Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass SpectrometryArticle Published on 2021-03-162022-10-29 Journal: SLAS discovery : advancing life sciences R & D [Category] COVID-19, SARS, [키워드] activity acute respiratory syndrome Analysis Antiviral conserved coronavirus Coronavirus-2 Coronaviruses COVID-19 COVID-19 infection develop development drug drugs Efficiency enzyme evade exonuclease food Formation Health help Host in viral inhibitor mass methyltransferase nsp14 Outbreaks Protein Replication responsible SARS-CoV SARS-CoV-2 Screening selective shown similarity specific treatment Spectrometry starting point the SARS-CoV-2 therapy translation viral genome Viral RNA [DOI] 10.1177/24725552211000652 PMC 바로가기 [Article Type] Article
Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysisResearch Article Published on 2021-03-122022-10-27 Journal: BMC Biotechnology [Category] COVID-19, [키워드] Analysis applicability approach biological processe candidate drug candidate drugs Cluster collected complexes Coronavirus disease-19 costly COVID-19 COVID-19 pandemic database disease drug Drug discovery drug target drugs targeting effective drug experimental analysis experimental validation gene target Human identify Interaction investigated involved miRNA miRNAs network analysis PPI PPI network Protein protein-protein interaction Proteins provide reconstructed Regulation reported repurposing required researcher Result SARS-CoV-2 Seven Spread starting point supplementary material the SARS-CoV-2 virus therapeutic therapeutic purposes therapy therapy for COVID-19 time-consuming Toxicity treat Treatment urgency was obtained Wuhan, China [DOI] 10.1186/s12896-021-00680-z PMC 바로가기 [Article Type] Research Article
Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysisResearch Article Published on 2021-03-122022-10-27 Journal: BMC Biotechnology [Category] Coronavirus, COVID-19, SARS, [키워드] Analysis applicability approach biological processe candidate drug candidate drugs Cluster collected complexes Coronavirus disease-19 costly COVID-19 COVID-19 pandemic database disease drug Drug discovery drug target drugs targeting effective drug experimental analysis experimental validation gene target Human identify Interaction investigated involved miRNA miRNAs network analysis PPI PPI network Protein protein-protein interaction Proteins provide reconstructed Regulation reported repurposing required researcher Result SARS-CoV-2 Seven Spread starting point supplementary material the SARS-CoV-2 virus therapeutic therapeutic purposes therapy therapy for COVID-19 time-consuming Toxicity treat Treatment urgency was obtained Wuhan, China [DOI] 10.1186/s12896-021-00680-z PMC 바로가기 [Article Type] Research Article
Predicting fear and perceived health during the COVID-19 pandemic using machine learning: A cross-national longitudinal studyResearch Article Published on 2021-03-112022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] addition age Analysis Anxiety contribute country COVID-19 pandemic Critical Czech Republic disease effect sizes effective environmental factor environmental factors Factor Factors Features Health influence introduced lockdown restriction Mortality offer over Pandemics participant pathogen physical Poland predict predicted Predictive predictor predictors Protective Psychological Research response Result Spain Spread starting point trajectory unique variable virus [DOI] 10.1371/journal.pone.0247997 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Main Protease Active Site Ligands in the Human MetabolomeArticle Published on 2021-03-052022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] 3C-like protease 3CL Protease acute respiratory syndrome Analysis antioxidant antiviral activities antiviral therapies binding biochemical coronavirus COVID-19 global pandemic Human human metabolome in silico inhibit lifecycle M pro MPro metabolome occurred protease protease inhibitors representing Research SARS-CoV-2 shown silybin Silybum silymarin Site starting point the Coronaviridae the SARS-CoV-2 therapeutic strategy virus [DOI] 10.3390/molecules26051409 PMC 바로가기 [Article Type] Article
Impact of Ethnicity on COVID-19 Related Hospitalizations in Children During the First Pandemic Wave in Northern ItalyPediatrics Published on 2021-02-042022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Affect African age Asymptomatic disease Care cause children collected data Comorbidities COVID-19 Deceased Ethnicity Europe Evidence FIVE Health higher risk highest hospital Hospitalization Hospitalized Impact incidence Infant information Italian Italy less Mild no significant difference Odds ratio overcome pandemic pediatric Population risk SARS-CoV-2 severe COVID-19 disease Sex significantly higher starting point the patient Wave [DOI] 10.3389/fped.2021.625398 PMC 바로가기 [Article Type] Pediatrics
Analysis of the scientific production of the effect of COVID-19 on the environment: A bibliometric studyResearch article Published on 2021-02-012022-10-05 Journal: Environmental research [Category] SARS, 유전자 메커니즘, [키워드] Analysis article bibliometric analysis communication coronavirus COVID-19 Environmental studies evaluate evaluate the effect global pandemic growth help Journalism knowledge Mass media mitigate offer pandemic Perspective positive Radiation reduction in Research Scientific community SciMAT starting point subject ultraviolet Web of Science [DOI] 10.1016/j.envres.2020.110416 [Article Type] Research article
Examining Australian public perceptions and behaviors towards a future COVID-19 vaccineResearch Article Published on 2021-01-282022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, [키워드] acceptance agreement Analysis Attitudes chronic disease communication Community COVID-19 COVID-19 vaccine cross-sectional demonstrated effective Examining Government Health identify immunisation Infection male multivariable logistic regression National occur Older pandemic positive PROTECT respondent Result starting point statistical analysis Support supported vaccinate vaccination Vaccination decisions Vaccine Vaccines [DOI] 10.1186/s12879-021-05833-1 PMC 바로가기 [Article Type] Research Article
The dual effect of social ties on COVID-19 spread in JapanArticle Published on 2021-01-152022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] age aggregate Analysis Care Case fatality rate Community confirmed case controlling COVID-19 COVID-19 case current spread disaster Facebook Gender Government Health health care systems help impacts indicate Infectious diseases Japan lack Local mitigate Natural hazards outcome Resilience Respiratory tract diseases Risk factors Spread starting point the disease [DOI] 10.1038/s41598-021-81001-4 PMC 바로가기 [Article Type] Article
Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential DrugArticle Published on 2021-01-132022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 3C-like protease 3CL Protease acid Analysis antiviral drug Clinical use coronavirus COVID-19 drug Drug repurposing effective effective inhibitor effort Epidemic global pandemic inhibitor main protease morbidity and mortality MPro occurred outbreak Potential protease protease inhibitors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease Spread starting point the Coronaviridae the SARS-CoV-2 therapeutic strategy These data treat Vaccine development virus [DOI] 10.3390/v13010106 PMC 바로가기 [Article Type] Article