Time course of the sensitivity and specificity of anti-SARS-CoV-2 IgM and IgG antibodies for symptomatic COVID-19 in Japan일본의 코로나19 증상에 대한 항SARS-CoV-2 IgM 및 IgG 항체의 민감도 및 특이도의 시간 경과Article Published on 2021-02-022022-09-01 Journal: Scientific Reports [Category] MERS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 IgM Antibody test antibody tests chemiluminescent immunoassay CLIA coated with coronavirus Coronavirus infection coronavirus infection disease Course COVID-19 COVID-19 patients Cutoff cutoff value Day diagnosis of COVID-19 diagnosis of SARS-CoV-2 Diagnostic markers disease onset Diseases evaluate IgG IgG antibody IgG test IgG titers IgM IgM and IgG Infection Infectious diseases Japan less magnetic bead Magnetic beads much higher patient population Protein reported required respiratory respiratory syndrome coronavirus ROC analysis SARS-CoV-2 SARS-CoV-2 IgM SARS-COV-2 infection SARS-CoV-2 nucleocapsid sensitivity Sensitivity and specificity sera Spike protein subjects suggested symptom onset symptomatic the SARS-CoV-2 time titers Treatment [DOI] 10.1038/s41598-021-82428-5 PMC 바로가기 [Article Type] Article
Evaluating SARS-CoV-2 spike and nucleocapsid proteins as targets for antibody detection in severe and mild COVID-19 cases using a Luminex bead-based assayLuminex 비드 기반 분석을 사용하여 중증 및 경증 COVID-19 사례에서 항체 검출을 위한 표적으로 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질 평가Article Published on 2021-02-012022-09-11 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody detection Antibody test Antigen assays Bead-based assay Combination coronavirus COVID-19 case domain ELISA Evaluating FIVE IgA antibodies IgA antibody IgA response IgG IgG antibody IgM include Infection Luminex antibody test Mild mild case mild cases multiple antigen multiple antigens Multiplexing neutralization neutralization test neutralizing antibody nucleocapsid nucleocapsid protein offer Pathogens RBD RDTs Receptor-binding domain Recombinant nucleocapsid protein respiratory SARS-CoV-2 SARS-CoV-2 spike sera serological serological test Serological tests Serosurveillance severe cases significantly lower specificity Support symptom onset target threshold titers virus neutralization assays virus neutralization test Virus neutralization test. while [DOI] 10.1016/j.jviromet.2020.114025 PMC 바로가기 [Article Type] Article
SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virusSARS-CoV-2 특이적 항체 및 중화 분석은 바이러스에 대한 광범위한 체액성 면역 반응을 나타냅니다Article Published on 2021-01-292022-09-10 Journal: Communications Biology [Category] 진단, 치료기술, 치료법, [키워드] against SARS-CoV antibodies antibody Antibody Response assays blocked convalescent plasma COVID-19 COVID-19 patient detectable development Dilution donors Effectiveness Hospitalized hospitalized patients Host humoral humoral immune response IgA IgG antibodies IgG antibody IgG1 individual Infectious-disease diagnostics NAb NAbs negative controls Neutralization assay neutralization assays neutralization titer neutralization titers Neutralizing antibodies neutralizing antibody nucleocapsid protein Other Outpatient outpatients Patient Protein pseudotyped lentiviruses pseudovirus public health question response SARS CoV SARS CoV-2 SARS-CoV spike protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2 spike protein sensitivity specific IgG antibody specificity spike Spike protein subject the antibody response titers Translational research Vaccine development Vaccines virus was determined [DOI] 10.1038/s42003-021-01649-6 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severitySARS-CoV-2 감염은 질병 중증도와 상관관계가 있는 신속한 중화 항체 반응을 유발합니다Article Published on 2021-01-282022-09-01 Journal: Scientific Reports [Category] 진단, 치료제, [키워드] Adaptive immunity age Analysis analyzed antibody appearance association Asymptomatic individuals Cohort COVID-19 defined dependence Detection limit diagnosed disease severity elicit enrolled Gender Hospitalized hospitalized patients Humoral immunity identify immune mechanism immunology individual Infectious diseases Kinetics longitudinal longitudinal analysis magnitude Multiple Multiple regression Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses neutralizing response Neutralizing titer neutralizing titers non-parametric test non-parametric tests parameters participant Particles protective effect reached replicative SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection serological significantly increased symptoms onset These data titers Treatment virological tests virus were assessed were used [DOI] 10.1038/s41598-021-81862-9 PMC 바로가기 [Article Type] Article
Neutralization assay with SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virionsSARS-CoV-1 및 SARS-CoV-2 스파이크 유사형 쥐 백혈병 비리온을 사용한 중화 분석Methodology Published on 2021-01-042022-09-01 Journal: Virology Journal [Category] 진단, 치료기술, [키워드] Abbott antibody Antibody test antibody tests binding candidate vaccine capsid circumvent comparison Comparisons composed Concordance condition coronavirus COVID-19 detectable Euroimmun expressed firefly luciferase Genome IgG IgG test immunogenicity infected patient infected patients Influenza influenza infection Laboratory leukemia level 2 level 3 luciferase measure MLV murine Murine leukemia virus neutralization Neutralization assay neutralization titer neutralization titers Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing titers offer Particle Patient patients hospitalized plasma Prognostic factor promise pseudotyped Pseudotyped virus pseudovirion pseudovirions pseudovirus pseudoviruses R 2 ranged Receptor binding domain Replication replication-competent SARS-CoV-2 required Result SARS SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein serum serum sample serum samples Siemen Siemens spike spike glycoprotein tested titers Viral diseases virion virus viruses [DOI] 10.1186/s12985-020-01472-1 PMC 바로가기 [Article Type] Methodology
