Declining Mortality Rate of Hospitalised Patients in the Second Wave of the COVID-19 Epidemics in Italy: Risk Factors and the Age-Specific PatternsArticle Published on 2021-09-172022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Affect age Care Characteristics Cluster collected competing COVID-19 cumulative death demographics determine disease evaluated Factor first and second wave of epidemics flow diagram highest hospitalised hospitalised patient Hospitalised patients In-hospital death in-hospital mortality in-hospital mortality rate incidence individual Italy Laboratory mortality rate multivariable analyses occurred outcome Patient pattern Progress Rate reduced reduction risk risk of death second second wave therapy vaccination Wave [DOI] 10.3390/life11090979 PMC 바로가기 [Article Type] Article
New-onset IgG autoantibodies in hospitalized patients with COVID-19COVID-19로 입원한 환자에서 새로 발병한 IgG 자가항체Multicenter Study Published on 2021-09-142022-09-12 Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] anti-cytokine anti-viral antibody anti-viral antibody response anti-viral antibody responses antibodies autoantibodies autoantibody autoantigen Autoantigens Autoimmune Autoimmunity cause clinical manifestations Connective tissue diseases coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines de novo develop disorder feature healthy controls hospitalised patient Hospitalised patients hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient IgG IgG antibodies IgG antibody immune response immune responses Influenza less magnitude myositis non-structural proteins overlap pathogenic viruses Patient positively correlated proportion Protein recognizing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV2 seasonal coronavirus seasonal coronaviruses serum structural protein structural proteins subset Systemic sclerosis viral infection with COVID-19 [DOI] 10.1038/s41467-021-25509-3 PMC 바로가기 [Article Type] Multicenter Study
Informing antimicrobial management in the context of COVID-19: understanding the longitudinal dynamics of C-reactive protein and procalcitoninResearch Article Published on 2021-09-082022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] Antimicrobial stewardship Bacterial bacterial co-infection Biomarker Biomarkers C-reactive protein C-reactive protein (CRP Clinical decision-support Co-infection Cohort Concentration COVID-19 COVID-19 patient CRP Culture cultures dataset death died Factor failure growth hospital Hospital admission hospitalised hospitalised patient Informing longitudinal management outcome Pairwise comparison Patient patients with COVID-19 PCT performed positive procalcitonin reduce Result risk risk stratification significantly higher statistically significant supplementary material Support symptom onset those who survived trajectory understanding with COVID-19 [DOI] 10.1186/s12879-021-06621-7 PMC 바로가기 [Article Type] Research Article
Diarrhoea and preadmission antibiotic exposure in COVID-19: a retrospective cohort study of 1153 hospitalised patientsEpidemiology Published on 2021-09-062022-10-28 Journal: BMJ open gastroenterology [Category] COVID-19, SARS, [키워드] 95% CI absence age antibiotic Antibiotic therapy antibiotic use Antibiotics association Blood Cohort Community confounders Course COVID-19 Dementia demographics determine diarrhoea hospitalisation hospitalised hospitalised patient increased mortality increased risk individual less London Mortality mortality risk NHS objective Patient patients with COVID-19 patients’ medical history physiological reported residual confounding Result retrospective cohort study risk South stratified time Trust was used with COVID-19 [DOI] 10.1136/bmjgast-2020-000593 PMC 바로가기 [Article Type] Epidemiology
Nurses’ perspectives of taking care of patients with Coronavirus disease 2019: A phenomenological studyResearch Article Published on 2021-09-032022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] analysed Care Coronavirus disease 2019 COVID-19 disease distress doffing donning example Factors Guilty feeling health worker hospitalised patient mechanism mechanisms National Nurse Nurses pandemic participated Patient patients Personal protective equipment Perspective physical PPE PROTECT Psychological distress rejection reported Satisfaction Support with COVID-19 [DOI] 10.1371/journal.pone.0257064 PMC 바로가기 [Article Type] Research Article
Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trialRandomized Controlled Trial Published on 2021-09-012022-10-05 Journal: The Lancet. Respiratory Medicine [Category] Coronavirus, SARS, 임상, [키워드] 1:1 95% CI adverse event adverse events alveolar Analysis assigned baseline block size cardiovascular disease center clinical benefit Clinical data clinical trial complication of COVID-19 concomitant treatment diabetes did not reduce died dose double-blind Effect Efficacy and safety eligible EU Clinical Trial EudraCT European foundation greater hazard ratio heart failure hospital hospitalised patient hypoxaemic respiratory failure Imatinib inhibitor initiative Invasive mechanical ventilation IQR Loading dose maintain malignancy management mechanical ventilation median median age medication Medicine modified intention-to-treat Mortality Netherlands not significantly different obesity oedema outcome Patient patients patients with COVID-19 peripheral oxygen saturation Placebo placebo-controlled platform Primary outcome pulmonary disease randomised Randomly receive receiving Registered required requiring supplemental oxygen RT-PCR test SARS-CoV-2 screened secondary Sex stratified supplemental oxygen survival the placebo group time Treatment two group union Ventilation was done were excluded with COVID-19 [DOI] 10.1016/S2213-2600(21)00237-X PMC 바로가기 [Article Type] Randomized Controlled Trial
LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UKConference abstract Published on 2021-09-012022-10-05 Journal: Annals of oncology : official journal of the Europ [Category] 유전자 메커니즘, [키워드] Cancer clinical COVID-19 hospitalised patient Prospective respiratory WHO [DOI] 10.1016/j.annonc.2021.08.2141 [Article Type] Conference abstract
Loss-of-function mutations in IFNAR2 in COVID-19 severe infection susceptibilityCOVID-19 중증 감염 감수성에서 IFNAR2의 기능 상실 돌연변이Article Published on 2021-09-012022-09-11 Journal: Journal of global antimicrobial resistance [Category] SARS, 변종, 유전자 메커니즘, [키워드] allelic Analysis carrier carriers categories category coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cohort COVID-19 Host Genetics Initiative COVID-19 infection enrichment Frequency Genes hospitalised patient Hospitalised patients host genetics IFN IFN pathway IFNAR IFNAR2 Immunity initiative involved LOF loss-of-function loss-of-function mutation MAF missense variant Mutation nonsynonymous variants oxygen Patient performed phase 3 study rare variant Rare variants receiving recent Regulation reported Sequencing Severe COVID-19 Infection Severe infection supplemental oxygen support susceptibility Therapeutics type I type III interferon variant Viral genetics Viral resistance whole-genome sequencing [DOI] 10.1016/j.jgar.2021.06.005 PMC 바로가기 [Article Type] Article
Clinical Characteristics of Confirmed Cases of COVID-19 Admitted at Al Nahdha Hospital, Oman: A Cross-Sectional Descriptive StudyInternal Medicine Published on 2021-08-212022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress Admission age Analysis antivirals Characteristics clinical Clinical characteristics Clinical outcome Cohort common Confirmed confirmed case confirmed COVID-19 case Coronavirus disease 2019 COVID-19 COVID-19 patients Critical care cross-sectional death described diabete Diagnosis died disease severity dry cough Factor ferritin level Fever health information hospitalised hospitalised patient Hospitalised patients hypertension IBM infiltration information International Laboratory majority male management guideline nine Older Oman patients provided public health emergency radiological required Result retrieved several characteristics severity Shortness of breath Significant significantly higher Sociodemographic SPSS Statistics steroid Steroids study population Symptom the disease the mean Treatment utilised Variation was recorded with COVID-19 [DOI] 10.7759/cureus.17343 PMC 바로가기 [Article Type] Internal Medicine
Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional studyResearch Paper Published on 2021-08-122022-10-31 Journal: EClinicalMedicine [Category] COVID-19, [키워드] antibody antiphospholipid antibody appeal case sery clinical impact Clinical research Control control group controls correlated Council COVID-19 creatinine cross-sectional d -dimer drug European evaluated finding foundation funding Government GPI group hospitalised hospitalised patient IgA IgG IgM management Moorfield MRC neurological manifestation NIHR nine Oxygen requirement pathogenicity Patient persistence Prevalence recruited reported required Scholar scientist significantly higher square state supported Swedish titre UCL USA Venous Thromboembolism Wellcome Trust with COVID-19 [DOI] 10.1016/j.eclinm.2021.101070 PMC 바로가기 [Article Type] Research Paper