Gene Presence/Absence Variation analysis of coronavirus family displays its pan-genomic diversityResearch Paper Published on 2021-08-272022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, [키워드] Analysis conserved core gene coronavirus COVID-19 diagnostic reagent Diversity feature Genes Genome genomic IMPROVE M gene N gene nucleic acid Pangenomics RNA viruses S gene SARS-CoV-2 target the SARS-CoV-2 viral genome whole genome [DOI] 10.7150/ijbs.58220 PMC 바로가기 [Article Type] Research Paper
SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective ImmunityS1/S2 절단 부위에서 돌연변이를 갖는 SARS-CoV-2는 약화된 독성을 나타내고 보호 면역을 부여합니다Research Article Published on 2021-08-242022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] activate affecting airway animal model attenuation B.1.1.7 Bearing body weight Body weight loss cause cell tropism cellular entry cleavage cross-react exhibited furin furin cleavage site furin protease growth hamster hamsters Host immunogens infected with SARS-CoV-2 Infection Inflammatory response inoculated investigated Lineage lineages Mild motif mutant mutants Mutation Neutralizing antibodies P.1 parental Pathogenesis pathogenic pathway polybasic potential benefit potential benefits protective neutralizing antibodies protective neutralizing antibody proteolytic cleavage respiratory S gene S1/S2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Site spike Spike protein subsequent the spike protein tissue variant Viral viral growth weight loss [DOI] 10.1128/mBio.01415-21 PMC 바로가기 [Article Type] Research Article
High throughput diagnostics and dynamic risk assessment of SARS-CoV-2 variants of concern우려되는 SARS-CoV-2 변종에 대한 높은 처리량 진단 및 동적 위험 평가Research Paper Published on 2021-08-122022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] appearance B.1.1.7 coupling demonstrated diagnostics Early detection eight England Epidemiological investigation epidemiological surveillance finding genomic region mapped Mass testing molecular network new SARS-CoV-2 Next-generation sequencing nose and throat occurred ORF1ab pandemic park PCR positive positive PCR positive sample public health Real-time tracking respiratory risk S gene SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant Sequencing Spread Support Surveillance swab sample tested Transmission variant VoC VOC 202012/01 VOC-202012/01,B.1.1.7 was used whole-genome sequencing [DOI] 10.1016/j.ebiom.2021.103540 PMC 바로가기 [Article Type] Research Paper
Novel SARS-CoV-2 variants: the pandemics within the pandemic새로운 SARS-CoV-2 변종: 대유행 내의 대유행Review Published on 2021-08-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 변종, 진단, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation Affect affinity antibody Antibody binding approach article assays B.1.1.7 B.1.351 binding bioRxiv Brazil cell receptor coronavirus COVID-19 decrease described diagnostic E484K E484K mutation Efficacy expected Frequency globe greater Grey literature herd immunity Human humans immune Immune escape Immunity in vitro increase initial knowledge multiplex Mutation mutations N501Y mutation Neutralizing antibodies novel P.1 P.1 variant pandemic Pandemics phenotypical Re-infection reduced respiratory risk S gene SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened searched sequence Sequencing severe acute respiratory syndrome Coronavirus severity South Africa Spike protein Surveillance the SARS-CoV-2 the spike protein therapy Transmissibility Transmission Treatment treatment failure United Kingdom vaccination Vaccine Vaccines variant variant of concern variants virus VoC while Wuhan [DOI] 10.1016/j.cmi.2021.05.022 PMC 바로가기 [Article Type] Review
Molecular Biology and Pathological Process of an Infectious Bronchitis Virus with Enteric Tropism in Commercial BroilersArticle Published on 2021-07-282022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition Biology Broiler bronchitis caused controls demonstrated determine disease Embryo enteric enteric tropism gastrointestinal tract Genome Health IBV identity IHC induce Infectious bronchitis intestinal intestines lesion M41 molecular mechanism nucleotide Pathogenesis pathological Phylogenetic analysis Process replicate reported runting-stunting syndrome S gene salmonellosis similarity SPF staining Strains syndrome tissue tropism tropism unique vaccination variant variants viral shedding virus whole-genome whole-genome sequencing [DOI] 10.3390/v13081477 PMC 바로가기 [Article Type] Article
