immune responses – Page 89 – Communicable Diseases Research

Limited Specificity of Serologic Tests for SARS-CoV-2 Antibody Detection, Benin

SARS-CoV-2 항체 검출을 위한 혈청학적 검사의 제한된 특이성, 베냉

Dispatch

Published on 2021-01-012022-09-10
Journal: Emerging Infectious Diseases [Category] MERS, SARS, 진단, 치료기술,

The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization

SARS-CoV-2 Y453F 밍크 변이체는 ACE-2 친화도가 현저하게 증가하지만 항체 중화에 도전하지 않습니다

Article

Published on 2021-01-012022-09-11
Journal: The Journal of Biological Chemistry [Category] 변종, 유전자 메커니즘, 진단,

[키워드] ACE-2 acute respiratory syndrome coronavirus Affect Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 animals antibodies Antibody neutralization antigens bind Cluster Complete coronavirus coronavirus 2 decrease Denmark ELISA enzyme Frequency functional Genetic variant higher affinity Human human Angiotensin-converting enzyme Humoral immunity immune evasion immune responses immunology increase in infected individual mutant Mutation Neutralizing antibody response raised RBD receptor receptor interaction receptor structure–function. Receptor-binding domain reported residue respiratory resulting RNA RNA virus SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike gene Spike protein the receptor-binding domain the spike protein Transmission Vaccine variant Viral viral control Virology Wuhan strain Y453F
[DOI] 10.1016/j.jbc.2021.100536 PMC 바로가기 [Article Type] Article

Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab

리툭시맙으로 B 세포 표적 치료를 받는 환자에서 SARS-CoV-2 지속성을 유발하는 불일치 항원 특이적 항체 반응

Case Reports

Published on 2021-01-012022-09-11
Journal: Internal medicine (Tokyo, Japan) [Category] MERS, 진단, 치료기술, 치료법, 치료제,

Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19

사이토카인 폭풍의 특성은 COVID-19의 과염증성 내피 기능 장애를 반영합니다

Article

Published on 2021-01-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADP-ribose Adult patients age Analysis analyzed assays association attenuate Baricitinib Biomarker Biomarkers blood sample Blood samples cardiovascular cardiovascular disease characterization characterized circulating circulation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CXCL10 CXCL5 CXCL9 cytokine Cytokine storm Cytokine storms disease severity dominant dysregulation endothelial damage Endothelial dysfunction healthy control healthy controls help host inflammatory response host response Hyperinflammatory identify IFN-γ IL-10 IL-1ra IL-6 immune response immune responses increasingly Infection Inflammation Intervention marker MCP-3 mechanism Mild moderate monocyte observé Ordinal Scale Pathogenesis Patient patients hospitalized patients with COVID-19 physician platform polymerase Protein proteomic pursuit reduce reflect Regulation reliability reproducibility respiratory Result scale severe acute respiratory syndrome Coronavirus Spectrum statistically significant stratified the cytokine storm therapeutic options Vascular with COVID-19
[DOI] 10.1016/j.jaci.2020.08.031 PMC 바로가기 [Article Type] Article

Dynamic monitoring of immune function indexes in COVID-19 patients

COVID-19 환자의 면역 기능 지수의 동적 모니터링

Research Paper

Published on 2020-12-312022-09-01
Journal: Aging (Albany NY) [Category] MERS, SARS, 바이오마커, 진단,

[키워드] absolute levels allergic blood collection CD4 CD4/CD8 CD8 lymphocyte CD8 lymphocytes China Clinical characteristics conducted COVID-19 COVID-19 patient CRP diagnostic disease onset dynamic dynamic monitoring early diagnostic markers elevated elicit enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays flow cytometry Follow-up IgE IgG level IgG levels IgM immune immune function immune response immune responses LDH Lymphocytes marker nine Patient patients plasma plasma exchange remained Retrospective analysis SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgM SARS-COV-2 infection the timing Variation
[DOI] 10.18632/aging.202362 PMC 바로가기 [Article Type] Research Paper

The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19

PIKfyve 억제제 Apilimod: COVID-19에 대한 양날의 검

Opinion

Published on 2020-12-272022-09-11
Journal: Cells [Category] MERS, SARS, 치료제,

A distinct innate immune signature marks progression from mild to severe COVID-19

뚜렷한 타고난 면역 신호는 경증에서 중증 COVID-19로의 진행을 나타냅니다.

