Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species인간과 다른 종의 ACE2에 대한 박쥐 코로나바이러스 RaTG13 바이러스의 결합 및 분자적 기초Article Published on 2021-06-242022-09-11 Journal: Cell [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus animal reservoirs binding carried complex continuous surveillance coronavirus COVID-19 CoVs cross-neutralize cross-reactive antibody evaluated global pandemic hACE2 horseshoe bat Host host range Human human ACE2 induce intermediate horseshoe bat intermediate horseshoe bat. mAb mechanism molecular basis monoclonal antibody phylogenetically Prevent pseudovirus RaTG13 RBD Receptor binding Receptor binding domain reservoir residue residues respiratory SARS-CoV-2 SARS-CoV-2 RBD severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Surveillance the SARS-CoV-2 variants variants of concern virus VOCs [DOI] 10.1016/j.cell.2021.05.031 PMC 바로가기 [Article Type] Article
Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent SymptomsMicrobiology Published on 2021-06-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute COVID-19 acute respiratory syndrome acute SARS-CoV-2 infection Autoimmunity Biological Brainstem Care caused condition consequence Consequences coronavirus coronavirus disease Course COVID COVID-19 Diagnosis driving Factor fatigue globe Health herpesvirus Host host proteins immune cells immune dysregulation include Infection Injury Interaction Long Long COVID mechanism Microbiome molecular multiple organs pandemic PASC pathogen Patient persistent Potential required reservoir RNA virus SARS-CoV-2 Signaling subset Symptom Symptoms syndrome Therapeutic approach tissues Vagus virus [DOI] 10.3389/fmicb.2021.698169 PMC 바로가기 [Article Type] Microbiology
Metagenomic analysis of fecal and tissue samples from 18 endemic bat species in Switzerland revealed a diverse virus composition including potentially zoonotic virusesResearch Article Published on 2021-06-162022-10-28 Journal: PLoS ONE [Category] COVID-19, Fulltext, 조류인플루엔자, [키워드] Analysis bat characterized Complete contig coronavirus Coronaviruses Cross-species transmission disease effective Endemic etiology fecal Fecal sample Genome Human infect MERS-CoV metagenomic analysis Middle East MOST Non-invasive outbreak PCR reservoir risk rotavirus sequence Sequencing Stool Support Surveillance Switzerland tissue tissue sample transmissions variety vertebrates Vespertilio virus viruses zoonoses zoonotic [DOI] 10.1371/journal.pone.0252534 PMC 바로가기 [Article Type] Research Article
Mitochondrial DNA Heteroplasmy as an Informational Reservoir Dynamically Linked to Metabolic and Immunological Processes Associated with COVID-19 Neurological DisordersReview Paper Published on 2021-06-122022-10-31 Journal: Cellular and molecular neurobiology [Category] COVID-19, MERS, [키워드] activated acute respiratory syndrome adaptive antigen-presenting dendritic cell Biomarker cell type cells Central nervous system changes in CNS co-expression competent coronavirus coronavirus disease COVID-19 demonstrated dependent on distribution Evidence expression functional consequence Gene Expression genomes gut microbiome Heteroplasmy homeostasis immune immune response immunological in healthy individual Infection macrophages metabolic microglial cell mitochondrial mitochondrial DNA Mitochondrial function mitochondrial metabolism Monocytes myeloid Neurological disorders nuclear DNA organized polymorphism progression regulated reservoir SARS-CoV-2 severity signaling pathway somatic mutation undergo Variation wild type with COVID-19 [DOI] 10.1007/s10571-021-01117-z PMC 바로가기 [Article Type] Review Paper
SARS-CoV-2: An Overview of Virus Genetics, Transmission, and ImmunopathogenesisReview Published on 2021-06-102022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] addition Analysis approach bat caused cellular receptors coronavirus country CoV COVID-19 CoVs cross Cross-species transmission demonstrated Disease progression Evolution genetics Genome Host hosts human coronavirus Immune cell immune response Intervention likelihood new virus outbreak pandemic pathogenicity persistence Point mutation Recombination reduce reported reservoir RNA viruses SARS-CoV SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection similarity spike gene Spike protein Spread the SARS-CoV-2 virus virus isolate virus transmission Wuhan, China [DOI] 10.3390/ijerph18126312 PMC 바로가기 [Article Type] Review
SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolinORF8이 결여된 SARS-CoV-2 변종은 양식 밍크와 천산갑에서 발생했습니다Article Published on 2021-06-052022-09-11 Journal: Gene [Category] SARS, 변종, [키워드] absence biological significance changes in China circulating clinical feature Clinical features concern Coronaviruses COVID-19 Critical Denmark Effects highlight Host Human humans inactivation Infection Mutation Nonsense Nonsense mutations occur occurred ORF8 ORF8 protein pangolin phenotypic related virus related viruses reservoir reservoirs SARS-CoV-2 SARS-CoV-2 variant spike mutation spike mutations Spike protein the spike protein Transmissibility transmissible variant Transmission variant variants virus VOC-202012/01 [DOI] 10.1016/j.gene.2021.145596 PMC 바로가기 [Article Type] Article
S-Acylation of Proteins of Coronavirus and Influenza Virus: Conservation of Acylation Sites in Animal Viruses and DHHC Acyltransferases in Their Animal ReservoirsArticle Published on 2021-05-292022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 3D structure acylation Acyltransferase amino acid substitution animal caused Cluster conservation coronavirus CoV cysteine DHHC drugs E Evidence Evolution glycoprotein HA Host hosts human cells humans influenza A Influenza virus Localization M2 member Modification not affect overlapping palmitoylation pandemic preparedness Pandemics Protein provided recent Replication reservoir S-acylation SARS-CoV-2 Site specificity target vertebrates viral fitness virus viruses zoonotic origin [DOI] 10.3390/pathogens10060669 PMC 바로가기 [Article Type] Article
Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infectionResearch Article Published on 2021-05-242022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Adaptive immune response anti-inflammatory cytokine anti-inflammatory effect antiviral drug Asymptomatic Asymptomatic carriers CCL2 CCL3 chemokine clearance clinical manifestation Concomitant contribute correlated Cytokine storm disease driving effective elicited epithelia etiological agent expression feature high mortality Host humans IFN IL10 immune response gene immunological pathway Infection Infectious virus infiltration Inflammation Inflammatory responses innate immune response interferon interferon response interferons (IFNs ISG ISGs lethal disease leukocyte leukocytes lung MERS-CoV MERS-CoV infection Middle East Mild mucosa nasal nasal mucosa NF-κB post inoculation pro-inflammatory cytokine pro-inflammatory gene produced provoke Regulation reservoir Respiratory disease respiratory syndrome coronavirus respiratory tract Simultaneous stimulated syndrome tissue damage tissues transcribed Transcription transcriptional regulation triggering Type type I Type III IFN understanding upregulation Vaccines viral infection virus virus clearance while [DOI] 10.1371/journal.ppat.1009229 PMC 바로가기 [Article Type] Research Article
The evolution and future of influenza pandemic preparednessReview Article Published on 2021-05-062022-10-31 Journal: Experimental & Molecular Medicine [Category] COVID-19, [키워드] center circulating combating composed Control Coronaviruses Course detect develop distribution evaluate Evolution H1N1 pandemic H7N9 Health Human humans Infectious diseases Influenza influenza pandemic influenza strain Influenza virus information Intersection knowledge Laboratory learning measure MONITOR Novel coronavirus pandemic Pandemics prevention Research reservoir Richard risk SARS-CoV-2 strain Surveillance surveillance network the United State the WHO transfer Transmission USA Vaccine development WHO World Health Organization [DOI] 10.1038/s12276-021-00603-0 PMC 바로가기 [Article Type] Review Article
Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series체액성 면역 장애와 지속적인 SARS-CoV-2 감염이 있는 어린이 및 젊은 성인의 바이러스 변이체 증가: 연속 사례 시리즈Multicenter Study Published on 2021-05-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] accumulation Acute lymphoblastic leukemia Analysis broad spectrum Care Case report case sery Chain Reaction children evade Evidence evidence of highlight Host host immune responses Humoral immunity Immune escape immune responses Immunocompromised Immunocompromised patients Increased Infection infection control initial leukemia Lymphoblastic leukemia management Mutation mutations Patient pediatric performed persistent infection polymerase chain polymerase chain reaction positive Precaution real-time polymerase chain reaction Replication reservoir RNA routine SARS-CoV-2 Sequencing serological studies SEROLOGICAL STUDY single-stranded specimen strain subsequent Surveillance variants viability Viral viral culture viral evolution Viral transmission viral variant whole-genome sequencing [DOI] 10.1016/j.ebiom.2021.103355 PMC 바로가기 [Article Type] Multicenter Study