19 위기 커뮤니케이션 확산: 정량적 콘텐츠 분석Original Paper Published on 2021-12-222022-09-10 Journal: JMIR Public Health and Surveillance [Category] SARS, 치료기술, [키워드] Analysis appear association authorities authority carried communication components Consequences content content analysis Coverage COVID-19 COVID-19 case COVID-19 cases COVID-19 crisis COVID-19 pandemic crisis crisis communication Descriptive analysis Descriptive statistics detect development element evaluate example expert experts Germany health authorities incidence rate increasingly information media Multivariate analysis negative negative binomial regression objective pandemic performed positive Public public health authorities Quantitative reached Recognition reduce Regression representing required responsible Result significantly similarities similarity social media Spread Twitter [DOI] 10.2196/31834 PMC 바로가기 [Article Type] Original Paper
The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λResearch Article Published on 2021-12-222022-10-30 Journal: mSphere [Category] Coronavirus, [키워드] Air-liquid interface airway epithelium ALI-REC Alpha Antiviral basal cells Betacoronavirus CCL2 CCL5 Cell culture cell cultures cells change chemokine chemokines ciliated cells coronavirus Culture CXCL10 CXCL8 Cytokines cytopathic disease Donor driving epithelia epithelial lining evaluated expression expression level Gene Expression goblet cells homeostasis IFN-λ1 IFN-stimulated gene IFN-λ IFN-λ1 IL-1β IL-6 IL-8 in vitro in vivo Including Increased infect Infection innate immune gene innate immune response Innate immunity innate response interleukin-1β investigated modulation molecular mechanism morphologically Necrosis Neonatal neurotropic OAS1 outcome pattern PHEV primary site Proinflammatory cytokine proliferative Recognition replicate replicated respiratory respiratory epithelia respiratory epithelial cell resulting RIG Stat1 tissue TLR TLR3 TLR7 TNF-α tracheal transcription factor Transcriptional upregulation triggered turn upper respiratory tract upregulation virus vomiting [DOI] 10.1128/mSphere.00820-21 PMC 바로가기 [Article Type] Research Article
Anti-Inflammatory Effects of Immunostimulation in Patients with COVID-19 PneumoniaArticle Published on 2021-12-092022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission association Biomarker Blood cell supernatant cellular changes in Characteristics chemokines clinical conditions Control COVID-19 cytokine disease severity Effect gene expression pattern Genetic groups IFN-γ IL-4 immune response immunomodulation immunomodulator immunostimulation in vitro in-hospital mortality Inflammatory Influenza innate response intubation rate investigated molecular Neutrophil-to-lymphocyte ratio NLR not differ outcome outcomes Patient pidotimod plasma plasma concentration Pneumonia RCTs Recognition Respiratory failure SARS-CoV-2 Standard of care Standard-of-care systemic corticosteroid therapy toll like receptor Transcription treated upregulated viral infection Viral pneumonia virus were assessed with COVID-19 [DOI] 10.3390/jcm10245765 PMC 바로가기 [Article Type] Article
E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studiesSARS-CoV-2 RBD의 E484K 돌연변이는 hACE2와의 결합 친화도를 향상시키지만 중화 항체 및 나노바디와의 상호작용을 감소시킵니다. 결합 자유 에너지 계산 연구Article Published on 2021-12-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] addition All-atom molecular dynamics simulation angiotensin Angiotensin-converting enzyme antibody binding binding affinities binding affinity Burial cause caused compensating conformational contribute COVID-19 COVID-19 disease death decrease drug design E484K E484K mutation Effect effective effective vaccine Effective vaccines Effectiveness electrostatic interaction ENhance enzyme group hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen Hydrogen bond hydrogen bonds immune response Impact IMPROVE Infection information Interaction investigated leads molecular molecular dynamics Molecular mechanics molecular mechanism mutant mutate Mutation mutations nanobodies nanobody Neutralizing Neutralizing antibodies neutralizing antibody pandemic polar RBD receptor Receptor binding receptor hACE2 Receptor-binding domain Recognition reduce reduced residue SARS-CoV-2 SARS-CoV-2 RBD selected significantly surface area the binding affinity the receptor-binding domain Transmissibility Vaccine development variant variants [DOI] 10.1016/j.jmgm.2021.108035 PMC 바로가기 [Article Type] Article
