translational

[키워드] addition analogy antifungal drug resistance approach approaches ATP-binding cassette transporter azole azole drug azole drugs binding binding site Biosynthesis biosynthetic biosynthetic pathway Candida caspofungin Cdr1 component components compounds defined demonstrated described drug drug treatment drugs enzyme Enzymes ERG ergosterol Evidence expression expression of gene fluconazole form Frequency functional gene encoding Genes genes encoding genomic Impact induce interfere intrinsic involved lead Lipid lipids master regulator membrane membrane protein Membrane proteins membrane transporter membranes modulate mutant Mutation network overlap overproduction pathogenic yeast pathway Perspective producing Protein protein-encoding gene Proteins regulate regulated Regulatory regulatory network required resistant mutant Saccharomyces cerevisiae Sterol susceptibility synthesis target target gene Target genes targets therapy transcription factor transcriptional Transcriptomic analyses transcriptomic analysis translational Transport Treatment wild-type
[DOI] 10.1371/journal.pgen.1009582 PMC 바로가기 [Article Type] Research Article