Nebulized CLODOS Technology Shows Clear Virucidal Properties against the Human Coronavirus HCoV-229E at Non-Cytotoxic DosesCommunication Published on 2021-03-232022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Concentration condition Contact contaminated surfaces coronavirus coronavirus SARS-CoV-2 doses feasible for disinfection HCoV-229E human coronavirus nebulization Pathogens property SARS-CoV-2 show technology tested Transmission virucidal virus [DOI] 10.3390/v13030531 PMC 바로가기 [Article Type] Communication
Ligand-based approach for predicting drug targets and for virtual screening against COVID-19약물 표적 예측 및 COVID-19에 대한 가상 스크리닝을 위한 리간드 기반 접근 방식Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted applied approach Betacoronavirus binding pocket caused charge complementary Compound compounds conformation coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 D3Similarity database deficiency demonstrated docking drug Drug discovery drug target Efficiency False negative false negative results Feline infectious peritonitis free of charge HCoV HCoV-229E HCoV-EMC human betacoronavirus human CoV human CoV 229E information inherent lack mechanism MERS Middle East Middle East respiratory syndrome Coronavirus molecular performed platform Protein protein structure Proteins reliability reported respiratory syndrome coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus similarity structures submitted target target prediction target protein target proteins two-dimensional Virtual screening virus [DOI] 10.1093/bib/bbaa422 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafishMethods & Techniques Published on 2021-03-152022-10-27 Journal: Biology open [Category] COVID-19, [키워드] Analysis Ang II Angiotensin II Apelin blood pressure cause Cell cell type cleaving common cold coronavirus Comorbidity component components conducted Conserved synteny contribute coronavirus coronavirus SARS-CoV-2 COVID-19 Danio Danio rerio degrade diabetes disease Effects Enterocyte enzyme exacerbated expressed expressing expression expression patterns Genes Genome duplication genomic HCoV-229E help hypertension identify Infection intestinal cell investigated mechanism MERS-CoV Middle East obesity ortholog outcome peptide Phylogenetic analysis produced PROTECT RAAS receptor receptors regulate respiratory respiratory inflammation Result SARS-CoV-2 SARS-CoV-2 receptor scRNA-seq Single Cell single-cell specific type subtype susceptible System the SARS-CoV-2 transcriptomes transcriptomics underlying conditions Vascular virus zebrafish [DOI] 10.1242/bio.058172 PMC 바로가기 [Article Type] Methods & Techniques
The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafishMethods & Techniques Published on 2021-03-152022-10-27 Journal: Biology open [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] Analysis Ang II Angiotensin II Apelin blood pressure cause Cell cell type cleaving common cold coronavirus Comorbidity component components conducted Conserved synteny contribute coronavirus coronavirus SARS-CoV-2 COVID-19 Danio Danio rerio degrade diabetes disease Effects Enterocyte enzyme exacerbated expressed expressing expression expression patterns Genes Genome duplication genomic HCoV-229E help hypertension identify Infection intestinal cell investigated mechanism MERS-CoV Middle East obesity ortholog outcome peptide Phylogenetic analysis produced PROTECT RAAS receptor receptors regulate respiratory respiratory inflammation Result SARS-CoV-2 SARS-CoV-2 receptor scRNA-seq Single Cell single-cell specific type subtype susceptible System the SARS-CoV-2 transcriptomes transcriptomics underlying conditions Vascular virus zebrafish [DOI] 10.1242/bio.058172 PMC 바로가기 [Article Type] Methods & Techniques
Sero-epidemiology of human coronaviruses in three rural communities in GhanaResearch Published on 2021-03-082022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, [키워드] 229E acute respiratory syndrome ARI association baseline Blood Group collected Community conducted Coronavirus-2 cross-sectional death enrolled Epidemiological study etiology Evidence Ghana HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs highest human coronavirus human coronaviruses illness immunofluorescence assay immunofluorescent assay Infection MOST much higher NL63 no statistical difference OC43 Occurrence outbreak positive prevalent proportion recruited subjects respiratory tract infection respiratory virus responsible Result SARS-CoV-2 serum sample subject tested virus viruses [DOI] 10.11604/pamj.2021.38.244.26110 PMC 바로가기 [Article Type] Research
Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system1차 인간 기도 시스템에서 합성 STING 효능제에 의한 코로나바이러스 감염 억제Article Published on 2021-03-012022-09-11 Journal: Antiviral Research [Category] SARS, 유전자 메커니즘, 치료제, [키워드] 229E Activation addition agonists Air-liquid interface airway anti-coronavirus activity antiviral activity apical surface approved autophagy caused cell culture systems clinically common cold coronavirus Coronavirus infection Coronavirus infections COVID-19 cultures Defense defense mechanisms demonstrated dependent on diABZI. dimeric effective elicit epithelial fibroblast HCoV HCoV-229E highly pathogenic Host host defense human coronavirus human coronavirus 229E human coronaviruses Infection inhibition inhibitory effect initiated interferon interferon pathway International investigated low-dose lung cell mechanism Medicine microbial microbial infections other coronavirus other coronaviruses outbreak Pathogens pathway Pneumonia Prevent prevented primary human airway public health emergency receptor reduced Remdesivir responses SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2 virus small molecule Spread stimulator STING STING agonist the interferon the SARS-CoV-2 therapeutic potential treat Treatment triggered type I interferon unmet need Viral load [DOI] 10.1016/j.antiviral.2021.105015 PMC 바로가기 [Article Type] Article
The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptorCoronaviruses Published on 2021-02-272022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] ACE2 ACE2-expressing cell addition antagonized antiviral activity appear bind binding bovine Cell culture cell entry Coronavirus disease 2019 COVID-19 drug candidate effective experiment HCoV-229E HCoV-NL63 HCoV-OC43 heparan sulfate heparin host cell human coronavirus in vitro infect Interaction lack lactoferrin local concentration mechanism of action N-terminal pandemic plasma membrane Proteoglycan recent Remdesivir SARS-CoV-2 SARS-CoV-2 cell shown subsequent synergistic therapeutic interventions therapy viral replication viral spike protein [DOI] 10.1080/22221751.2021.1888660 PMC 바로가기 [Article Type] Coronaviruses
Transcriptomic profiling and genomic mutational analysis of Human coronavirus (HCoV)-229E -infected human cellsResearch Article Published on 2021-02-252022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Analysis antiviral response APOBEC APOBEC3B Apolipoprotein B applied BRCA1 catalytic caused Cell cellular change cholesterol chromosomal circulating common cold coronavirus Coronaviruses country CoV CoVs Critical cyclins Cytidine deaminase DNA damage downregulated downregulation elicited ENhance enzyme favor genomic Genomic analysis HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 high mortality rate host response Human human cell illness Infection information Innate immunity interferon-stimulated gene ISGs key factor marker MERS-CoV Middle East Mild MOST mRNA Mutation next generation sequencing pandemic Replication S phase SARS-CoV SARS-CoV-2 severe respiratory infection signaling pathways subunit syndrome transcript transcriptomic transcriptomic method upregulation viral infection was used [DOI] 10.1371/journal.pone.0247128 PMC 바로가기 [Article Type] Research Article
Resveratrol Inhibits HCoV-229E and SARS-CoV-2 Coronavirus Replication In VitroArticle Published on 2021-02-232022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 50% effective concentration acute respiratory syndrome antiviral response China Chloroquine Compound Concentration coronavirus cytotoxicity demonstrated drug Drug discovery drugs EC50 HCoV-229E less Novel coronavirus outbreak Rapamycin reduce reduced reduction Replication resveratrol SARS-CoV-2 Seven tested Treatment viral inhibition viral titer [DOI] 10.3390/v13020354 PMC 바로가기 [Article Type] Article
Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL EpitopesArticle Published on 2021-02-212022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] Algorithm Antigen antigen design conserved conserved epitopes coronavirus Coverage COVID-19 CTL cytotoxic T lymphocyte effective Efficacy epitope expected Genetic HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 human coronavirus induce MERS-CoV multiple coronaviruses outbreak pan-vaccine pandemic public health reported response Safe SARS-CoV SARS-CoV-2 sequence Spread Vaccine [DOI] 10.3390/v13020333 PMC 바로가기 [Article Type] Article