The kinetics of humoral response and its relationship with the disease severity in COVID-19체액 반응의 역학 및 COVID-19의 질병 중증도와의 관계Article Published on 2020-12-112022-09-10 Journal: Communications Biology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] absorbance antibody Antibody Response Antibody titer Antibody titers appearance time caused collected coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Dilution disease disease course disease severity disease severity of COVID-19 domain enrolled geometric mean geometric mean titers global pandemic humoral Humoral response IgG IgG antibodies IgM IgM and IgG Immunoglobulin infections NAb NAbs neutralizing antibody nucleocapsid patients with COVID-19 plasma plasma sample plasma samples positive correlation RBD Receptor-binding domain respiratory risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case severity severity of COVID-19 Spike protein Spike proteins Stage tested the antibody the disease the spike protein titers viral infection was measured was used were measured [DOI] 10.1038/s42003-020-01526-8 PMC 바로가기 [Article Type] Article
6-month SARS-CoV-2 antibody persistency in a Tyrolian COVID-19 cohort티롤리안 COVID-19 코호트에서 6개월 SARS-CoV-2 항체 지속성Original Article Published on 2020-12-092022-09-10 Journal: Wiener Klinische Wochenschrift [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age All participant All participants Anti-viral anti-viral antibody antibody antibody response against Antibody testing Arthritis average binding antibody caused convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cohort cut-off cut-off point decrease Diagnosis disease disease onset dropped ELISA except for Follow-up healthy Hyposmia identify Immunity immunized individuals Infection information life Neutralizing Neutralizing antibodies neutralizing antibody participant Prospective Receptor binding domain respiratory Result rheumatoid arthritis S1 subunit SARS-CoV-2 antibody severe acute respiratory syndrome Coronavirus specificity Spike protein the S1 subunit the spike protein titers virus were used [DOI] 10.1007/s00508-020-01795-7 PMC 바로가기 [Article Type] Original Article
Robust neutralizing antibodies to SARS-CoV-2 infection persist for monthsSARS-CoV-2 감염에 대한 강력한 중화 항체는 몇 달 동안 지속됩니다.Report Published on 2020-12-042022-09-12 Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike Antibody Response Antibody titers binding caused chance Cohort coronavirus COVID-19 COVID-19 case dataset detectable determine global pandemic humoral immune response Immunoglobulin Immunoglobulin G individual infected individual infected individuals Infection Longevity majority Mild mild to moderate Mild-to-moderate moderate Moderate COVID-19 Mount Sinai Mount Sinai Health System neutralization Neutralizing neutralizing antibody neutralizing antibody responses Neutralizing antibody titer neutralizing antibody titers New York City potency Reinfection remains uncertain respiratory robust robustness SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 spike protein Science screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Spike protein Symptom System the antibody response the SARS-CoV-2 titers Viral viral spike protein virus [DOI] 10.1126/science.abd7728 PMC 바로가기 [Article Type] Report
Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization회복기 혈장 항-SARS-CoV-2 스파이크 단백질 엑토도메인 및 수용체 결합 도메인 IgG는 바이러스 중화와 상관관계가 있습니다Clinical Trial Published on 2020-12-012022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 비임상, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity anti-RBD anti-receptor-binding domain anti-SARS-CoV-2 Anti-spike Asymptomatic breath Cellular immune response convalescent plasma convalescent plasma samples coronavirus COVID-19 COVID-19 disease COVID-19 treatment Critical decrease detect disease severity domain donors Dyspnea ectodomain highlight Hospitalization identify IgG IgG titer IgG titers immune immunology in vitro In vitro assay individual Infectious disease information Molecular pathology Molecular pathology. neutralization Neutralizing antibodies pathology patients with COVID-19 plasma positive correlation Probability Protective respiratory SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus significantly Spike protein surrogate titers Treatment Virus neutralization [DOI] 10.1172/JCI141206 PMC 바로가기 [Article Type] Clinical Trial
Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients회복된 COVID-19 환자의 홍역-볼거리-풍진(MMR) 역가 분석Research Article Published on 2020-11-202022-09-12 Journal: mBio [Category] 진단, [키워드] age antibody arbitrary units association Asymptomatic children close contact contact with coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation country COVID-19 COVID-19 severity COVID-19 vaccine COVID-19-related symptoms death rate death rates determine Hospitalized IgG titer illnesses immune immunization inverse correlation measles Mild symptom mild symptoms MMR MMR vaccine moderate moderate symptoms mump mumps oxygen pandemic positive recovered recovered COVID-19 patient Recovered COVID-19 patients required researcher responsible rubella SARS-CoV-2 second severe disease severity significantly subject Symptom titer titers two groups Vaccine Vaccines virus titer virus titers [DOI] 10.1128/mBio.02628-20 PMC 바로가기 [Article Type] Research Article