Inactivated Whole-virus Vaccine Triggers Low Response Against SARS-CoV-2 Infection Among Renal Transplant Patients: Prospective Phase 4 Study Results비활성화된 전체 바이러스 백신은 신장 이식 환자에서 SARS-CoV-2 감염에 대한 낮은 반응을 유발합니다: 예상 4상 연구 결과Clinical Trial Published on 2022-04-012022-09-11 Journal: Transplantation [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, [키워드] A significant reduction acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adverse reaction Adverse reactions Against Analysis antibody Antibody Response Antibody responses clinical effectiveness Cohort CoronaVac coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death elicit first dose humoral Humoral response IgG antibodies IgG antibody inactivated incidence of COVID-19 increase individual intramuscular dose kidney transplant recipients lack lethality rate lethality rates mRNA vaccine Neutralizing antibodies occurred Patient patients phase 4 proportion Prospective Prospective trial reactogenicity recipient recipients reduced reduction in remained reported respiratory response Result SARS-CoV-2 second dose Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus single-center solid-organ transplant Transplant transplantation Trigger vaccination vaccination schedule Vaccine [DOI] 10.1097/TP.0000000000004036 PMC 바로가기 [Article Type] Clinical Trial
Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals코로나바이러스 질병 2019 메신저 RNA 백신 면역억제된 개인의 면역원성Article Published on 2022-04-012022-09-11 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 19 vaccine 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody Antibody Response Antibody responses binding CD4 CD8 T-cell coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 mRNA Vaccination cross-reactivity function Immunocompromised immunocompromised individuals immunogenicity immunosuppressive increased mortality individual individuals Infection interferon interferon-γ lead messenger Messenger RNA mRNA mRNA vaccination mRNA vaccine Neutralizing reduce reduced regimen respiratory response RNA SARS SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus T cells therapy These data vaccine immunogenicity Viral viral clearance Viral variants [DOI] 10.1093/infdis/jiab569 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of inactivated COVID-19 vaccine in health care workers의료 종사자에서 비활성화된 COVID-19 백신의 안전성 및 면역원성Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] administration adverse event Adverse reaction Adverse reactions age antibodies antibody Antibody Response Antibody responses appear booster doses comparable Concentration conducted convalescent plasma convalescent serum CoronaVac coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine domain dose Effective vaccines geometric mean geometric mean concentration GMC Health care Health care worker health care workers hospital IgG immunization immunogenicity Immunoglobulin Immunoglobulin G inactivated Inactivated vaccine incidence Infection injection Injection-site pain Local myalgia N protein nucleocapsid nucleocapsid protein Pain pandemic participant positive prospective cohort study Protein RBD Receptor-binding domain recruited regimen Safe Safety SARS-CoV-2 Serious Adverse Event Serious Adverse Events seroconversion rate seroconversion rates Spike protein tested the RBD Total total antibodies total antibody U/mL Vaccine virus waned [DOI] 10.1002/jmv.27458 PMC 바로가기 [Article Type] Article
Dynamic observation of SARS-CoV-2 IgM, IgG, and neutralizing antibodies in the development of population immunity through COVID-19 vaccinationSARS-CoV-2 IgM, IgG, 중화항체의 코로나19 예방접종을 통한 집단면역 발달의 동적 관찰Article Published on 2022-04-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] antibody Antibody responses assays assessment booster dose booster vaccination changes in chemiluminescent immunoassay CLIA convalescent Conventional conventional virus neutralization test coronavirus coronavirus disease coronavirus disease-2019 correlation COVID-19 COVID-19 convalescent COVID-19 vaccination COVID-19 vaccine criterion cVNT diagnostic discharge dynamic ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays evaluated FIVE foundation guide humoral immune response IgG IgM immune immune response Immunity include indicated individual NAb assay NAbs neutralization test Neutralizing neutralizing antibody observation Patient population immunity positive rate ranged Rapid reached receipt SARS-CoV-2 IgM SARS-COV-2 infection second dose Sensitivity and specificity serological seropositivities Seropositivity serum Serum neutralizing antibody specific IgM the antibody response vaccination Vaccine virus neutralization test Volunteer volunteers was used [DOI] 10.1002/jcla.24325 PMC 바로가기 [Article Type] Article
Diminishing Immune Responses against Variants of Concern in Dialysis Patients 4 Months after SARS-CoV-2 mRNA VaccinationSARS-CoV-2 mRNA 백신 접종 4개월 후 투석 환자의 우려 변종에 대한 면역 반응 감소Article Published on 2022-04-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] (alpha acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor Antibody Response Antibody responses Beta BNT162b2 BNT162b2 vaccine booster booster dose cellular Cellular and humoral responses Chronic hemodialysis Cohort concern coronavirus coronavirus disease COVID-19 Delta detectable dialysis domain examined Gamma Germany had no healthy donors Hemodialysis humoral immune response Humoral response IgG immune immune response immune responses Immunocompromised increased risk interferon interferon-γ longevity of immune response Month mRNA mRNA vaccination neutralization capacity Patient Pfizer-BioNTech receive reduced reported respiratory respiratory infections response Saliva SARS-CoV-2 SARS-CoV-2 variant second vaccination serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease T-cell responses vaccination vaccine-preventable diseases variant variants variants of concern viruses zoonoses [DOI] 10.3201/eid2804.211907 PMC 바로가기 [Article Type] Article
