intranasal – Page 9 – Communicable Diseases Research

Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients

Randomized Controlled Trial

Published on 2022-02-142022-10-04
Journal: Trials [Category] COVID19(2023년), SARS, 임상,

Lung directed antibody gene transfer confers protection against SARS-CoV-2 infection

Respiratory Infection

Published on 2022-02-132022-10-28
Journal: Thorax [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS,

[키워드] age anti-SARS-CoV-2 antibody antiviral drug approach condition COVID-19 COVID-19 pandemic dose effective effort ENhance evaluate Express expressing expression human ACE2 hypothesised immune response Immune status in vivo individuals Infection intranasal joint Laboratory Lentiviral vector Lower respiratory tract mAb mAbs mice monoclonal antibody offer passive immunity Population Prevent Protein pseudotyped raise reagent reduced respiratory infection respond SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines significantly spike sustained transfer translated Vaccine Vaccines vector VIP viral infection
[DOI] 10.1136/thoraxjnl-2021-217650 PMC 바로가기 [Article Type] Respiratory Infection

Olfactory dysfunction as a post-infectious symptom of SARS-CoV-2 infection

Review

Published on 2022-02-112022-10-28
Journal: Annals of Medicine and Surgery [Category] COVID-19,

[키워드] addition affecting Anosmia COVID-19 COVID-19 patients Diagnosis disease dry cough dysfunction epidemiological Evidence Fever headache Hypothesis impairment infected with SARS-CoV-2 Inflammation Inflammatory response initial inoculated intranasal less life-threatening Loss Loss of Smell mice nasal nasal mucosa occur olfactory olfactory dysfunction olfactory neuroepithelium Other other COVID-19 symptoms parainfluenza Pathognomonic symptom pathological mechanism pathophysiology Patient patients with COVID-19 reduced required Research resulting rhinovirus SARS-CoV-2 SARS-COV-2 infection Shortness of breath significantly Smell loss Symptom syndrome Taste loss Treatment unique virus virus infection
[DOI] 10.1016/j.amsu.2022.103352 PMC 바로가기 [Article Type] Review

Impact of Refutational Two-Sided Messages on Attitudes Toward Novel Vaccines Against Emerging Infectious Diseases During the COVID-19 Pandemic

Randomized Controlled Trial

Published on 2022-02-112022-10-04
Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 임상,

Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques

히말라야 원숭이에서 SARS-CoV-2 감염 후 면역 및 질병 매개변수에 대한 에어로졸 전달 BCG 백신의 영향

Immunology

Published on 2022-02-092022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제,

[키워드] Activation acute respiratory syndrome adaptive aerosol Aerosol BCG vaccination antibody Antibody-mediated immunity antiviral immune response applied bacille Calmette-Guérin BAL BCG BCG vaccination Bronchoalveolar lavage cell-mediated immune response cellular challenge chemokine Classical CD14+ monocyte Classical CD14+ monocytes clearance collected comparable Concentration contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 disease severity cross-protection cross-protective cross-reactive cytokine disease disease pathology disease severity early disease ENhance exceeded groups Heterologous High dose Histopathology Humoral immunity hypothesised immune cells immune mechanism immune response immune responses immune signature Immunity immunological parameters indicated induce Infection influence initial innate immune innate immune cell Innate immune cells Innate immunity Intervention intrabronchial intranasal macaque macaques marker mechanism Monocytes nasal nasal and pharyngeal swabs natural infection non-specific Occurrence parameter pharyngeal populations primary site priming quantified reduce respiratory respiratory pathogen rhesus macaque rhesus macaques SARS-CoV-2 secretion severe acute respiratory syndrome Coronavirus subsequent susceptible swabs T-cell T-cells the disease tissue tissue sample titre titres trained immunity Tuberculosis tuberculosis vaccine Vaccine Viral Viral RNA virus
[DOI] 10.3389/fimmu.2021.801799 PMC 바로가기 [Article Type] Immunology

A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease

Article

Published on 2022-02-062022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS,

Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling

SARS-CoV-2 감염으로 인한 폐 손상 모델로서의 시리아 햄스터: 병리학, 생리학 및 상세한 분자 프로파일링

Article

Published on 2022-02-012022-09-12
Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] Acute inflammation acute lung injury acute respiratory distress acute respiratory syndrome acute SARS-CoV-2 infection Analysis animal model Apoptosis ARDS caused characterized clearance coronavirus coronavirus disease COVID-19 demonstrated driving evaluate Evidence exhibited feature Ferroptosis hamster histologic host response Hypoxemia indicated infected with SARS-CoV-2 Infection inflammatory mediator intranasal lack lung Lung injury molecular molecular mechanism pulmonary permeability RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 significant difference syndrome Syrian Golden hamsters systemic illness upregulation Viral pneumonia virus
[DOI] 10.1016/j.trsl.2021.10.007 PMC 바로가기 [Article Type] Article

Cytotoxic T-Cell-Based Vaccine against SARS-CoV-2: A Hybrid Immunoinformatic Approach

Article

Published on 2022-01-302022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] 3D structure acquired immunity administration Antigen Antigen presentation binding Cancer immunotherapy canonical cellular cellular immunity characterized Coverage COVID-19 convalescent patient cytotoxic cytotoxic T lymphocytes dendritic cells epithelia epitope Epitopes highest HLA HLA class I hybrid IEDB immune protection immune response immune stimulation immunization immunogenic immunoinformatics in silico In silico methods intranasal long term immunity molecular docking Molecular docking study NetMHCpan non-allergenic non-toxic parameter peptide platform Population positive Probability protein folding provide provided robust SARS-CoV-2 T-Cell vaccine screened stimulate Structure synthetic long peptide T-cells Toll-like receptor Toxicity vaccination VaxiJen 2.0 Viral mutations virus clearance
[DOI] 10.3390/vaccines10020218 PMC 바로가기 [Article Type] Article

Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates

Article

Published on 2022-01-212022-10-04
Journal: NPJ Vaccines [Category] 변종,

Induction of Innate Immune Response by TLR3 Agonist Protects Mice against SARS-CoV-2 Infection

Article

Published on 2022-01-192022-10-28
Journal: Viruses [Category] COVID-19,