Mortality risk factors in a Spanish cohort of oldest-old patients hospitalized with COVID-19 in an acute geriatric unit: the OCTA-COVID study급성 노인병동에 COVID-19로 입원한 스페인 고령 환자 집단의 사망률 위험 요인: OCTA-COVID 연구Observational Study Published on 2021-12-012022-09-11 Journal: European Geriatric Medicine [Category] SARS, 변종, 임상, [키워드] 95% CI Admission age angiotensin angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors Barthel Index Characteristics clinical clinician co-morbidities cognitive Cohort COVID-19 Cox proportional hazard models CURB CURB-65 score delirium Dementia demographics determine during admission electronic medical records evaluate Factor Falls females functional help hospital Hospital admission Hydroxychloroquine in-hospital mortality in-hospital mortality rate index Laboratory morbidities Mortality mortality rate Most patient Most patients observational study Older adults Patient patients patients hospitalized polypharmacy predictor prescription Prognosis Radiographic Recognition retrieved risk factor Risk factors SARS-CoV-2 scale setting Spanish syndrome Treatment unit were used with COVID-19 [DOI] 10.1007/s41999-021-00541-0 PMC 바로가기 [Article Type] Observational Study
Paper-Based Test for Rapid On-Site Screening of SARS-CoV-2 in Clinical Samples임상 샘플에서 SARS-COV-2의 빠른 현장 스크리닝을위한 종이 기반 테스트Article Published on 2021-11-302022-09-01 Journal: Biosensors [Category] 진단, 치료기술, [키워드] amplification buffer capture clinical clinical samples colorimetric detection Concentration COVID-19 pandemic detect detection Efficiency focus horseradish peroxidase HRP lateral flow lateral flow assay lateral flow strip magnetic focus enhancement nasal swab pathogen Pathogens PBS peroxidase probe Rapid Recognition recognize Saliva saliva samples Sample SARS-CoV-2 SARS-CoV-2 monitoring Screening sensitivity specificity Spread Test the SARS-CoV-2 virus particles was used [DOI] 10.3390/bios11120488 PMC 바로가기 [Article Type] Article
Using intervention mapping to develop ‘ROSE’: an intervention to support peer workers in overdose response settingsResearch Article Published on 2021-11-272022-10-28 Journal: BMC health services research [Category] Coronavirus, MERS, SARS, [키워드] analyzed baseline can be used change characterized Community conducted COVID-19 pandemic Critical deaths develop emotional facilitate group identify impacts Intervention intervention mapping lived/living experience mapping Mental organization organizations outlined overdose response peer Peer workers positive public health Recognition Result skill Stigma Substance use supplementary material Support transcript turn working [DOI] 10.1186/s12913-021-07241-2 PMC 바로가기 [Article Type] Research Article
Antibodies specific to SARS-CoV-2 proteins N, S and E in COVID-19 patients in the normal population and in historical samples정상 인구 및 과거 샘플의 COVID-19 환자에서 SARS-CoV-2 단백질 N, S 및 E에 특이적인 항체Animal Published on 2021-11-242022-09-10 Journal: The Journal of General Virology [Category] MERS, SARS, 진단, 치료법, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus analysed antibodies antibody Antibody Response can not circulation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient diagnostic domain envelope protein epidemiological healthy IgA IgA levels IgG IgG level immune response immune responses immunology Infection inhibit SARS-CoV-2 Kinetics nucleocapsid protein other coronavirus other coronaviruses pandemic Patient preserved Protective protective role Recognition respiratory SARS-CoV-2 SARS-CoV-2 protein sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Spread target the SARS-CoV-2 Treatment virus virus-neutralizing [DOI] 10.1099/jgv.0.001692 PMC 바로가기 [Article Type] Animal
Real-Time Infoveillance of Moroccan Social Media Users’ Sentiments towards the COVID-19 Pandemic and Its ManagementArticle Published on 2021-11-192022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Analysis classical collected data COVID-19 COVID-19 mitigation dataset Dialect dominant Effects emotion Emotion analysis emotional events expressed Facebook Government identify Interaction language machine learning management media Model modeling Modern Standard Arabic Morocco outperform pandemic platform polar sentiment analysis protocol public health reaction Recognition Regulation respond significantly social distancing Topic topic modeling Universal universal language model for Moroccan dialect website [DOI] 10.3390/ijerph182212172 PMC 바로가기 [Article Type] Article