the N protein – Page 8 – Communicable Diseases Research

A review of the genome, epidemiology, clinical features, prevention, and treatment scenario of COVID-19: Bangladesh aspects

Reviews

Published on 2021-01-292022-10-31
Journal: The Egyptian Journal of Bronchology [Category] COVID-19,

SARS-CoV-2 Epitope Mapping on Microarrays Highlights Strong Immune-Response to N Protein Region

Article

Published on 2021-01-112022-10-28
Journal: Vaccines [Category] COVID-19,

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

COVID-19 임상 스펙트럼 전반에 걸쳐 어린이와 성인에서 SARS-CoV-2에 대한 뚜렷한 항체 반응

Article

Published on 2021-01-012022-09-11
Journal: Nature Immunology [Category] Fulltext, SARS, 임상, 진단, 치료기술, 치료법,

[키워드] acute respiratory distress acute respiratory distress syndrome age Anti-spike antibodies Antibody Response ARDS breadth caused children clinical clinical manifestations Clinical manifestations of COVID-19 cohorts coronavirus Course COVID-19 COVID-19 cohort develop IgA antibodies IgG IgG antibodies IgG antibody IgM immune response implication independent independent of Infection Inflammatory life-threatening manifestation MIS-C N protein Neutralizing activity New coronavirus new coronavirus SARS-CoV-2 Protective reduced respiratory respiratory distress Respiratory distress syndrome Respiratory illness respiratory symptoms S protein SARS-CoV-2 SARS-COV-2 infection serological response specific antibodies syndrome the N protein the S protein
[DOI] 10.1038/s41590-020-00826-9 PMC 바로가기 [Article Type] Article

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

SARS-CoV-2 N 단백질에 의한 상 분리의 인산화는 이중 기능에 대한 생물물리학적 기초를 제시합니다

Article

Published on 2020-12-172022-09-11
Journal: Molecular Cell [Category] SARS, 유전자 메커니즘, 치료법,

1 H, 13 C, and 15 N backbone chemical shift assignments of the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein

Article

Published on 2020-12-032022-10-27
Journal: Biomolecular Nmr Assignments [Category] COVID-19,

[키워드] backbone binding Biomedical research C-terminal caused Community conserved coronavirus coronavirus 2 COVID-19 COVID19-NMR CTD Dimerization domain domain downstream drug target in viral independent International intrinsically involved linker N protein N-terminal RNA-binding domain NMR novel coronavirus SARS-CoV-2 NTD nucleic acid nucleocapsid nucleocapsid protein oligomerization outbreak pandemic Protein Protein druggability Replication respiratory Respiratory disease RNAs SARS-CoV-2 SARS-CoV-2 nucleocapsid Solution NMR-spectroscopy structural protein Support the N protein the SARS-CoV-2 Transcription Viral protein viral RNA genome
[DOI] 10.1007/s12104-020-09995-y PMC 바로가기 [Article Type] Article

1 H, 13 C, and 15 N backbone chemical shift assignments of the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein

Article

Published on 2020-12-032022-10-27
Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS,

[키워드] backbone binding Biomedical research C-terminal caused Community conserved coronavirus coronavirus 2 COVID-19 COVID19-NMR CTD Dimerization domain domain downstream drug target in viral independent International intrinsically involved linker N protein N-terminal RNA-binding domain NMR novel coronavirus SARS-CoV-2 NTD nucleic acid nucleocapsid nucleocapsid protein oligomerization outbreak pandemic Protein Protein druggability Replication respiratory Respiratory disease RNAs SARS-CoV-2 SARS-CoV-2 nucleocapsid Solution NMR-spectroscopy structural protein Support the N protein the SARS-CoV-2 Transcription Viral protein viral RNA genome
[DOI] 10.1007/s12104-020-09995-y PMC 바로가기 [Article Type] Article

