upstream – Page 9 – Communicable Diseases Research

Demystifying Excess Immune Response in COVID-19 to Reposition an Orphan Drug for Down-Regulation of NF-κB: A Systematic Review

NF-κB의 하향 조절을 위한 희귀 약물의 재배치를 위한 COVID-19의 과도한 면역 반응 이해: 체계적인 검토

Review

Published on 2021-02-272022-09-10
Journal: Viruses [Category] MERS, 신약개발,

Swine Acute Diarrhea Syndrome Coronavirus Nucleocapsid Protein Antagonizes Interferon- β Production via Blocking the Interaction Between TRAF3 and TBK1

Immunology

Published on 2021-02-222022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

Exit strategies: optimising feasible surveillance for detection, elimination, and ongoing prevention of COVID-19 community transmission

Research Article

Published on 2021-02-172022-10-28
Journal: BMC Medicine [Category] COVID-19, MERS,

[키워드] acute respiratory disease ARI Asymptomatic Combination Community community transmission Community transmission chains Compliance Contact Containment measure containment measures cough country COVID-19 COVID-19 case cumulative detect detectable detection effective Effectiveness Efficiency examined exit feasible Fever Follow-up generate hospital identify implementation incidence of COVID-19 Infection lifted management Mathematical modelling measure Measures median modelling Non-COVID-19 occur pooling prevention of COVID-19 primary care reduced Region reproductive Respiratory illness respiratory symptom respiratory symptoms Result Screening sensitivity supplementary material Surveillance Symptom symptomatic Syndromic fever Testing Transmission upstream
[DOI] 10.1186/s12916-021-01934-5 PMC 바로가기 [Article Type] Research Article

SARS CoV‐2 related microvascular damage and symptoms during and after COVID‐19: Consequences of capillary transit‐time changes, tissue hypoxia and inflammation

Short Review

Published on 2021-02-012022-10-28
Journal: Physiological Reports [Category] COVID-19, MERS,

[키워드] accelerate acute respiratory syndrome Affect Angiogenesis Anosmia Blood blood clot blood oxygen level Brain brain tissue breathlessness capillary dysfunction cause changes chest pain circulation Confusion consequence contribute Corona virus COVID‐19 COVID‐19 patient COVID‐19 symptom COVID‐19 Critical cytokine level delirium deteriorate diabetes diagnostic methods diffusion disease Effect elevated Endothelial cell Endotheliitis fatigue function Health heart hypertension Hypoxemia hypoxia identify Infection Inflammation instance limit long‐term symptoms Loss of Smell lung Lungs management memory Microcirculation Microvascular damage multiple organ muscle organ organs oxygen Oxygenation pericyte problem PROTECT rashes rehabilitation SARS‐CoV‐2 infection scar stimulate Symptom therapeutic tissue tissue damage tissue repair turn upstream Vascular vicious cycle virus weakness
[DOI] 10.14814/phy2.14726 PMC 바로가기 [Article Type] Short Review

Phage infection and sub-lethal antibiotic exposure mediate Enterococcus faecalis type VII secretion system dependent inhibition of bystander bacteria

파지 감염 및 준치사 항생제 노출은 Enterococcus faecalis type VII 분비 시스템 의존적 방관자 억제 억제를 매개합니다.

Research Article

Published on 2021-01-072022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] abrogate activated addition Affect antagonism antibacterial activity antibiotic Antibiotics Bacteria Bacterial bacterial cell bacterial cells Bacterial infections bacterial pathogen bacteriophage bacteriophages bacterium bystander Cell cells clinically Concentration Consensus consequence Contact Deletion Disruption DNA damage DNA damaging dose Enterococcus Evidence evidence of expression facilitate Gene Expression gram growth highlight Host Immunity independent independent of induce Infection Interaction intrinsic killing membrane microbial Microbial communities multi-drug resistant multidrug resistant pathogen phage phages positive predicted respond restrict resulting secretion Serine Staphylococcus aureus Stress stress response Stressor susceptible therapeutic therapy These data threonine Transcription transcription factor Treatment Trigger triggering triggers upstream
[DOI] 10.1371/journal.pgen.1009204 PMC 바로가기 [Article Type] Research Article

Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface

표면 성인 인간 결막, 윤부 및 각막 상피에서 SARS-CoV-2 진입 유전자의 동시 발현은 안구 표면을 통한 추가 진입 경로를 제안합니다

Article

Published on 2021-01-012022-09-10
Journal: The Ocular Surface [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] ACE2 ACE2 and TMPRSS2 expression ACE2 receptor Analysis Cell chromatin co-expression Conjunctiva conjunctival Cornea Corneal dataset embryonic ENhance epithelium expression pattern facilitate Factor fetal IFNg Immunohistochemical analysis Infection infection rate Inflammatory investigated loci molecular mechanism molecular mechanisms Multiple studies multiple study Ocular surface portal pro-inflammatory signal Propagation protease TMPRSS2 provide Result RNA SARS-CoV-2 SARS-CoV-2 entry Single Cell single-cell TMPRSS2 TMPRSS2 expression TNF transcriptional transmission route upregulation upstream Viral viral entry
[DOI] 10.1016/j.jtos.2020.05.013 PMC 바로가기 [Article Type] Article

In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients

심층 혈액 프로테옴 프로파일링 분석은 중증 코로나19 환자와 그렇지 않은 COVID-19 환자 사이에서 혈장 단백질의 뚜렷한 기능적 특성을 밝혀냈습니다.

Article

Published on 2020-12-292022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Biomarker Blood Candidates Characteristics Clinical outcome complement Complement activation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical case critical cases develop differentially expressed disease severity downstream eight Factor functional highlighting host response IMPROVE Infectious diseases interleukin interleukin-6 mortality rate Necrosis neutrophil neutrophil activation Patient patients worldwide performed plasma plasma protein Platelet potential therapeutic target potential therapeutic targets predict profiling analysis Prognosis prognostic biomarker Prognostic markers proinflammatory Protein Proteins proteome proteomic Proteomic analysis proteomics quantified reported respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity of COVID-19 Support T cell Tumor tumor necrosis tumor necrosis factor upstream
[DOI] 10.1038/s41598-020-80120-8 PMC 바로가기 [Article Type] Article

Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2

Research Article

Published on 2020-11-252022-10-28
Journal: Science Advances [Category] COVID-19, Fulltext, 신종인플루엔자,

[키워드] Ablation Activation Angiogenesis blood vessel Critical cyclin D1 dependent on developmental distress endothelial Endothelial cell endothelial repair Endothelium ENhance exacerbating Gas exchange greater H1N1 influenza impairing implicated in vivo Inflammatory response Influenza Injury Lineage lung Lung injury mechanisms Migration Mortality nuclear ovalbumin Pathogens proliferation reduced regeneration regenerative regulate repair reveal robust SARS-CoV-2 suppresse syndrome therapeutic strategy therapeutic targeting transcription factor upstream Vascular Vascular endothelium vascular homeostasis Viral pneumonia while
[DOI] 10.1126/sciadv.abc4493 PMC 바로가기 [Article Type] Research Article

Identification of Lysine Acetylation Sites on MERS-CoV Replicase pp1ab

Research

Published on 2020-11-232022-10-30
Journal: Molecular & Cellular Proteomics : MCP [Category] Coronavirus,

[키워드] acetylated acetylation Affect Analysis Bioinformatic bioinformatics conserved coronavirus disease enzyme activity event events expressing facilitate Factor Factors HDAC HEK293 cells Host host response identification immunoaffinity immunoprecipitation infected cell life-threatening mechanism MERS MERS-CoV NCBI database occur pandemic peptide peptides polyprotein post-translational modifications pp1ab predict predicted Protein regulate Regulatory replicase Replication reported responsible RNA virus sequence SIRT1 Site subject upstream viral infection Viral protein viral replication viruses was performed western blotting
[DOI] 10.1074/mcp.RA119.001897 PMC 바로가기 [Article Type] Research

The Genetic Dissection of Ace2 Expression Variation in the Heart of Murine Genetic Reference Population

Cardiovascular Medicine

Published on 2020-11-202022-10-31
Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19,

[키워드] ACE2 ACE2 receptor amplitude Analysis blood pressure BXD mice cardiac arrhythmias cardiac damage cardiovascular cardiovascular complication cardiovascular damage cell entry co-expressed co-expression correlated correlation COVID-19 COVID-19 patients cytokine diagnostic Diastolic blood pressure Dissection Electrocardiography eQTL eQTL mapping expression functional enrichment gene network gene regulaiton Genetic heart identify induce Inflammation Inflammatory involved Level locus mice morphology myocardial injury myocarditis network analysis outcome pathway Pathways Patient Population PPI Protein–protein interaction Quantitative range of variation RAS reference Regulation SARS-CoV SARS-CoV-2 virus signaling pathways significantly sinoatrial conduction strain Strains systemic inflammation TGFβ therapeutic purpose TNFα traits upstream vascular inflammation were used
[DOI] 10.3389/fcvm.2020.582949 PMC 바로가기 [Article Type] Cardiovascular Medicine