Emergence and Spread of B.1.1.7 Lineage in Primary Care and Clinical Impact in the Morbi-Mortality among Hospitalized Patients in Madrid, SpainArticle Published on 2021-07-152022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Admission Alpha variant B.1.1.7 B.1.1.7 lineage B1.1.7 lineage Burden of disease characterized clinical death rate declining deletions detect disease dominant emergence healthcare Impact increase in intensive care Mutation new SARS-CoV-2 no difference pandemic Patient patients treated positive result prevalent primary care Probability reached replacement respiratory sample S gene SARS-CoV-2 SARS-CoV-2 variant screened Spain Spread spread to the spike protein variant variants [DOI] 10.3390/microorganisms9071517 PMC 바로가기 [Article Type] Article
Specific allelic discrimination of N501Y and other SARS‐CoV‐2 mutations by ddPCR detects B.1.1.7 lineage in Washington StateResearch Article Published on 2021-07-032022-11-01 Journal: Journal of medical virology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome allele allelic Alpha Amino acid B.1.1.7 B.1.1.7 lineage B.1.1.7 variant can be used Clustering Combination contagious coronavirus COVID‐19 COVID‐19 ddPCR detect diagnostic epidemiological form GCA Genetic help identify increasingly limit Lineage molecular multiplex Mutation N501Y N501Y mutation offer Phylogenetic polymerase chain positive prevalent required RT‐PCR S gene S982A SARS‐CoV‐2 SARS‐CoV‐2 screened Sequencing SGTF Specific Spread state target TAT Thermofisher Transmissibility variants variants of concern virulence VoC VOCs Washington [DOI] 10.1002/jmv.27155 PMC 바로가기 [Article Type] Research Article
Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations우성 돌연변이가 있거나 없는 SARS-CoV-2 게놈 간의 S 및 RdRp의 다른 선택 역학Article Published on 2021-07-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, [키워드] affected appearance Betacoronavirus cells coding region content correlated COVID-19 COVID-19 pandemic Critical dominant fitness genomic Genotype genotypes glycoprotein highest infectiousness isolate isolates mutant Mutation mutation rate Mutation rates mutations pandemic peptide pharmaceutical Positive selection Protein RdRP Replication Research responsible RNA RNA polymerase RNA-dependent RNA polymerase S gene S protein SARS-CoV-2 SARS-CoV-2 genes SARS-CoV-2 genome SARS-COV-2 infection sequence shown surface Surface glycoprotein the S protein the SARS-CoV-2 genome Tolerance viral entry viral genome virus [DOI] 10.1016/j.meegid.2021.104796 PMC 바로가기 [Article Type] Article
Genetic characterization and phylogenetic analysis of porcine epidemic diarrhea virus in Guangdong, China, between 2018 and 2019Research Article Published on 2021-06-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] acute diarrhea amino acid insertion Characteristics China circulating clinical collected coronavirus diarrhea dominant eight epidemic diarrhea full-length S gastroenteritis gene sequence Genetic glycosylation site Guangdong incidence information observation occurred Outbreaks Pathogens PEDV Phylogenetic analysis Porcine deltacoronavirus producing recombination event Region S gene strain Strains suggested syndrome tested TGEV the epidemic Vaccine vaccine strain variant virus [DOI] 10.1371/journal.pone.0253622 PMC 바로가기 [Article Type] Research Article
Multiple detection and spread of novel strains of the SARS-CoV-2 B.1.177 (B.1.177.75) lineage that test negative by a commercially available nucleocapsid gene real-time RT-PCR시판되는 뉴클레오캡시드 유전자 실시간 RT-PCR로 음성 판정을 받은 SARS-CoV-2 B.1.177(B.1.177.75) 계통의 신규 균주 다중 검출 및 확산Original Article Published on 2021-06-132022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 치료기술, 치료법, [키워드] Abruzzo activity adopted Analysis B.1.177 circulating Cluster Clusters connection COVID-19 Diagnosis diagnostic epidemiological Epidemiology Genetic genomic data highlight independent involved Italy knowledge Lineage majority Molecular tests Multiple Mutation mutations N gene nucleocapsid Nucleocapsid gene nucleotide nucleotide sequence occur ORF1 ORF1ab performed Phylogeny polymerase chain reaction positive primer Primers probe real-time RT-PCR RT-PCR S gene SARS-CoV-2 sequence sequences Sequencing Spread strain Strains Support synonymous TaqPath test negative tested the SARS-CoV-2 Thermofisher turn unique [DOI] 10.1080/22221751.2021.1933609 PMC 바로가기 [Article Type] Original Article