SARS-CoV-2 vaccination response in patients with autoimmune hepatitis and autoimmune cholestatic liver disease자가면역 간염 및 자가면역 담즙정체성 간질환 환자에서 SARS-CoV-2 예방접종 반응Observational Study Published on 2022-04-012022-09-11 Journal: United European gastroenterology journal [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] absence antibody antibody levels Antibody Response Antibody responses Antibody titer Antibody titers Autoimmune Autoimmune hepatitis booster Cellular immune response chronic liver disease Cohort contributed Control COVID-19 vaccination declined demonstrated DiaSorin healthy control humoral immunization immunoassay Immunosuppression individuals LIAISON liver Liver disease marker observational study Patient patients positive serology primary biliary cholangitis primary sclerosing cholangitis PSC responders Roche SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine sclerosing cholangitis second vaccination Seroconversion significantly Specific T-cell response spike-specific T-cell response subset T-cell Response undetectable vaccination [DOI] 10.1002/ueg2.12218 PMC 바로가기 [Article Type] Observational Study
Humoral and cellular immunogenicity of SARS-CoV-2 vaccines in chronic lymphocytic leukemia: a prospective cohort study만성 림프구성 백혈병에서 SARS-CoV-2 백신의 체액 및 세포 면역원성: 전향적 코호트 연구Clinical Trial Published on 2022-03-222022-09-11 Journal: Blood advances [Category] MERS, SARS, 변종, 임상, 진단, [키워드] Absolute lymphocyte count accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antibody Response Antibody responses assays bead-based multiplex immunoassay binding cellular characterization chronic chronic lymphocytic leukemia clinical benefit CLL CLL patient Cohort coronavirus COVID-19 mortality demonstrated develop dose elicited framework function functional IgG immunoassay induce interferon interferon-γ leukemia lymphocyte Lymphocytic leukemia molecular mechanism molecular mechanisms mRNA-based vaccine outcome Patient Previous studies previous study prospective cohort study provide RBD Receptor binding domain Registered respiratory response rate responses SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine Serologic response serologic responses severe acute respiratory syndrome Coronavirus Spike-specific T-cell responses T-cell T-cell Response T-cell responses tested Therapies therapy treatment-naïve patient treatment-naïve patients Trial vaccination Vaccine variant was performed wild-type [DOI] 10.1182/bloodadvances.2021006627 PMC 바로가기 [Article Type] Clinical Trial
Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms코로나바이러스 질환 2019 및 신경학적 증상이 있는 환자의 혈청 및 뇌척수액에서 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 항체 반응Article Published on 2022-03-152022-09-11 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses Central nervous system cerebrospinal fluid clinical variables coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CSF disease severity elevated highest IgG Immunoglobulin Immunoglobulin G independent Level marker neurological Neurological symptom Neurological symptoms neuronal Patient Predictive Predictive value respiratory response SARS-CoV-2 SARS-CoV-2 IgG serological serology serum severe acute respiratory syndrome Coronavirus Spike protein tested virus spike protein were assessed [DOI] 10.1093/infdis/jiab153 PMC 바로가기 [Article Type] Article
Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern전염병 초기에 COVID-19 환자의 혈청은 우려의 변이에 대한 교차 중화의 제한된 증거를 보여줍니다Article Published on 2022-03-102022-09-11 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibody Antibody Response Antibody responses Beta chemokine chemokines clinical symptom Clinical symptoms Cohort cohort of patient Concentration coronavirus COVID-19 patient Critical critical state cross-neutralization cytokine Cytokines Delta detectable determine Evidence evidence of examined highlight Human human serum Immune status infected with SARS-CoV-2 Infection mechanism Mild mild to moderate moderate moderate infections moderate to severe Neutralizing antibodies neutralizing antibody pandemic pathogen Patient plasma Re-infection Recovered COVID-19 patients respiratory SARS-CoV-2 sera serum serum and plasma severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case severe cases severe disease Severity of infection significantly increased variants variants of concern variety [DOI] 10.1038/s41598-022-07960-4 PMC 바로가기 [Article Type] Article
Long-Term Antibody Response and Vaccination Efficacy in Patients with COVID-19: A Single Center One-Year Prospective Study from the Czech RepublicCOVID-19 환자의 장기 항체 반응 및 예방 접종 효능: 체코의 단일 센터 1년 전향적 연구Article Published on 2022-03-042022-09-11 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] Admission analyzed antibody Antibody Response Antibody responses antigen detection center characterized Cohort courses COVID-19 patient COVID-19 patients Czech Republic diagnosis of SARS-CoV-2 diagnostic disease Dynamics ELISA enrolled Evidence high correlation hospitalized patient hospitalized patients IgA IgG IgG antibodies IgG antibody IgG level IgG levels IgM and IgG indicated Infection Laboratory neutralization test Patient PCR performed positive positive antibody response positive antibody responses Prospective Prospective Study Reinfection response Sample SARS-CoV-2 SARS-COV-2 infection sensitivity serological data serology significantly specific antibodies specific antibody sustained the SARS-CoV-2 vaccination Virus neutralization virus neutralization test VNT [DOI] 10.3390/v14030526 PMC 바로가기 [Article Type] Article