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

SARS-CoV-2 뉴클레오캡시드 인단백질에 의한 RNA 인식의 구조적 기초

Research Article

Published on 2020-12-022022-08-13
Journal: PLoS Pathogens [Category] Medicine and Health Sciences, MERS, SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antiviral strategy arginine atomic atomic models Author bind binding binding site C-terminal causative agent characterized complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease dimeric domain double-stranded RNA ENCODE envelope full length Genome Interaction intrinsically involved Like lysines membrane N protein N proteins N-terminal N-terminal domain new SARS-CoV-2 NMR NMR spectroscopy nonstructural proteins nucleocapsid other coronaviruses pandemic Proteins provided respiratory ribonucleoprotein RNA RNA genome RNA virus SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-stranded single-stranded positive-sense spike structural protein structural proteins subsequent supported the N protein the SARS-CoV-2 the SARS-CoV-2 virus Viral viral genome viral membrane virion virion assembly
[DOI] 10.1371/journal.ppat.1009100 PMC 바로가기 [Article Type] Research Article

Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques

면역 정보학 및 구조 기반 약물 발견 기술을 사용하여 잠재적 치료제를 위한 SARS-CoV2 뉴클레오캡시드 단백질 표적화

Article

Published on 2020-12-012022-09-11
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료법, 치료제,

[키워드] Analysis antigens approach B-cell B-cell epitope B-cell epitopes bioinformatics candidate complex coronavirus Coverage COVID-19 Critical docking Drug discovery epitope Epitope-based vaccine Epitopes help identify IFN-γ Immunity Immuno-informatics induce inhibitor leucocyte life cycle molecular dynamics Molecular dynamics simulation N protein N-protein N-terminal domain non-allergenic non-toxic nucleocapsid nucleocapsid protein Occurrence Protein ribonucleoprotein SARS-CoV2 SARS-CoV2 infection sequence Stage Structure T-cell epitope T-cell epitopes targeting the N protein therapeutic intervention therapeutic interventions therapeutic option therapeutic options Vaccine Viral viral genome viral life cycle zidovudine zidovudine triphosphate
[DOI] 10.1016/j.biopha.2020.110914 PMC 바로가기 [Article Type] Article

Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies

SARS-CoV-2 스파이크 대 핵단백질 항체 반응의 변화는 인구 기반 혈청 유병률 연구에서 감염 추정에 영향을 미칩니다

Pathogenesis and Immunity

Published on 2020-11-032022-09-10
Journal: Journal of Virology [Category] 진단, 치료법, 치료제,

[키워드] acute infection acute phase acute respiratory syndrome acute respiratory syndrome coronavirus anti-N antibodies anti-N antibody anti-S antibody anti-S IgG Antibody binding Antibody detection Antibody Response Antibody responses Antigen assays binding change characterization Cohort cohorts conformational coronavirus Critical enrolled epitope Epitopes estimate evaluate evaluated General population generate greater Impact individual Infection Luminex assay monomer monomeric N protein N protein assay nucleocapsid nucleoprotein Patient population study Postinfection Protein ranged reduction in respiratory response responses responses against S protein S protein trimer S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sera Serological assay serology Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly more spike subjects Switzerland the antibody response the N protein the S protein trimer trimeric trimeric S protein vaccine-induced antibody response viral S was reduced
[DOI] 10.1128/JVI.01828-20 PMC 바로가기 [Article Type] Pathogenesis and Immunity

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Article

Published on 2020-10-292022-10-06
Journal: Blood [Category] SARS, 진단,

[키워드] activate Activation acute respiratory syndrome Alternative pathway animal antibody APC Atypical blocked C3c catastrophic cells clinical manifestation complement Complement pathway contagious coronavirus COVID-19 Direct disease end-organ end-organ damage endothelial damage Evidence explain Human Hypothesis in vitro inactivation Injury killing mechanism mice mitigate Myocardial infarction Prevent renal respiratory virus SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins Spike protein stroke subunit supernatant syndrome target cells the N protein the SARS-CoV-2 thrombosis Trigger upstream uremic syndrome
[DOI] 10.1182/blood.2020008248 PMC 바로가기 [Article Type] Article