The Yin and the Yang of Transformative Research During the COVID-19 Pandemic—A PerspectiveCOVID-19 팬데믹 기간 동안의 변혁적 연구의 음과 양 - 관점Pediatrics Published on 2021-06-242022-09-10 Journal: Frontiers in Pediatrics [Category] 비임상, [키워드] adaptive animal models approach basic and clinical sciences breath broad scientific training capture Clinical research clinical trial complex disease COVID-19 COVID-19 pandemic develop domain effort facilitate highlight humanized limitation methodology mitigate model system NIH partnership pathophysiology pediatric Perspective Precision rare and complex disease Research researcher seamless singular Systems biology training & development transformative team science Translational research [DOI] 10.3389/fped.2021.650302 PMC 바로가기 [Article Type] Pediatrics
The effect of COVID19 pandemic restrictions on an urban rodent population도시 설치류 인구에 대한 COVID19 전염병 제한의 영향Article Published on 2021-06-212022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, [키워드] absence affected binary data capture captures changes in city collected COVID-19 COVID19 declined defined directional driven by Effect Frequency geographical distribution Government health authorities implication Invasive species Local local government lockdown management measure pandemic Population Population dynamics populations presence or absence public health authorities public health authority rapid increase RATs Relocation reported resource resources rodent rodents spread of COVID-19 Urban ecology [DOI] 10.1038/s41598-021-92301-0 PMC 바로가기 [Article Type] Article
A flow cytometry-based assay for serological detection of anti-spike antibodies in COVID-19 patientsCOVID-19 환자에서 항-스파이크 항체의 혈청 학적 검출을위한 유세포 분석법 분석Protocol Published on 2021-06-192022-09-01 Journal: STAR protocols [Category] MERS, SARS, 진단, 치료기술, [키워드] Abstract anti-spike antibody antibody capture Cell Cell Biology cell surface Cloning complement Complete coronavirus coronavirus 2019 disease COVID-19 COVID-19 patient Cytometry detect Early detection eGFP Express Flow flow cytometry Flow Cytometry/Mass Cytometry full-length SARS-CoV-2 full-length SARS-CoV-2 spike protein Health Sciences immunology infected individual infected individuals insertion limit management Molecular biology patients with COVID-19 PCR-based assays Plasmid protocol public health S protein SARS-CoV-2 spike SARS-CoV-2 spike protein serological Serological assay serological assays specific antibodies specific antibody Spike protein the cell the S protein transduced transfection transfer Transmission Viral viral particle Viral particles [DOI] 10.1016/j.xpro.2021.100671 PMC 바로가기 [Article Type] Protocol
SARS-CoV-2 Simulations Go Exascale to Capture Spike Opening and Reveal Cryptic Pockets Across the ProteomeSARS-CoV-2 시뮬레이션은 엑사스케일을 사용하여 스파이크 오프닝을 캡처하고 프로테옴 전체에 비밀 포켓을 나타냅니다.Article Published on 2021-06-122022-09-10 Journal: Nature chemistry [Category] SARS, 변종, 치료제, [키워드] antivirals capture closed structures complex conformational change conformational changes distributed computing Epitopes expand explain Folding@home homologue immune immune evasion Infection less mechanism modulate observé open opening pocket predict Probability Protein protein structures Proteins proteome Quantitative Receptor binding Replication SARS-CoV-2 Simulation spike Structure suppression Viral [DOI] 10.1038/s41557-021-00707-0 PMC 바로가기 [Article Type] Article
Geographic and demographic heterogeneity of SARS-CoV-2 diagnostic testing in Illinois, USA, March to December 2020미국 일리노이에서 SARS-COV-2 진단 테스트의 지리적 및 인구 통계 이질성 2020 년 3 월에서 12 월까지Research Published on 2021-06-102022-09-10 Journal: BMC Public Health [Category] MERS, SARS, 치료기술, [키워드] age allocation black capture Case fatality rate case fatality ratio Course COVID-19 COVID-19 disease COVID-19 pandemic demographic characteristics demographic group demographic groups diagnostic diagnostic testing epidemic wave evade evaluate fatality First wave fraction Geographic Geographic difference Geographic differences groups heterogeneity heterogeneous Illinois Infection Infection fatality rate initial MONITOR per day Population populations Racial disparities reduce Region regions remained resource Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 testing SARS-CoV-2 transmission shifting Spread supplementary material Surveillance tested the epidemic the United State United States USA Volume while white [DOI] 10.1186/s12889-021-11177-x PMC 바로가기 [Article Type] Research
Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV‐CATCHER): A customizable purification assay designed for small‐RNA biomarker identification and evaluation of circulating small‐EVsTechnical Report Published on 2021-06-032022-10-29 Journal: Journal of Extracellular Vesicles [Category] COVID-19, MERS, [키워드] Analysis Biomarker capture cellular circulating circulating miRNAs Cohort convalescent sera Critical current demonstrated disease severity downregulated EVs exosome purification extracellular vesicle Extracellular vesicles highlight Hospitalized Human plasma IgG titers in vitro Isolation micro‐RNA profiling miRNA biomarker Neutralizing nucleic acids Patient patients physical purification Release SARS‐CoV‐2 selective sensitivity Sequencing sequencing data significantly subset TEM tissues transmission electron microscopy were used western blotting whole serum [DOI] 10.1002/jev2.12110 PMC 바로가기 [Article Type] Technical Report
Data management during COVID-19 outbreak response in Ghana: a reference laboratory perspective on key issues and measures가나의 COVID-19 발생 대응 중 데이터 관리: 주요 문제 및 조치에 대한 참조 실험실 관점Special Article Published on 2021-06-012022-09-10 Journal: Ghana Medical Journal [Category] MERS, SARS, 치료기술, [키워드] Analysis capture caused confirmed case confirmed cases country COVID-19 COVID-19 outbreak COVID-19 pandemic data entry data management database deaths feedback form forms funding global health Government Health IMPROVE information initial Laboratory laboratory diagnosis management measure Medical research Memorial middle pandemic Perspective resolved SARS-CoV-2 subject supported Surveillance test results tested the disease Transmission university with COVID-19 [DOI] 10.4314/gmj.v55i2s.8 PMC 바로가기 [Article Type] Special Article
Vertical Flow Cellulose-Based Assays for SARS-CoV-2 Antibody Detection in Human Serum인간 혈청에서 SARS-CoV-2 항체 검출을 위한 수직 유동 셀룰로스 기반 분석Article Published on 2021-05-282022-09-11 Journal: ACS Sensors [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody Antibody test Antigen antigen tests approval capture Cellulose cellulose-binding domain chemiluminescence immunoassay clinical sample clinical samples complement Coronavirus-2 COVID-19 COVID-19 pandemic demonstrated detect detection diminished Emergency use extreme Flow flow rates horseradish peroxidase Human intensity Laboratory Lateral flow test Lateral flow tests membrane nucleic acid paper-based assay peroxidase point of care Rapid replacing reporter respiratory SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antibody test SARS-CoV-2 antigen SARS-CoV-2 antigens sensitivity serological test Serological tests serology seroprevalence survey serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 signal intensity supply chains US FDA vertical vertical flow. were used [DOI] 10.1021/acssensors.1c00235 PMC 바로가기 [Article Type] Article
A data driven change-point epidemic model for assessing the impact of large gathering and subsequent movement control order on COVID-19 spread in Malaysia말레이시아의 COVID-19 확산에 대한 대규모 집회 및 후속 이동 통제 명령의 영향을 평가하기 위한 데이터 기반 변경점 전염병 모델Research Article Published on 2021-05-272022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, [키워드] Analysis Asymptomatic Bayesian framework capture class contributed Control country COVID-19 COVID-19 case COVID-19 cases develop disease disease spread effective Effectiveness Epidemic Government heterogeneous implementation Inference Intervention introduced Local Malaysia mathematical Mathematical models methodology Ministry of Health movement NPI NPIs provided Quantitative quantitative assessment reached reduce reported second wave SEIR Spread spread of COVID-19 starting statistical analysis subsequent the disease Transmission transmission rate transmission rates variant [DOI] 10.1371/journal.pone.0252136 PMC 바로가기 [Article Type] Research Article
DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist스파이크 당단백질의 DC/L-SIGN 인식은 SARS-CoV-2 트랜스 감염을 촉진하고 글리코미메틱 길항제에 의해 억제될 수 있습니다Research Article Published on 2021-05-202022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 바이오마커, [키워드] ACE2 antigen-presenting cells authentic SARS-CoV-2 virus capture Cell cell lines cell surface CLR CLRs Concentration COVID-19 pathogenesis DC-SIGN defined described dissemination Effectiveness ENhance entry receptor envelope protein evaluated event examined Factor Final glycan glycosylation Host identify immune cells immunomodulation IMPROVE Infection inhibited innate immune response Interaction involved L-SIGN Langerin lung tissue mechanism molecular monocyte Monocytes mucosa opens pandemic Pathogens promote Protein pseudovirus receptor receptors recognize respiratory respiratory mucosa SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike protein SARS-CoV-2 virus SIGN spike spike glycoprotein Spike protein Spread T-lymphocytes target cell target cells tested the cell the SARS-CoV-2 These data trans transfer transmission rate unique Vero E6 VERO E6 cells Viral viral infection viral spike protein virus viruses while [DOI] 10.1371/journal.ppat.1009576 PMC 바로가기 [Article Type] Research Article