Article

Published on 2020-12-262022-09-11
Journal: Cell Reports Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] appearance CCL3 CCL4 CD16 CD169 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytometry emergency granulopoiesis healthy individuals identify IFN-γ immune responses immune signature Inflammation inflammatory phenotype Inflammatory response Inflammatory responses innate immune innate immune response innate response mass cytometry mechanism Mild mild COVID-19 patient mild COVID-19 patients mild or severe Covid-19 MIP1α monocyte Monocytes observé Patient progression proteomics sampling SARS-CoV-2 severe COVID-19 severe disease severe patients sialoadhesin sialoadhesin. signature Stage stages sustained symptom onset targeted intervention targeted interventions trajectory
[DOI] 10.1016/j.xcrm.2020.100166 PMC 바로가기 [Article Type] Article

Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19

세로 전사체 분석은 COVID-19에서 회복하는 동안 강력한 T 세포 면역을 보여줍니다

Article

Published on 2020-12-242022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Analysis AP-1 Clinical features Clinical stages convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 creation differentially expressed differentiation disease downregulated driven by event Genome informatics Humoral immunity immune protection immune regulation immune response immune responses Immunity indicated Infectious diseases long non-coding RNA longitudinal Messenger RNA messenger RNAs microRNA MicroRNAs miRNAs mononuclear cell mRNAs occurred Patient PBMC performed Peripheral blood regulatory network rehabilitation respiratory RNA sequencing robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway significantly T cell T-cell activation Transcriptome Treatment type I interferon type I interferon response understanding
[DOI] 10.1038/s41392-020-00457-4 PMC 바로가기 [Article Type] Article

Physiology of Midkine and Its Potential Pathophysiological Role in COVID-19

Physiology

Published on 2020-12-222022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

[키워드] angiotensin autoimmune condition autophagy cascade cause cellular clinical complication coagulative coronary syndrome COVID-19 cytokine dependent on Disseminated intravascular coagulation distress dysregulation Effect effector cells elicited facilitate fibrinolytic growth factor highlight Hyperactivation hypoxia immune immune responses include increases in induce Inflammatory literature mechanism mechanisms mediators of inflammation Midkine myocarditis NETs, autophagy neutrophil infiltration Neutrophils New coronavirus Occurrence organs pathogen clearance pathological condition pathophysiological physiological Physiology Potential pro-inflammatory cytokines pulmonary fibrosis receptor Renin replicate response role SARS-CoV2 SARS-CoV2 infection severe cases severe pneumonia similarity System target tissues Thromboembolism tissue tissue damage virus entry
[DOI] 10.3389/fphys.2020.616552 PMC 바로가기 [Article Type] Physiology

A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine

면역원성이 높고 효과적인 홍역 바이러스 기반 Th1 편향 코로나19 백신

530

Published on 2020-12-222022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 진단, 치료기술,

[키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Adaptive immunity addition analyzed antibody antiviral efficacy Arm backbone candidate caused CD4 CD8 Coronavirus-2 country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines death deaths effective effective immunity Effective vaccines effort experiments expressing full-length S protein functional immune response genomic position gravity hamster identify IgG antibody immune immune responses Immunity immunogenic immunopathology in vivo induce insertion killing measles measles vaccine platform measles virus mice modulated mouse mouse-adapted SARS-CoV-2 multifunctional Neutralizing Patient Protective public health respiratory response S protein S protein expression Safe SARS-CoV-2 SARS-CoV-2 spike glycoprotein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Significance significantly lower situation solution spike glycoprotein Spread Support T cell T cell response T cell responses Th1 immune bias the SARS-CoV-2 Threats vaccination Vaccine vaccine candidate variant virus virus load yielding
[DOI] 10.1073/pnas.2014468117 PMC 바로가기 [Article Type] 530