Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescentsSARS-CoV-2 회복기의 장기 추적 및 예방 접종 중 스파이크 및 뉴클레오캡시드 특이적 면역의 역학Article Published on 2022-01-102022-09-10 Journal: Nature Communications [Category] 진단, 치료법, [키워드] Anti-viral immunity antibody antibody levels Antibody titers Asymptomatic BNT162b2 BNT162b2 mRNA boost circulating convalescent convalescent individual convalescent individuals correlated Decline declined delayed response Dynamics follow-up period Frequency Immunity increase in individual Infection long-lasting Long-term follow-up mild SARS-CoV-2 infection mRNA naïve vaccinees neutralizing antibody titers nucleocapsid Outcomes research responded to vaccination SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific T cells selective specific immunity spike strength T cell T cell response T cells vaccination viral infection virus-neutralizing antibody waning immunity [DOI] 10.1038/s41467-021-27649-y PMC 바로가기 [Article Type] Article
Different decay of antibody response and VOC sensitivity in naïve and previously infected subjects at 15 weeks following vaccination with BNT162b2BNT162b2 백신 접종 후 15주에 경험이 없는 피험자와 이전에 감염된 피험자에서 항체 반응 및 VOC 감수성의 상이한 붕괴Research Published on 2022-01-082022-09-10 Journal: Journal of Translational Medicine [Category] 변종, 진단, [키워드] administration All participants antibody Antibody Response applied assays BNT162b2 boost BTN162b2 vaccine Clinical characteristics comparable COVID-19 COVID-19 vaccine cross-neutralizing antibodies D614G demonstrated dose dropped Effectiveness ELISA enrolled expected highlight IgG Immunity infected with SARS-CoV-2 investigated Italy kinetic Kinetics Kruskal–Wallis test Mild naïve naïve subject naïve subjects neutralization assays neutralization titer Neutralizing activity Neutralizing antibodies neutralizing response outcomes pandemic Participants pseudovirus RBD-specific IgG recalled recipient reducing remained Result SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 VOCs second dose second wave sensitivity subject supplementary material the SARS-CoV-2 These data two group two groups vaccination Vaccine vaccine dose variants of concern VoC waning immunity [DOI] 10.1186/s12967-021-03208-3 PMC 바로가기 [Article Type] Research
Quantifying the risk of SARS-CoV-2 reinfection over time시간 경과에 따른 SARS-CoV-2 재감염 위험 정량화Review Published on 2022-01-012022-09-11 Journal: Reviews in Medical Virology [Category] SARS, 변종, [키워드] antibody applicability baseline Care confirmed case COVID-19 database duration of follow-up enrolled Evidence evidence of healthcare worker Healthcare workers Immunity increase in knowledge large cohort methodology no evidence of pandemic participant PCR-positive Post-infection Primary infection protocol quantified Reinfection remains uncertain reported risk SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection SARS-CoV-2 infections searched Sequencing short term subset systematic review These data Vaccine-induced immunity variant waning immunity while whole genome Whole genome sequencing [DOI] 10.1002/rmv.2260 PMC 바로가기 [Article Type] Review
Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysisSARS-CoV-2 변이체에 대한 보호 예측 인자로서의 중화 항체 역가 및 부스팅의 영향: 메타 분석Meta-Analysis Published on 2022-01-012022-09-11 Journal: The Lancet. Microbe [Category] MERS, SARS, 변종, 진단, [키워드] Alpha analysed Analysis Antibody titre Beta booster vaccination correlated decrease decreases Effect Efficacy elicited Future In-vitro infected individual Infection infection with SARS-CoV-2 Medical Research Council medium Meta-analysis neutralisation neutralisation titre Neutralising activity not significantly different outcome predict predicted Predictive predictor reduced remained robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serum Severe infection shown statistical model suggested symptomatic infection titre vaccination vaccination schedule Vaccine vaccine efficacy vaccine response vaccine responses Vaccines variant variants variants of concern virus virus infection waning immunity [DOI] 10.1016/S2666-5247(21)00267-6 PMC 바로가기 [Article Type] Meta-Analysis
