Are the Follicular Fluid Characteristics of Recovered Coronavirus Disease 2019 Patients Different From Those of Vaccinated Women Approaching in vitro Fertilization?Physiology Published on 2022-02-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Ala Analysis anti SARS-CoV-2 immunoglobulins antibody carried collected Combination control group coronavirus disease Covid patients COVID-19 dismutase evaluate FIVE Follicular fluid healthy healthy controls in vitro induce inflammatory proteins interleukin-6 Lipid metabolic effect metabolite metabolomic analysis metabolomics Necrosis nine NMR NMR spectroscopy Oocyte outcome participant pilot study Pro proinflammatory markers radical scavenger recovered recovered COVID-19 patient Recovered COVID-19 patients SARS-CoV-2 SARS-COV-2 infection selected significantly lower TNF-α TNFα trimethylamine vaccination was performed western blotting analysis women [DOI] 10.3389/fphys.2022.840109 PMC 바로가기 [Article Type] Physiology
Cardiac inflammation and microvascular procoagulant changes are decreased in second wave compared to first wave deceased COVID-19 patients심장 염증 및 미세혈관 응고촉진제 변화는 1차 물결로 사망한 COVID-19 환자에 비해 2차 물결에서 감소Article Published on 2022-02-152022-09-12 Journal: International journal of cardiology [Category] COVID19(2023년), SARS, 진단, [키워드] accompanied addition analyzed Anticoagulant cardiac Cardiac pathology CD3+ CD45+ CD68+ change CML Cohort control patient COVID-19 COVID-19 patient COVID-19 patients Deceased decrease disease course DPP4 dysfunction Evidence Factor factor VII factor XII fatal COVID-19 First and second wave First wave heart infiltration Inflammation Injury leukocyte lymphocyte lymphocytic myocarditis Macrophage majority marker Microvascular thrombosis Mortality Necrosis Non-COVID-19 Occurrence pandemic patients peptidase procoagulant procoagulant factor Protein quantified reported second wave shown significant decrease significantly significantly lower T lymphocyte Thrombosis microvasculature. Treatment use of steroid [DOI] 10.1016/j.ijcard.2021.11.079 PMC 바로가기 [Article Type] Article
Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signalingResearch Paper Published on 2022-02-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] activated Activation alveolar inflammation analyzed attenuate cause caused CCL3 change chemokine collagen Coronavirus disease 2019 COVID-19 dihydroartemisinin effective expression fibrosis growth hydroxyproline IL-6 Inflammatory response inhibit inhibited inhibiting inhibitory effect JAK2 JAK2/STAT3 JAK2/STAT3 signaling janus lung Lung injury lung tissue molecular analysis molecular mechanism Necrosis phosphorylated pulmonary fibrosis pulmonary inflammation reduced representing SARS-CoV-2 serum Signaling staining STAT3 TGF-β1 therapeutic therapeutic effect TNFα treat Treatment with COVID-19 worldwide pandemic [DOI] 10.18632/aging.203874 PMC 바로가기 [Article Type] Research Paper
Response to Vaccines in Patients with Immune-Mediated Inflammatory Diseases: A Narrative ReviewReview Published on 2022-02-152022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activating acute respiratory syndrome Affect antibody appear attenuate B-cell biologic Biologic therapy coronavirus CTLA-4 described dose Efficacy evaluated fusion protein healthy individuals IL-17 IL-6 immune response immune system Immune-mediated inflammatory disease Immune-mediated inflammatory diseases immunosuppressants immunosuppressive immunosuppressive drugs impair increased risk Infection Inflammatory bowel disease inhibitor inhibitors integrin Interleukins knowledge limit Live attenuated vaccine narrative Necrosis pathogenic Patient patients patients receiving treatment patients treated protective immune response protective response recommendation reduced replicate response responses review rheumatoid arthritis risk of infection Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine severe disease Therapies therapy TNF treat Treatment vaccination Vaccine vaccine response Vaccines [DOI] 10.3390/vaccines10020297 PMC 바로가기 [Article Type] Review
Persistent Endothelial Dysfunction in Coronavirus Disease-2019 Survivors Late After RecoveryMedicine Published on 2022-02-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute phase association Atherosclerosis brachial brachial artery Concentration consequence Control controls Coronavirus disease 2019 coronavirus disease-2019 correlated COVID-19 elevated Endothelial dysfunction endothelial function flow-mediated dilation healthy control healthy controls Inflammation Inflammatory biomarker information IQR Necrosis outcomes Patient patients performed persistent Prospective reduced Result risk serum significantly lower survivor the healthy TNF-α TNF-α Vascular were assessed [DOI] 10.3389/fmed.2022.809033 PMC 바로가기 [Article Type] Medicine
