Detection of Antibodies Against the SARS-CoV-2 Spike Protein and Analysis of the Peripheral Blood Mononuclear Cell Transcriptomic Profile, 15 Years After Recovery From SARSSARS-CoV-2 스파이크 단백질에 대한 항체 검출 및 SARS 회복 15년 후의 말초혈액 단핵세포 전사체 프로파일 분석Cellular and Infection Microbiology Published on 2021-11-182022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Against antibodies antibody binding cellular entry cellular immunity chemiluminescence chemokine clinical manifestations collected conducted convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity cytokine detection elicit epitope Epitopes exhibited expressed Genes heatmap homology immune immune cross-reactivity Immune status Immunity immunoassay in vitro inhibit interferon gamma microsphere mononuclear cell mRNA mRNAs pandemic patients with COVID-19 patients with SARS PBMC PBMCs peptide peptide epitope peripheral Peripheral blood Peripheral blood mononuclear cells Post-infection profile protein sequences Research respiratory responses SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein serum serum antibodies severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signal transduction significantly spike Spike protein stimulated the SARS-CoV-2 transcriptomic profile was obtained were used Year [DOI] 10.3389/fcimb.2021.768993 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견Case Study Published on 2021-11-172022-09-01 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome [DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study
Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral MechanismsCurcumin은 다중 항바이러스 메커니즘을 통해 Vero E6 세포의 시험관 내 SARS-CoV-2 감염을 억제합니다Article Published on 2021-11-162022-09-10 Journal: Molecules [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] addition Affect anti-inflammatory effect anti-inflammatory property Antiviral antiviral activity Antiviral effect COVID-19 Curcumin Cytokines cytotoxicity D614G D614G strain delta variant ELISA evaluated exhibit exhibited IL-1β IL-6 IL-8 immune response in vitro independent Infection Inflammation inhibited investigated mononuclear cell mononuclear cells MTT Multiple PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Plaque assay Post-infection pro-inflammatory cytokine pro-inflammatory cytokines qPCR quantified released replicative required SARS-CoV-2 SARS-COV-2 infection scarcity the SARS-CoV-2 Therapeutic approach therapeutic approaches to define Treatment treatment strategy triggered Vero E6 VERO E6 cells Viral viral titer virucidal were used [DOI] 10.3390/molecules26226900 PMC 바로가기 [Article Type] Article
Single-Cell RNAseq Profiling of Human γδ T Lymphocytes in Virus-Related Cancers and COVID-19 DiseaseArticle Published on 2021-11-032022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] acute COVID-19 Blood cancer patient Cell children coronavirus disease COVID-19 COVID-19 disease differentiation disease gammadelta healthy Human increase Inflammatory lung lesion lung tissue lymphocyte lymphoma memory mononuclear cell Patient patients Patients with cancer patients with COVID-19 PBMC pediatric Pediatric patient Peripheral blood Profiling promote recruitment RNAseq robust scRNAseq severe COVID-19 disease Single Cell single-cell subset syndrome T cell T cell activation T cell lymphopenia T lymphocyte T lymphocytes therapy tissue trajectory Transcriptome transcriptomic Tumor tumors [DOI] 10.3390/v13112212 PMC 바로가기 [Article Type] Article
Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infectionResearch article Published on 2021-11-012022-10-05 Journal: Computers in biology and medicine [Category] SARS, 바이오마커, 변종, [키워드] activities acute respiratory syndrome ADORA3 analysed Analysis Bacille calmette guerin (BCG) BCG BCG vaccination caused CCL4 CCR2 CD33 Comorbidity condition contagious coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID‐19 Critical CXCL1 CXCL8 cytokine DEGs differentially expressed gene Differentially expressed genes driving drug candidate Drug molecules Effect elements enrichment analysis expression expression pattern finding functional Functional enrichment analysis Gene ontology Genes Genetic IFNg IL-17 Infection Interaction investigated ITGB2 miRNA molecular mononuclear cell more difficult Mortality network analysis Novel coronavirus pandemic pathway Pathways PBMC Peripheral blood PPI PTGS2 Regulatory Research SARS-CoV-2 SARS-COV-2 infection severity significantly Spread TFS therapeutic TLR5 transcriptomic vaccination Vaccine virus spread [DOI] 10.1016/j.compbiomed.2021.104891 [Article Type] Research article
Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patientsMulti-omic 접근법은 COVID-19 암 환자의 혈액에서 증식에 대한 타고난 면역 반응을 결합하는 전사 네트워크를 식별합니다.Article Published on 2021-10-292022-09-12 Journal: Cell Death & Disease [Category] MERS, 임상, 진단, [키워드] Alter alteration analyses Analysis analyzed approach Blood Cancer cancer patient Cancer patients cancer type CD4 CD8 Cell cell population central memory circulating clinical co-morbidities Cohort conducted contribute controls COVID-19 COVID-19 disease COVID-19 patient cytokine Cytometry Diseases Donor eight elevated enrichment analysis expression Gene Expression Genes highlight homeostasis identify IL-13 IL-6 IL-8 Immune cell immune function immune system immunological parameter immunology Infection Infectious diseases inflammation response innate immune response investigated IP-10 modulated mononuclear cell mortality rates multiplex natural killer outcome Patient PBMC PBMCs performed Peripheral blood plasmablast pro-inflammatory factor proliferation reduced Regulation SARS-COV-2 infection serum cytokine Signaling solid cancers Stage subpopulation T cell T lymphocyte transcriptional worsened [DOI] 10.1038/s41419-021-04299-y PMC 바로가기 [Article Type] Article
Differential dynamics of peripheral immune responses to acute SARS-CoV-2 infection in older adults Research Published on 2021-10-282022-10-05 Journal: Nature Aging [Category] SARS, 임상, [키워드] Activation acute SARS-CoV-2 infection age Analysis antigen-specific B cell correlated COVID-19 Cytokine storm cytotoxicity dendritic cell elevated exacerbated examined exhibited Factors Frequency groups individual memory B cell memory T monocyte mononuclear cell myeloid cell natural killer cell neutralizing antibody Older older patient Patient patients with COVID-19 Peripheral blood peripheral immune response phenotype plasma plasmablast provide reduced reversed RNA sequencing severe COVID-19 severe disease Signaling subset T cell lymphopenia T cell responses transcriptionally type I interferon [DOI] 10.1038/s43587-021-00127-2 [Article Type] Research
Genome-Wide Profiling Reveals Alternative Polyadenylation of Innate Immune-Related mRNA in Patients With COVID-19게놈 전체 프로파일링, COVID-19 환자에서 선천적 면역 관련 mRNA의 대체 폴리아데닐화 밝혀냄Immunology Published on 2021-10-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alternative polyadenylation alternative splicing APA APA regulator Biomarker cascade category caused Clinical treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production dataset de novo death Diseases effective event highlight human gene human genes human peripheral blood mononuclear cell Immune escape Immunity Infection Infectious diseases Innate innate immune response Innate immunity Interferon-gamma MAPK mechanism mechanisms mononuclear cell mRNA neutrophil neutrophil activation Ontology pandemic patients PBMC performed Peripheral blood Polyadenylation potential therapeutic target Profiling Regulation reported respiratory RNA RNA-seq data SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Variation Viral [DOI] 10.3389/fimmu.2021.756288 PMC 바로가기 [Article Type] Immunology
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccinesArticle Published on 2021-10-262022-10-04 Journal: Cell Discovery [Category] 바이오마커, 치료제, [키워드] alteration biological assay CD8 clinical conditions Coagulation coagulation disorders Comprehensive country COVID-19 pandemic COVID-19 patients COVID-19 vaccination diabetes Gene Expression healthy volunteer hemoglobin immune cell types immunology inactivated increase in Infection monocyte mononuclear cell mRNA Neutralizing antibodies NF-κB signaling occur pathophysiological PBMCs Peripheral blood Potassium profiles reduced renal dysfunction renal function reported responses SARS-COV-2 infection SARS-CoV-2 vaccine scRNA-seq Sequencing serum sodium Similar change Symptoms T cell transcriptomics type I interferon vaccination Vaccine with COVID-19 [DOI] 10.1038/s41421-021-00329-3 PMC 바로가기 [Article Type] Article
A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVIDArticle Published on 2021-10-262022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] accompanied Activation acute SARS-CoV-2 infection adaptive alteration Antigen presentation characterized circulating correlated corticosteroid treatment Corticosteroids Course dendritic cell distribution established therapy expression FIVE Follow-up highlight immune immune profiling Immunity immunological alterations long-COVID marker Migration Monocytes mononuclear cell naïve nine pathophysiology Patient performed phenotype populations post-COVID-19 patient Prednisone pro-inflammatory PSP regulatory T cells steroid Symptom Treatment [DOI] 10.3390/biomedicines9111540 PMC 바로가기 [Article Type] Article