Comparison of Rapid and Automated Antigen Detection Tests for the Diagnosis of SARS-CoV-2 InfectionArticle Published on 2022-01-042022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Antigen antigen detection antigen testing automated automated assay comparable Concentration COVID-19 detection diagnosis of SARS-CoV-2 diagnostic France Infection intensity investigated less manual assay nasopharyngeal sample Nasopharyngeal swab nucleocapsid Paris performance Quantitative Rapid RAT RT-PCR RT-PCR assay RT-PCR Ct SARS-CoV-2 SARS-CoV-2 viral sensitivity Test tested university variants variants of SARS-CoV-2 was determined [DOI] 10.3390/diagnostics12010104 PMC 바로가기 [Article Type] Article
Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of GabonB.1.1.318 SARS-CoV-2 바이러스 계통의 출현 및 가봉 공화국에서 우려되는 알파 B.1.1.7 변이체의 높은 발생률Article Published on 2022-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 치료기술, [키워드] addition Alpha Alpha VOC Analysis B.1.1.318 B.1.1.7 B.1.1.7 variant Central Africa distribution Efficacy emergence Gabon Genome genomes Guidance highlight imperative implication incidence Lineage lineages MinION Nanopore Oxford Oxford Nanopore Phylogenetic analysis SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 viral second wave sequenced study period Surveillance the SARS-CoV-2 genome Transmissibility Transmission Vaccine vaccine efficacy variant variant of concern variants VoC VOCs was performed [DOI] 10.1016/j.ijid.2021.10.057 PMC 바로가기 [Article Type] Article
Performance of a high-throughput, automated enzyme immunoassay for the detection of SARS-CoV-2 antigen, including in viral “variants of concern”: Implications for clinical use바이러스 "관심 있는 변이체"를 포함하여 SARS-CoV-2 항원 검출을 위한 고처리량 자동화 효소 면역분석의 성능: 임상 사용에 대한 시사점Article Published on 2022-01-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 변종, 치료기술, [키워드] alternative Antigen antigen test automated Clinical use Cohort cohorts of patients collected complement diagnostic Direct EIA enzyme enzyme immunoassay Epidemic epidemiological evaluated French immunoassay in viral Laboratory NPs NPSs nucleic acid nucleic acid testing Patient performance positive provided reported retrospective cohort RT-PCR SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 RNA SARS-CoV-2 viral second wave sensitivities sensitivity specificity subject subjects Support tested thresholds variant variants variants of concern viral antigens [DOI] 10.1016/j.jcv.2021.105048 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection among hospitalised pregnant women and impact of different viral strains on COVID-19 severity in Italy: a national prospective population-based cohort study입원한 임산부의 SARS-CoV-2 감염과 이탈리아의 COVID-19 심각도에 대한 다양한 바이러스 균주의 영향: 국가 전향적 인구 기반 코호트 연구Article Published on 2022-01-012022-09-11 Journal: BJOG : an international journal of obstetrics and [Category] SARS, 변종, [키워드] 95% CI Admission age Asymptomatic Birth rate citizenship clinician Cohort Cohort studies Comorbidity country COVID-19 COVID-19 disease COVID-19 illness COVID-19 pneumonia COVID-19 severity death described Hospital admission hospitalised hospitals ICU ICU admission intensive care intensive care unit Italian Italy Maternal maternal age Migration mode multivariate analyses National Neonatal Neonatal Mortality obesity Occurrence outcome outcomes Pneumonia population-based cohort Pregnancy pregnant women Preterm birth prospective cohort study remained reported required Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral severe COVID-19 disease severe COVID-19 illness severity significant increase Stillbirth strain ventilatory support viral strain virus variant virus variants wild-type women [DOI] 10.1111/1471-0528.16980 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energeticsArticle Published on 2022-01-012022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract Alter ATP synthase autophagy cardiovascular cardiovascular medicine cause Cell cell death cellular cellular damage complex component conducted coronavirus coronavirus disease COVID-19 Cycling cyclosporin cyclosporin A Disease progression disrupt domain Endoplasmic reticulum ENhance exacerbate lack mitochondrial Mitochondrial function molecular basis NSP6 ORF10 organelle PBMCs promote Protein Quality control quality-control Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 viral significant changes in suppress suppressed transcript transcriptomic analysis transcriptomics Treatment viability Virology [DOI] 10.1016/j.isci.2021.103722 PMC 바로가기 [Article Type] Article