Increased Circulating Cytokines Have a Role in COVID-19 Severity and Death With a More Pronounced Effect in Males: A Systematic Review and Meta-AnalysisPharmacology Published on 2022-02-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 95% confidence interval acute respiratory syndrome article Asian caused circulating claimed coronavirus Coronavirus disease 2019 COVID-19 COVID-19 severity COVID-2019 cytokine Cytokines Cytokines storm death death group demonstrated driving Effect elevated Epidemic European Evidence Factor females groups high mortality identify IL-10 IL-17 IL-1β IL-4 IL-6 IL-8 Increased increased mortality Inflammatory cytokine interleukin-6 key factor male Meta-analysis Mortality much higher Necrosis non-survivor Patient patients potential risk predisposition receptor review risk of bia role SARS-CoV-2 screened searched Serum level severity Sex Sex bias significantly the mean TNF-α upregulation Web of Science were measured [DOI] 10.3389/fphar.2022.802228 PMC 바로가기 [Article Type] Pharmacology
Targeting TNF-α for COVID-19: Recent Advanced and ControversiesPublic Health Published on 2022-02-112022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, COVID19(2023년), SARS, [키워드] ACE2 acute lung injury angiotensin-converting enzyme 2 association characterized coronavirus disease COVID-19 CRS Cytokine release syndrome Disease progression effective facilitate IL-10 IL-2 IL-7 Infection infliximab inhibitors Interaction MIS-C Necrosis pathophysiologic pathway pro-inflammatory cytokine recent SARS-CoV-2 severe COVID-19 patients severe SARS-CoV-2 Severity of disease targeting therapeutic strategy TNF-α inhibitor TNF-α Treatment Trigger upregulated [DOI] 10.3389/fpubh.2022.833967 PMC 바로가기 [Article Type] Public Health
Exploration of the Mechanism of Lianhua Qingwen in Treating Influenza Virus Pneumonia and New Coronavirus Pneumonia with the Concept of “Different Diseases with the Same Treatment” Based on Network PharmacologyResearch Article Published on 2022-02-082022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] 3CL ACE2 angiotensin-converting enzyme 2 Apoptosis binding biological process biological processes cell proliferation component components concept COX2 cytokine Cytoscape database DAVID docking docking result emodin enrichment analysis exploration FIVE IL-17 IL-6 immune system Influenza virus interleukin-6 Intervention Invasion involved KEGG Kyoto Luteolin MAPK mechanism metabolism Necrosis network New Novel coronavirus Occurrence Ontology pathway Pathway enrichment analysis Pathways Pharmacology Pneumonia protease Protein quercetin Regulation Result rutin screened Seven T cell receptor target targets TNF Toll-like receptor treating Treatment was used [DOI] 10.1155/2022/5536266 PMC 바로가기 [Article Type] Research Article
COVID-19-associated necrotizing encephalopathy presenting without active respiratory symptoms: a case report with histopathology활동성 호흡기 증상이 없는 코로나19 관련 괴사성 뇌병증: 조직병리학 증례 보고Case Reports Published on 2022-02-012022-09-11 Journal: Journal of Neurovirology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Aphasia Atypical Case report cerebrospinal fluid characteristic coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 described detect diagnosed Diagnosis diagnostic Encephalopathy etiologies exclusion expressive expressive aphasia feature hemorrhage high-dose methylprednisolone Histopathology Infection Inflammation lesion Methylprednisolone Mild MRI Necrosis neutrophilic Next-generation sequencing nucleic acids outcome pathogenic Patient perivascular pleocytosis Presence presenting respiratory symptoms SARS-CoV-2 secondary to serology severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 small vessel Symptoms treated Vasculitis viral respiratory [DOI] 10.1007/s13365-021-01042-3 PMC 바로가기 [Article Type] Case Reports
Lower Serologic Response to COVID-19 mRNA Vaccine in Patients With Inflammatory Bowel Diseases Treated With Anti-TNFα항-TNFα 치료를 받은 염증성 장 질환 환자의 코로나19 mRNA 백신에 대한 혈청학적 반응 감소Observational Study Published on 2022-02-012022-09-11 Journal: Gastroenterology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] administration adverse event adverse events AEs all subject all subjects Anti-spike anti-spike antibody anti-TNF antibody BNT162b2 booster dose comparable coronavirus disease COVID-19 dose doses drug level drug levels enrolled function functional groups HCs healthy control healthy controls high risk IBD infection rate infections Inflammatory bowel disease inflammatory bowel diseases inhibitory Lower magnitude Messenger RNA mounted mRNA mRNA-BNT162b2. multicenter Necrosis not affect Patient patients treated Pfizer Pfizer/BioNTech Prospective Prospective Study remained response Safe safety profile second dose serologic Serologic response serologic responses seronegative seropositive significantly lower stratified therapy TNFα treated treated patients Treatment Vaccine vaccine dose vaccine response vaccine responses [DOI] 10.1053/j.gastro.2021.10.029 PMC 바로가기 [Article Type] Observational Study