Neutralizing Antibody Response to Pseudotype Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Differs Between mRNA-1273 and BNT162b2 Coronavirus Disease 2019 (COVID-19) Vaccines and by History of SARS-CoV-2 Infection유사형 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 중화 항체 반응은 mRNA-1273과 BNT162b2 코로나바이러스 질병 2019(COVID-19) 백신과 SARS-CoV-2 감염의 역사에 따라 다릅니다.Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] 19 2 95% confidence interval Antibody titer BNT162b2 BNT162b2 vaccine calculated coronavirus 2 CoV COVID COVID-19 Dilution dose geometric mean GMT GMTs highest history increase Infection inhibitory linear mixed-effects models mRNA mRNA COVID-19 vaccine mRNA vaccine mRNA-1273 mRNA-1273 vaccine NAb Neutralizing antibodies neutralizing antibody participant participants with SARS-CoV-2 prospective cohort pseudotype virus receiving respiratory response SARS SARS-CoV-2 SARS-COV-2 infection sera single dose Symptoms T Test tested uninfected participant uninfected participants vaccination Vaccine vaccine dose was collected [DOI] 10.1093/cid/ciab1038 PMC 바로가기 [Article Type] Article
The Effect of Gestational Age at BNT162b2 mRNA Vaccination on Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody LevelsBNT162b2 mRNA 백신 접종 시 재태 연령이 산모 및 신생아 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 항체 수준에 미치는 영향Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] acute respiratory syndrome age Antenatal anti-S antibody antibody level antibody transfer antibody waning benefit Blood BNT162b2 mRNA booster dose Care collected coronavirus coronavirus 2 Coronavirus disease 2019 COVID-19 early gestation Effect evaluated Evaluating highest IgG level immunization implication infancy Level lowest Maternal mRNA vaccination Neonatal parturient Pregnancy Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 BNT162b2 SARS-CoV-2 spike protein sera serology severe disease significantly higher vaccination Vaccination strategies Vaccine vaccine dose [DOI] 10.1093/cid/ciac135 PMC 바로가기 [Article Type] Article
Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine RecipientsBNT162b2 또는 CoronaVac 백신 수혜자의 혈청에 의한 중증 급성 호흡기 증후군 코로나바이러스 2 오미크론 변이체의 중화Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titer Antibody titers Beta Beta variant beta variants BNT162b2 CoronaVac coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Delta variants detectable Effectiveness elicited evade genome sequence geometric geometric mean GISAID database GMT GMTs Health Organization isolate Lineage Live virus microneutralization Mutation Nanopore nanopore sequencing neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer no significant difference not affect of BNT162b2 omicron Omicron variant Patient recipient recipients respiratory risk Risk assessment SARS-CoV-2 Sequencing sera severe acute respiratory syndrome Coronavirus significant difference significantly lower spike mutation strain Strains susceptibility TMPRSS2 Vaccine Vaccines variant variant of concern VeroE6 cells virus was determined whole genome sequence World Health Organization [DOI] 10.1093/cid/ciab1041 PMC 바로가기 [Article Type] Article
Squalene in oil-based adjuvant improves the immunogenicity of SARS-CoV-2 RBD and confirms safety in animal models오일 기반 보조제의 스쿠알렌은 SARS-CoV-2 RBD의 면역원성을 개선하고 동물 모델에서 안전성을 확인합니다Article Published on 2022-08-232022-09-11 Journal: PLoS ONE [Category] SARS, 변종, 진단, 치료기술, [키워드] accelerated adjuvant Analysis animal model assays binding Cellular immune response Chromatography conditions COVID-19 demonstrated determine determined by elicited ELISA etiologic agent evaluated expressed flow cytometry Formulation hamsters histopathological humoral immune immunization immunogenicity IMPROVE insect cell insect cells kidney lead liver Lungs mice Neutralizing antibodies neutralizing antibody pandemic Protein purified RBD of SARS-CoV-2 RBD protein receptor Safe SARS-CoV-2 SARS-CoV-2 RBD sera shown squalene stimulate sub-unit vaccine the Spike Vaccine vaccine candidate variant virus water [DOI] 10.1371/journal.pone.0269823 PMC 바로가기 [Article Type] Article