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations신장 오르가노이드 및 임상 인구에서 SARS-CoV-2 반응의 교차 검증Research Article Published on 2021-12-222022-09-10 Journal: JCI Insight [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Alpha ameliorated Apoptosis Beta blocked Cell cell types Clinical data comparable COVID-19 Critical Critically ill Critically ill patient critically ill patients Cross-validation feature gene expression pattern gene expression patterns Genetic diseases infect Infection interferon interferon pathway iPS cells Kidney disease kidney infection kidney organoid kidneys mechanism Molecular pathology morphology Nephrology organ Organoid organoids peptides polycystic kidney polycystic kidney disease Population populations proteomic proximal proximal tubules reflect reflected replicating virus response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral susceptibility target organs Therapeutics Therapies Treatment tropism upregulation Urine variant Viral viral fitness [DOI] 10.1172/jci.insight.154882 PMC 바로가기 [Article Type] Research Article
A comparison of four commercially available RNA extraction kits for wastewater surveillance of SARS-CoV-2 in a college population대학 인구에서 SARS-CoV-2의 폐수 감시를 위한 4개의 상업적으로 이용 가능한 RNA 추출 키트의 비교Article Published on 2021-12-202022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] analyzed applicability collected Community comparable Concentration cumulative effective England Epidemiology evaluated extraction homogenization include inhibitor Isolation Localized methodology Monarch nasopharyngeal swabs New Outbreaks pellet plasmid standard positive PrEP Prevalence primer processed public health Public health interventions Qiagen quantified reaction Research RNA RNA extraction kit RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection SARS-CoV-2 viral sewage Surveillance tested Viral RNA virus wastewater Wastewater-based epidemiology water WBE, sewage, COVID-19 while Zymo [DOI] 10.1016/j.scitotenv.2021.149595 PMC 바로가기 [Article Type] Article
COVID-19 wastewater surveillance in rural communities: Comparison of lagoon and pumping station samples농촌 지역 사회의 COVID-19 폐수 감시: 석호 및 펌프장 샘플 비교Article Published on 2021-12-202022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, 치료제, [키워드] applied Biomarkers Canada Chain Reaction changes in collected Community country COVID-19 downstream Epidemiology fecal granularity implementation incidence incidence of COVID-19 integrity knowledge lagoon limit Mild N1 and N2 pathogen Pathogens Pepper mild mottle virus polymerase chain polymerase chain reaction Prevalence prevalence of COVID-19 pumping station quantification Quantitative Region RNA concentration RNA concentrations RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 surveillance SARS-CoV-2 viral stability Surveillance Topic Treatment upstream viral signal wastewater wastewater surveillance Wastewater treatment lagoon Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.149618 PMC 바로가기 [Article Type] Article
The pigtail macaque ( Macaca nemestrina ) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of diseaseCOVID-19의 돼지꼬리원숭이(Macaca nemestrina) 모델은 다양한 임상 결과를 재현하고 질병의 새롭고 복잡한 징후를 나타냅니다.Research Article Published on 2021-12-202022-09-10 Journal: PLoS Pathogens [Category] 변종, 진단, [키워드] animal animal model animal models approach Blood Cardiovascular Symptoms causative agent CD4+ CD4+ T cell CD4+ T cells CD8 claimed Clinical outcome Coagulation Cohort complex COVID-19 COVID-19 disease COVID-19 pandemic Critical disease drug Effective vaccines euthanized exhibited Express feature FIVE human disease humans immune Increases increases in Infection infection with SARS-CoV-2 Inflammatory lesions less macaque manifestation marker mechanism Mild-to-moderate Neutralizing antibodies Novel coronavirus novel coronavirus SARS-CoV-2 Pathogenesis pathologic Pigtail pulmonary pulmonary infiltrates respiratory respiratory viral reveal rising SARS-COV-2 infection SARS-CoV-2 viral severe COVID-19 disease severe disease severe disease course simian immunodeficiency virus SIV span Symptom T cell T cells tested Therapeutics transmissible variant transmissible variants treat Vaccine Viral viral dynamics viruses with infections [DOI] 10.1371/journal.ppat.1010162 PMC 바로가기 [Article Type] Research Article
Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia몽골의 4가지 SARS-CoV-2 백신에 대한 항체 반응의 직접 비교Observational Study Published on 2021-12-082022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] Alpha Alpha variant antibody Antibody Response Antibody responses Antibody testing Antibody titer Antibody titers approved AstraZeneca blocking activity caused collected comparison COVID-19 Direct individual Infection Mongolia Mongolian nine participant Pfizer Pfizer/BioNTech plasma Protein Public health intervention Public health interventions RBD RBD-ACE2 Receptor binding domain reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 viral serology Sinopharm specimen Sputnik V stimulate stimulated the antibody response These data vaccination Vaccine vaccine responses Vaccines variant Viral Viral variants [DOI] 10.1016/j.chom.2021.11.004 PMC 바로가기 [Article Type] Observational Study