Promising inhibitors of main protease of novel corona virus to prevent the spread of COVID-19 using docking and molecular dynamics simulation도킹 및 분자 역학 시뮬레이션을 사용하여 COVID-19의 확산을 방지하기 위해 새로운 코로나 바이러스의 주요 프로테아제의 유망한 억제제Article Published on 2021-08-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 치료제, [키워드] 2019-nCoV Antiviral best binding energy caused change China complexes Compound compounds coronavirus coronavirus disease coronavirus disease-2019 COVID-19 determine docking Efficiency energy health emergency Human in silico Approach Infection Infectious disease inhibit inhibitor inhibitors lead matter MD simulations MM-GBSA molecular dynamics Molecular dynamics simulation molecular dynamics simulations novel corona virus Novel coronavirus pandemic parameter performed Prevent protease room temperature SARS-CoV-2 SARS-COV-2 infection screened Spread spread of COVID-19 temperature thermodynamic Till Viral viral replication virus was determined WHO Wuhan Zinc ZINC database [DOI] 10.1080/07391102.2020.1779131 PMC 바로가기 [Article Type] Article
One Year of the COVID‐19 Pandemic. What Do We Know and What Is Yet to Come? — The Summarising ReviewPublic Health Archive Published on 2021-07-302022-10-30 Journal: International Journal of Public Health [Category] COVID-19, MERS, [키워드] 2019-nCoV Analysis article average clinical manifestation collected Comorbidity concentrations conducted coronavirus COVID-19 COVID‐19 described deviation Epidemic evaluate examined Frequency hospitalized patients Laboratory Laboratory test marker organism pandemic pathophysiology performed Pneumonia public health required Research review SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection the disease Treatment Vaccines virus virus infection Year [DOI] 10.3389/ijph.2021.1603975 PMC 바로가기 [Article Type] Public Health Archive
Novel coronavirus 2019-nCoV (COVID-19): early estimation of epidemiological parameters and epidemic size estimatesArticles Published on 2021-07-192022-10-29 Journal: Philosophical Transactions of the Royal Society B: [Category] COVID-19, SARS, [키워드] 2019-nCoV 95% CI arising ascertainment rate basic reproductive number case ascertainment China coronavirus country COVID-19 pandemic Epidemic epidemiological estimate greater Infection information international travel novel Novel coronavirus pandemic parameter prevented regions SARS-CoV-2 significantly the epidemic Transmission Transmission model Wuhan Wuhan, China [DOI] 10.1098/rstb.2020.0265 PMC 바로가기 [Article Type] Articles
The correlation between mental health status, sleep quality, and inflammatory markers, virus negative conversion time among patients confirmed with 2019-nCoV during the COVID-19 outbreak in China: An observational studyObservational Study Published on 2021-07-092022-10-05 Journal: Medicine [Category] SARS, 임상, [키워드] 2019 coronavirus disease 2019-nCoV Analysis Anxiety Clinical characteristics collected conducted correlation COVID-19 COVID-19 outbreak cross-sectional survey Depression depressive dimension disorder immune function index indicated Inflammation Inflammatory inflammatory markers Inflammatory response information Laboratory Lymphocyte count mental health Negative conversion neutrophil count NLR participant Patient Pittsburgh platform positively correlated problem problems Psychological Quality questionnaire reported Self-Rating Depression Scale significant difference Sleep Sleep disturbance sleep quality spread to Stress Symptom total score virus was increased [DOI] 10.1097/MD.0000000000026520 PMC 바로가기 [Article Type] Observational Study
Significance of peripheral blood indexes in differential diagnoses of SARS-CoV-2 and New Bunia virusSARS-COV-2 및 New Bunia 바이러스의 감별 진단에서 말초 혈액 지수의 중요성Article Published on 2021-07-082022-08-31 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] 2019-nCoV absolute lymphocyte Biomarkers Blood C-reactive protein C-reactive protein (CRP CD4 characteristic clinical Clinical data collected control group COVID-19 COVID-19 patient CRP Cytokines diagnostic value differential diagnose differential diagnosis Fever greater groups healthy control hospitalized patients IL-6 infections Infectious diseases initial initial stage Laboratory lymphocyte New Outcomes research parameters Patient PCT Peripheral blood procalcitonin receiver receiver operating characteristic Respiratory tract diseases Retrospective analysis ROC ROC Curve ROC curves SARS-CoV-2 Significance significantly syndrome T lymphocyte thrombocytopenia TNF-α virus virus infection was performed WBC [DOI] 10.1038/s41598-021-93519-8 PMC 바로가기 [Article Type] Article