SARS-CoV-2-reactive IFN-γ-producing CD4 + and CD8 + T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients혈액 내 SARS-CoV-2 반응성 IFN-γ 생성 CD4 + 및 CD8 + T 세포는 백신 접종을 받지 않은 중환자 COVID-19 환자의 임상 중증도와 상관관계가 없습니다Article Published on 2022-08-222022-09-11 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] anti-RBD Anti-RBD IgG association Biomarker Biomarkers Blood blood levels C-reactive protein CD4 CD8 Clinical outcome Clinical severity comparable Concentration correlation COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients D-dimer Deceased detectable died different time point different time points ELISA Enumeration enzyme enzyme-linked immunosorbent assay examined ferritin flow cytometry greater magnitude IFN-γ IgG level increased mortality interleukin interleukin-6 investigated Kinetics Lactose Lower respiratory tract male median age membrane protein Mortality no correlation Patient patients Peripheral blood predict respiratory RNA loads SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 S sera Serum level serum levels specimens spike Spike protein survived Survivors T cell T cell subset T cells T-cell T-cell Response T-cell responses tracheal aspirate Viral viral clearance [DOI] 10.1038/s41598-022-18659-x PMC 바로가기 [Article Type] Article
A highly efficacious live attenuated mumps virus-based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike6-프롤린 안정화된 융합전 스파이크를 발현하는 매우 효과적인 약독화성 볼거리 바이러스 기반 SARS-CoV-2 백신 후보Article Published on 2022-08-162022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody backbone candidate children COVID-19 vaccine Delta delta variant Delta variants effective expressed expressing expression Genome hamster human vaccine IFNAR1 immune responses Immunity immunization immunogenic Immunoglobulin immunoglobulin A include Infant Infants intranasal junction mice MMR MMR vaccine mucosal mump mumps virus neutralized Neutralizing antibodies neutralizing antibody prefusion proline prolines raised rapid increase Safe SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein T cell tetravalent Vaccine vaccine strain variants virus [DOI] 10.1073/pnas.2201616119 PMC 바로가기 [Article Type] Article
Antibodies against the SARS-CoV-2 S1-RBD cross-react with dengue virus and hinder dengue pathogenesisArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute respiratory syndrome addition anti-SARS-CoV-2 antibody Antibody-dependent enhancement antigenic bleeding controls coronavirus COVID-19 COVID-19 patient cross-protection cross-react cross-reactive antibody cross-reactivity dengue patient dengue virus Diagnosis disease disease severity domain endothelial envelope protein epitope False-positive hyperimmune IgG in vitro induce Infection inhibited mice Neutralizing nonstructural protein 1 passive transfer Pathogenesis peptide promote purified random reaction reduced reported SARS-CoV-2 SARS-COV-2 infection sera serology test significantly increased Spike protein Spread the SARS-CoV-2 [DOI] 10.3389/fimmu.2022.941923 PMC 바로가기
Combining Deep Phenotyping of Serum Proteomics and Clinical Data via Machine Learning for COVID-19 Biomarker DiscoveryCOVID-19 바이오마커 발견을 위한 기계 학습을 통한 혈청 단백질체학 및 임상 데이터의 심층 표현형 결합Article Published on 2022-08-152022-09-11 Journal: International Journal of Molecular Sciences [Category] 바이오마커, 유전자 메커니즘, [키워드] analyzed Biomarker Biomarkers cardiometabolic CD200R1 Central nervous system clinical Clinical practice contributed COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient dataset deep disease disease severity Diseases downregulated enrolled Factors IL6 IMPROVE Inflammation KIT LTBP2 lymphocyte lymphocyte counts machine learning MATN3 MCP1 MOST MRAP natural history neurologic neurologic disease neutrophil nine outcome pathology persistence Phenotyping Protective Protein proximity extension assay sera serological data serum biomarker serum biomarkers severe cases small sample size statistical TRANCE unique variable [DOI] 10.3390/ijms23169161 PMC 바로가기 [Article Type] Article
Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineagesSARS-CoV-2 Omicron BA.1, BA.1.1, BA.2 및 BA.3 하위 계통의 항체 회피Article Published on 2022-08-102022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody Antibody therapeutics antigenic approved BA.1 BA.1.1 BA.2 BA.3 BBIBP-CorV booster comparison dominant dose Efficacy highlighting homologous or heterologous IMPROVE inactivated individual lineages mAb mAbs monoclonal antibody MOST neutralization neutralization activity neutralization titer neutralization titers Neutralizing activity omicron profile pseudovirus reported SARS-CoV-2 sera side spike mutations Vaccine variant [DOI] 10.1016/j.chom.2022.05.001 PMC 바로가기 [Article Type] Article
Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2SARS-CoV-2 Omicron 하위 계통 BA.1, BA.1.1 및 BA.2의 중화Article Published on 2022-08-102022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] BA.1 BA.1.1 BA.2 booster doses Booster vaccine COVID-19 COVID-19 patient dose highlight Immune escape Immunity individuals lineages mRNA mRNA vaccine natural infection neutralization neutralized Neutralizing antibodies neutralizing antibody omicron overcome patient sera patients recent Recovered COVID-19 patients SARS-CoV-2 sensitivity sera Vaccine variant while [DOI] 10.1016/j.chom.2022.04.014 PMC 바로가기 [Article Type] Article