platelet activation – Page 9 – Communicable Diseases Research

Antibody-mediated platelet activation in COVID-19: A coincidence or a new mechanism of the dysregulated coagulation system?

COVID-19의 항체 매개 혈소판 활성화: 조절되지 않은 응고 시스템의 우연 또는 새로운 메커니즘?

Comment

Published on 2021-05-012022-09-12
Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 진단,

Computational Identification of Potential Anti-Inflammatory Natural Compounds Targeting the p38 Mitogen-Activated Protein Kinase (MAPK): Implications for COVID-19-Induced Cytokine Storm

Article

Published on 2021-04-292022-10-28
Journal: Biomolecules [Category] COVID-19, MERS,

[키워드] Activation aggregation Anti-inflammatory anti-inflammatory activity anti-inflammatory compounds Antiviral AUC AutoDock binding energy characteristic China Compound Concentration coronavirus coronavirus disease COVID-19 Critical Cytokine storm elevated elicit exhibit exhibited greater identification identify immunosuppressive in vitro Inflammation inhibitor inhibitors inhibitory kinase kinase inhibitors MAPK mitigate molecular molecular docking Molecular dynamics simulation natural natural products p38 MAPK Patient PDB ID pharmacological Platelet platelet activation Potential predicted pro-inflammatory cytokine pro-inflammatory cytokines profile receptor reported residue ROC screened storm targeting the cytokine storm therapeutic target Toxicity with COVID-19 X-ray
[DOI] 10.3390/biom11050653 PMC 바로가기 [Article Type] Article

SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism

SARS-CoV-2는 ACE2와 무관한 메커니즘을 통해 혈소판 및 거핵구와 상호작용합니다

Letter to the Editor

Published on 2021-04-292022-09-10
Journal: Journal of Hematology & Oncology [Category] MERS, SARS, 유전자 메커니즘,

Single-cell multi-omics analysis of the immune response in COVID-19

COVID-19의 면역 반응에 대한 단일 세포 다중 오믹스 분석

Article

Published on 2021-04-202022-09-10
Journal: Nature Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration alveolar alveolar macrophage Analysis Antigen antigen receptor B lymphocyte blood immune cell blood sample Blood samples C1QA cause CD16 CD34 CD8 Cell cellular component characterized circulating Cohort complement contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis cross-sectional disease disease severity effector memory effector T cell effector T cells expansion expressing follicular Haematopoiesis helper T cell hematopoietic progenitor cell highlight IgA2 Immune cell immune cells immune response individuals with COVID-19 Infection lymphocyte Macrophage megakaryopoiesis memory T cells Mild Mild disease monocyte Monocytes mononuclear cell mononuclear cells Patient performed Peripheral blood Peripheral blood mononuclear cells Plasma cells plasmablast plasmablasts Platelet platelet activation Platelets predicted proteome proteomic provide receptor reveal RNA sequencing SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease severity single-cell symptomatic disease T cell T cells therapy transcript Transcriptome Viral viral infection viral infections
[DOI] 10.1038/s41591-021-01329-2 PMC 바로가기 [Article Type] Article

Association of Neutrophil Activation, More Than Platelet Activation, With Thrombotic Complications in Coronavirus Disease 2019

2019년 코로나바이러스 질병의 혈전 합병증과 함께 혈소판 활성화 이상의 호중구 활성화 연관성

Article

Published on 2021-03-292022-09-11
Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커,

[키워드] activated activating acute respiratory syndrome age analyzed Antithrombotic Aspirin association Biomarker Biomarkers blocked Complication coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 disease severity enzyme feature healthy control help heparin hospitalized patients hypercoagulability Infection inhibiting less leukocyte leukocyte activation leukocytes low-molecular weight heparin matrix metalloproteinase matrix metalloproteinase-9 (MMP-9) NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil extracellular traps (NETs) Neutrophils normalized Patient patients with COVID-19 plasma Platelet platelet activation Platelets predict respiratory SARS-CoV-2 Severe acute respiratory syndrome significantly increased thrombosis Treatment triggered Venous Thromboembolism venous thromboembolism (VTE) VTE were measured worsening
[DOI] 10.1093/infdis/jiaa756 PMC 바로가기 [Article Type] Article

Thymidine Phosphorylase Is Increased in COVID-19 Patients in an Acuity-Dependent Manner

Medicine

Published on 2021-03-222022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] accompanied Acuity acute respiratory syndrome approved C reactive protein caused Clinical use Cohort Comorbidity coronavirus Coronavirus disease 2019 correlated COVID-19 COVID-19 diagnosis CRP D-dimer Department diabete diabetic patients drug effective Emergency evidenced expression food IFN Increased indicated Inflammation inhibitor lactate dehydrogenase LDH marker Massachusetts General Hospital mechanism organ damage Patient plasma platelet activation positive correlation positively correlated provided recent Respiratory disease respiratory symptoms SARS-CoV-2 selective targeting thrombosis thrombotic Thrombotic events thymidine thymidine phosphorylase tipiracil Treatment TYMP with COVID-19
[DOI] 10.3389/fmed.2021.653773 PMC 바로가기 [Article Type] Medicine

Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs

SARS-CoV-2에 대한 네트워크 분석 및 분자 매핑을 통해 약물 표적을 밝히고 임상적으로 개발된 약물의 용도 변경

Article

Published on 2021-03-012022-08-31
Journal: Virology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] (hydroxychloroquine) Analysis Antibiotics antimalarial antiretroviral Azithromycin BCL-2 biological process carried chemokine Chemokine receptor clinically Combination coronavirus dietary supplement dietary supplements disease networks docking docking analysis docking study drug drug combination Drug repurposing drug target effective EGFR ErbB Estrogen event FoxO global pandemic GnRH HIF-1 host inflammatory response Hydroxychloroquine IL-17 insulin Interaction involved Jak-STAT KEGG pathway analysis life cycle Lopinavir LOPINAVIR AND RITONAVIR MAPK modulation molecular molecular docking molecular mechanism morbidity and mortality mortality rate multiple pathway multiple pathways network Neurotrophin novel Novel coronavirus Ontology PARP pathway platelet activation predict PRKCB Process analysis receptor reduce Ritonavir SARS-CoV-2 SARS–CoV–2. signaling pathway STAT suggested target targets thyroid hormone TNF Toll-like receptor Treatment VEGF Viral viral infection viral infectivity viral life cycle viral replication virus Vitamin Vitamin C
[DOI] 10.1016/j.virol.2020.12.006 PMC 바로가기 [Article Type] Article

Circulating microparticles and activated platelets as novel prognostic biomarkers in COVID-19; relation to cancer

COVID-19의 새로운 예후 바이오마커로서 순환 미세입자 및 활성화된 혈소판; 암과의 관계

Research Article

Published on 2021-02-222022-09-10
Journal: PLoS ONE [Category] MERS, 바이오마커,

[키워드] accumulated accumulation activated affected AST blood sample Blood samples C-reactive protein Cancer Cancer patients Care Chain Reaction citrate Coagulopathy collected COVID COVID-19 COVID-19 affected patient COVID-19 infection creatinine determine endothelial enrolled healthy controls healthy donor healthy donors healthy individual healthy individuals healthy volunteer hematologic hemoglobin LDH malignant marker Microparticle no significant difference parameters Patient patients Platelet platelet activation Platelets polymerase chain polymerase chain reaction positive COVID-19 prognostic prognostic biomarker Prognostic biomarkers recruited Result reverse transcription reverse transcription polymerase chain reaction RT-PCR severe COVID-19 patient significantly significantly higher significantly lower sodium citrate sodium citrate solution vacutainer tube
[DOI] 10.1371/journal.pone.0246806 PMC 바로가기 [Article Type] Research Article

The COVID-19 Pandemic: Disproportionate Thrombotic Tendency and Management Recommendations

Review

Published on 2021-02-182022-10-29
Journal: Tropical Medicine and Infectious Disease [Category] COVID-19,

[키워드] accelerate addition Anticoagulant Anticoagulants anticoagulation antiplatelet Antithrombotic antithrombotic therapy Biomarker caused Coagulopathies Coagulopathy complicate COVID-19 death develop direct-acting disease disproportionate Disseminated intravascular coagulation dose Endothelial dysfunction excessive inflammation incidence increased risk individual Infectious disease Inflammation Laboratory morbidity and mortality Patient platelet activation randomized clinical trials receive receiving resulting SARS-CoV-2 severe COVID-19 severity of COVID-19 spread of COVID-19 supportive care susceptible tendency therapeutic anticoagulation therapeutic intervention therapy Thromboembolic event thrombosis thrombotic Travel Treatment virus while with COVID-19
[DOI] 10.3390/tropicalmed6010026 PMC 바로가기 [Article Type] Review

Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders

COVID-19 관련 지혈 장애에서 레스베라트롤의 치료 가능성

Review

Published on 2021-02-062022-09-12
Journal: Molecules [Category] 진단,

[키워드] abnormal coagulation aggregation Anti-inflammatory anti-inflammatory properties anti-thrombotic property appear circulating Coagulation coagulation cascade coagulation disorder coagulation disorders Comorbidities Comorbidity Compound condition contributing to COVID-19 COVID-19 patients Cytokines disorders Effect elevated Endothelial cell endothelial cells endotheliopathy expected Factor fruits hallmark Hemostasis Hemostatic heparin Inflammation Inflammatory cytokine Inflammatory cytokines involved LMWH low molecular weight low molecular weight heparin modulate modulating Mortality outcome outcomes parameter patient mortality plant Platelet platelet activation Platelets Potential Prevent reduce resveratrol risk factor Risk factors SARS-COV-2 infection severe COVID-19 severity shown systemic inflammatory response Therapeutic approach therapeutic strategy thrombosis thrombotic Thrombotic events Treatment treatment of COVID-19 Vascular virtue
[DOI] 10.3390/molecules26040856 PMC 바로가기 [Article Type] Review