The Influence of Corticosteroids, Immunosuppressants and Biologics on Patients With Inflammatory Bowel Diseases, Psoriasis and Rheumatic Diseases in the Era of COVID-19: A Review of Current EvidenceImmunology Published on 2021-07-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] 2019-nCoV anti-TNF antiviral immune response Autoimmune benefit biologics Corticosteroids COVID-19 COVID-19 epidemic current Cytokine storm death decision Hospitalization ICU Immune-mediated inflammatory diseases immunocompromised status immunomodulator immunomodulators Immunosuppressant Infection Inflammatory bowel disease influence lower risk mechanism Mortality pathway Patient patients patients treated potential risk psoriasis review rheumatic disease risk SARS-CoV-2 significant changes in suggested systemic corticosteroid therapy treated use of corticosteroids Ventilation [DOI] 10.3389/fimmu.2021.677957 PMC 바로가기 [Article Type] Immunology
COVID-19 global pandemic planning: Presence of SARS-CoV-2 fomites in a university hospital settingCOVID-19 세계적 대유행 계획: 대학 병원 환경에서 SARS-CoV-2 매개체의 존재Original Research Published on 2021-07-042022-09-11 Journal: Experimental Biology and Medicine [Category] SARS, 유전자 메커니즘, [키워드] 2019-nCoV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed CDC Chain Reaction clinician collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical effort evaluate Evidence fomites global pandemic globe healthcare hospital iatrogenic limit mechanism molecular assays Particle Patient patients Perspective polymerase chain polymerase chain reaction positive Presence Prevent respiratory Respiratory droplets RT-qPCR Sample SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 transmission severe acute respiratory syndrome Coronavirus Spread surface areas SYBR Green tested the Spike Topic Transmission transmitted university hospital Viral viral culture virus Volume with COVID-19 [DOI] 10.1177/15353702211024597 PMC 바로가기 [Article Type] Original Research
Different incidences of acute kidney injury (AKI) and outcomes in COVID-19 patients with and without non-azithromycin antibiotics: A retrospective study비 아지스로마이신 항생제를 사용하거나 사용하지 않는 COVID-19 환자의 급성 신장 손상(AKI) 발생률 및 결과: 후향적 연구Article Published on 2021-07-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료제, [키워드] 2019-nCoV 95% confidence interval acute kidney Acute kidney injury acute renal failure addition administration Admission Adult patients adverse events AKI angiotensin Angiotensin II angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors Antibiotics association blockers caused Comorbidities Comorbidity concomitant infection conducted coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 COVID-19 patient criteria death determine diabete diabetes Effect evaluate the effect help Hospitalization hypertension ICU ICU admission incidence incidence rate indication indications initiated intensive care intensive care unit Kidney injury Lopinavir Lopinavir/ritonavir medication medications Mortality multivariable logistic regression nCoV Novel coronavirus Odds ratio outbreak outcome outcomes Participants Patient patients patients hospitalized poor prognosis Predictive Primary outcome receptor renal renal failure Retrospective study ribavirin Ritonavir SARS-CoV-2 secondary outcome severity was used with COVID-19 [DOI] 10.1002/jmv.26992 PMC 바로가기 [Article Type] Article
A patient with human coronavirus NL63 falsely diagnosed with COVID-19; Lesson learned for the importance of definitive diagnosisCOVID-19로 잘못 진단된 인간 코로나바이러스 NL63 환자; 확실한 진단의 중요성에 대해 배운 교훈Case Reports Published on 2021-07-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료기술, 치료제, [키워드] 2019-nCoV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 condition Contamination coronavirus coronavirus disease Coronavirus disease 2019 Corporation COVID-19 cross-reaction cycle threshold definitive diagnosis detection diagnosed diagnosed with COVID-19 Diagnosis disease False positive false-negative False-positive genome sequence Genome sequences gold gold standard HCoV HCoV-NL63 hospital ward Human human coronavirus Human rights Isolation issue Japan Laboratory testing lesson likelihood NL63 nucleic acid Nucleic acid detection Patient PCR PCR test PCR testing physician positive Prevent primer problem problems reaction recognize reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread target region the disease TOYOBO was obtained [DOI] 10.1016/j.jiac.2021.05.001 PMC 바로가기 [Article Type] Case Reports
What is the status of nucleic acid contamination in 2019-nCOV vaccination sites? Can it be avoided?Original Paper Published on 2021-06-292022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV Can collected Contamination evaluate the effect hospital Intervention nucleic acid Pollution polymerase chain positive rate positive result Sample vaccination Vaccine was used [DOI] 10.1017/S0950268821001394 PMC 바로가기 [Article Type] Original Paper