T cell and antibody responses to SARS-CoV-2: Experience from a French transplantation and hemodialysis center during the COVID-19 pandemicSARS-CoV-2에 대한 T 세포 및 항체 반응: COVID-19 전염병 동안 프랑스 이식 및 혈액 투석 센터의 경험Article Published on 2021-02-012022-09-11 Journal: American journal of transplantation : official jou [Category] MERS, 바이오마커, 진단, [키워드] Adaptive immune response antibody Antibody Response Antibody responses Antiviral COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient differential diagnosis evaluate experience exposure to form French healthy control Hemodialysis immune response immune responses Immunity immunobiology Immunosuppressed immunosuppressive immunosuppressive therapy Infection infection and infectious agents - viral infectious agent infectious agents involved kidney kidney transplantation / nephrology monitoring: immune Nephrology Patient progression reactivity reduction Research responses risk RT-PCR SARS-CoV-2 serological seronegative severe forms of COVID-19 T cell T cell response T cell responses T cells the disease therapy translational translational research / science. Transplant virus [DOI] 10.1111/ajt.16348 PMC 바로가기 [Article Type] Article
Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease숙주 스핑고지질: COVID-19 질병 관리를 위한 SARS-CoV-2 감염 제어를 위한 관점 면역 보조제Review Published on 2021-02-012022-09-11 Journal: Prostaglandins & other lipid mediators [Category] SARS, 신약개발, 치료제, [키워드] Activation Antigen presentation Antiviral approach autophagy Bacterial infections ceramide clearance COVID 19 COVID-19 cases COVID-19 disease COVID-19 infection COVID-19 patients derivative effector immune response enzyme II epithelial cell epithelial cells expected Features fibrosis fingolimod FTY720 Host host-pathogen interactions human diseases hyper-inflammatory response Hyper-inflammatory responses IL-6 immune Immune adjuvants immune responses immunosuppressive Infection involved Lipid Lyase M1/M2 macrophages macrophages membrane-bound modulate Pathogenesis pathological outcomes pathological response phosphate promote receptor Replication respiratory SARS-CoV-2 SARS-COV-2 infection Signaling sphingolipid sphingolipids sphingosine-1-phosphate symptomatic T cell T cell response Th1 Th1 effector response. [DOI] 10.1016/j.prostaglandins.2020.106504 PMC 바로가기 [Article Type] Review
More Than Just Gene Therapy Vectors: Lentiviral Vector Pseudotypes for Serological Investigation유전자 치료 벡터 그 이상: 혈청학적 조사를 위한 Lentiviral Vector PseudotypesReview Published on 2021-01-312022-09-01 Journal: Viruses [Category] MERS, 진단, 치료기술, 치료제, [키워드] Above Analysis Anti-viral Cell culture cell entry characterization COVID-19 pandemic culture system envelope envelope protein evaluate flexibility handling immune response immune responses Infection investigation landscape lentiviral lentiviral vectors lentivirus Neutralising Antibodies neutralising antibody Outbreaks Protein pseudotype pseudotyped sequence serological Serological assay serological assays serology shown speed Surrogates target vaccination Vaccines vector Viral viral surface virus viruses [DOI] 10.3390/v13020217 PMC 바로가기 [Article Type] Review
Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine ImmunizationReview Published on 2021-01-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] addition amelioration of disease contribute current disease effective vaccine facilitate Factors Genetic immune correlate immune responses Immunity induce Infection innate immune Innate immunity Local lower risk mucosal mucosal immunity neutralizing antibody Neutralizing antibody titer Potential protection robust SARS-CoV-2 SARS-COV-2 infection severity suggested sustained T-cell immunity Th1 response Th1 responses trained immunity type I interferon type I interferons Vaccine Viral transmission [DOI] 10.3390/pathogens10020138 PMC 바로가기 [Article Type] Review
Sex differences in immune responses to SARS-CoV-2 in patients with COVID-19COVID-19 환자에서 SARS-CoV-2에 대한 면역 반응의 성별 차이Immunology & Inflammation Published on 2021-01-292022-09-12 Journal: Bioscience Reports [Category] 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine alanine aminotransferase ALT analyzed APACHE II aspartate Aspartate aminotransferase AST Biomarkers C-reactive protein C-reactive protein (CRP CD3 CD4 CD8 chronic circulating clinical feature Clinical features clinical manifestation clinical manifestations Cohort community-acquired pneumonia coronavirus correlation COVID-19 COVID-19 patient COVID-19 patients CRP Decreased diagnosed Estrogen explain female females healthy controls immune response immune responses independent independent of Infectious disease Laboratory lymphocyte male monocyte patients patients with COVID-19 Peripheral blood Physiology Prevalence proportion proportions respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 patient severity of COVID-19 Sex sex-specific specificity subset T cell Viral [DOI] 10.1042/BSR20202074 PMC 바로가기 [Article Type] Immunology & Inflammation
Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumorsSARS-CoV-2 감염에 대한 숙주 전사 반응의 메타 분석은 인간 종양에서의 발현을 나타냅니다Meta-Analysis Published on 2021-01-282022-09-01 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, [키워드] A549 activated adenocarcinoma bronchial epithelial cell Calu Calu-3 Cancer cancer cell Cancer cells Cell cell line cell line data common Data integration defined eight epithelial cells Gene regulatory networks histopathological Host immune response host response host responses Host transcriptional response IL-6 immune Immune cell infiltration immune response immune responses implicated Infection Inflammation interferon signaling lung adenocarcinoma lung cancer manifested model system Molecular biology NF-κB NHBE pathway Pathways Patient reveal SARS-CoV-2 SARS-COV-2 infection similarity subset the cell the SARS-CoV-2 Therapeutic strategies therapeutic strategy transcriptional transcriptomic Tumor Tumour immunology type II interferon Viral viral infection viral infections virus viruses [DOI] 10.1038/s41598-021-82221-4 PMC 바로가기 [Article Type] Meta-Analysis
Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in PigsImmunology Published on 2021-01-282022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] animal Antigen antigen expression antigens assessment breadth c-di-AMP adjuvant cell cultures cellular cellular response classical concerning coronavirus DCs dendritic cell dimeric employment encoding Fever FIVE hemagglutinin Host human cells humans humoral humoral and cellular immune response immune immune responses immunological induce influenza vaccines Influenza virus influenza virus H5N1 inherent monocyte monophosphate mRNA nucleoprotein offer packaged pandemic Particle Pestivirus pig polyplexes promote question receiving remained replicative replicon reported response RNA self-amplifying replicon RNA target Vaccine design virus virus replicon particle [DOI] 10.3389/fimmu.2020.622385 PMC 바로가기 [Article Type] Immunology
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys단일 세포 RNA 시퀀싱은 아프리카 녹색 원숭이의 폐에서 SARS-CoV-2 감염 역학을 보여줍니다Research Article Published on 2021-01-272022-09-10 Journal: Science Translational Medicine [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African green monkey African green monkeys Alveolar macrophages Analysis animal model animal models animals best Cell cellular debris clearance contribute coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 dataset degrade determine Factor genomic RNA green monkeys Host Host immune response host response host responses identify immune cell population immune cell populations immune responses in vivo inactivated Indicator infected cell infected cells Infection infiltrating Inflammatory response information inoculated knowledge lung Lungs Lymph node Macrophage macrophages mediastinal lymph nodes Mild mild to moderate moderate monocyte Monocyte-derived macrophages occur Pathogenesis phagocytosis pneumocyte Pneumocytes provide recruited replicate Replication respiratory respiratory tract responsible reveal RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing sequencing data severe acute respiratory syndrome Coronavirus Single-cell RNA sequencing switching therapeutic targets valuable resource Viral viral genome viral replication virus virus replication while [DOI] 10.1126/scitranslmed.abe8146 PMC 바로가기 [Article Type] Research Article
Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France일상적인 게놈 감시 동안 병원 클러스터에서 검출된 SARS-CoV-2 ORF6 결실 변이체의 특성화, 프랑스 리옹Coronaviruses Published on 2021-01-272022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 치료기술, [키워드] Analysis Care CCL2 center characterization Cluster coding collected comparable replication Cytokines Deletion deletion variant disease severity fecal Frame France genomic Genomic surveillance Health Health care high plasma level high plasma levels hospital Host immune response host immune responses immune responses Infection Inflammation Inflammatory cytokine Inflammatory cytokines interferon-stimulated gene interferon-stimulated genes MCP1 molecular MONITOR nasopharyngeal sample NF-kB NF-kB pathway no difference nosocomial nosocomial cluster Nosocomial transmission Occurrence one health Open reading frame ORF6 overexpression Patient patients hospitalized performed Ptx3 reference respiratory respiratory viruses SARS-CoV-2 sequence severe COVID-19 Stool suggested Surveillance TNFα Transmission upregulated variants viruses while wild-type [DOI] 10.1080/22221751.2021.1872351 PMC 바로가기 [Article Type] Coronaviruses
Promising Extracellular Vesicle-Based Vaccines against Viruses, Including SARS-CoV-2Review Published on 2021-01-272022-10-28 Journal: Biology [Category] COVID-19, [키워드] adjuvants Antigen display Antigen presentation antigens Antiviral B cell biogenesis biological processes cell-to-cell communication Characteristics conventional vaccine COVID-19 displaying dissemination DNA Efficiency EVs Exosomes flexible heterogeneous highlighting human cell Immune cell immune responses immunogenic profile Including induce infected cell Infection Intercellular communication limit limitation lipids mRNA overcome presenting Protein Proteins reaction Reactions RNAs Safe SARS-CoV-2 secreted simple spike strong immune response T cell the SARS-CoV-2 therapeutic agents transfer uninfected cell unique Vaccine Vaccine design Vaccines Vesicle Viral antigen Viral protein Viral proteins [DOI] 10.3390/biology10020094 PMC 바로가기 [Article Type] Review