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil브라질에서 SARS-CoV-2 감마 변종에 의한 재감염 및 백신 돌파 후 급성 COVID-19 증후군Case Reports Published on 2022-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 치료기술, [키워드] B.1.1.33 Brazil Breakthrough infection caused convalescent serum COVID-19 COVID-19 breakthrough infection dose Efficacy Gamma Health Health personnel healthcare worker heterologous vaccine Immune escape Inactivated vaccine Infection Lineage Neutralizing antibodies neutralizing antibody Post-acute COVID-19 syndrome Reinfection SARS-CoV-2 SARS-CoV-2 variants syndrome the SARS-CoV-2 Vaccine variant VoC waning immunity whole-genome sequencing [DOI] 10.1016/j.ijid.2021.10.048 PMC 바로가기 [Article Type] Case Reports
COVID-19 Seroprevalence in Canada Modelling Waning and Boosting COVID-19 Immunity in Canada a Canadian Immunization Research Network StudyArticle Published on 2021-12-232022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] age booster dose Canada change Characteristics Coverage COVID-19 COVID-19 infection COVID-19 vaccination determine disease severity distribution estimate group Immunity Infection Infectious disease modelling mathematical mathematical epidmiology Model network reduce Seroprevalence severity Spread summer the vaccine vaccination waning immunity [DOI] 10.3390/vaccines10010017 PMC 바로가기 [Article Type] Article
Estimating the duration of seropositivity of human seasonal coronaviruses using seroprevalence studiesResearch Article Published on 2021-12-212022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] acute respiratory syndrome antibody catalytic Catalytic model children circulating coronavirus Endemic epidemiological estimate FIVE force of infection human coronavirus Immunity Infection majority offer Older persistence Reinfection SARS-CoV-2 seasonal seasonal coronavirus Seroconversion Seroprevalence viruses waning immunity [DOI] 10.12688/wellcomeopenres.16701.3 PMC 바로가기 [Article Type] Research Article
mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated RelationshipReview Published on 2021-12-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adjuvant administration all subjects article caused cellular common cold Coronaviruses COVID-19 COVID-19 vaccines cross-reactive demonstrated determine Evidence explain humoral immune response immune memory after COVID-19 disease immune memory after COVID-19 vaccination immunological mechanism Immunological memory induce late phase long-lived plasma cell long-lived plasma cells after mRNA COVID-19 vaccines memory memory B cell molecular mRNA mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA vaccine naïve pandemic produced Protective Protein relationship SARS-CoV-2 SARS-CoV-2 mRNA vaccines SARS-CoV-2 virus subject the Spike vaccination Vaccine waning immunity [DOI] 10.3390/vaccines9121503 PMC 바로가기 [Article Type] Review
Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months6개월 동안 BNT162b2 Covid-19 백신에 대한 면역 체액 반응 약화Article Published on 2021-12-092022-09-12 Journal: The New England Journal of Medicine [Category] Fulltext, MERS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome age analyses anti-Spike IgG antibody BNT162b2 BNT162b2 vaccine conducted coronavirus correlated correlation Coverage decrease determine dose Effectiveness Health care worker humoral IgG IgG antibody Immunosuppression incidence Infection less linear means men Month Neutralizing antibodies neutralizing antibody Neutralizing antibody titer Older participant Participants predictor Prospective Study response SARS-CoV-2 second dose Spearman symptomatic infection tested Vaccine vaccine dose waning immunity were used women [DOI] 10.1056/NEJMoa2114583 PMC 바로가기 [Article Type] Article
Waning Immunity after the BNT162b2 Vaccine in Israel이스라엘에서 BNT162b2 백신 후 면역 약화Article Published on 2021-12-092022-09-11 Journal: The New England Journal of Medicine [Category] MERS, SARS, 변종, 진단, [키워드] (rate ratio 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age all age group all age groups B.1.617.2 BNT162b2 BNT162b2 vaccine calculated collected confounding factors coronavirus coronavirus disease Coronavirus disease 2019 database delta variant Effectiveness eligible Immunity Infection mass vaccination National Older outbreak Poisson regression model rate of infection rate ratio receipt reduced respiratory resurgence SARS-CoV-2 SARS-COV-2 infection second dose second dose of vaccine severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease Stratification the vaccine used data vaccination Vaccine variant variant of SARS-CoV-2 waned waning immunity [DOI] 10.1056/NEJMoa2114228 PMC 바로가기 [Article Type] Article