ACE2 gene – Communicable Diseases Research

Association of ACE2 Gene Variants with the Severity of COVID-19 Disease-A Prospective Observational Study

Article

Published on 2022-10-022022-11-16
Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종,

Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility

Research article

Published on 2022-10-012022-10-05
Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE2 gene ACE2 protein age angiotensin-converting enzyme 2 Arterial hypertension association Asthma BMI body mass index changes in clinical variable clinical variables COVID-19 COVID-19 susceptibility described determinant disease susceptibility DNA methylation Epigenetic epigenetics evaluate evaluated expression expression profile Factor Host host cell host factors Infection involved Male sex mechanism Methylation molecular cause mRNA expression nasopharyngeal swab sample obesity overexpression Peripheral blood promoter region quantified regulated Result risk factor RT-qPCR SARS-CoV-2 SARS-COV-2 infection Sex significant difference smoking study group susceptibility the disease type II diabete underlying disease Variability variable virus volunteers was determined
[DOI] 10.1016/j.meegid.2022.105357 [Article Type] Research article

Negative correlation between ACE2 gene expression levels and loss of taste in a cohort of COVID-19 hospitalized patients: New clues to long-term cognitive disorders

Article

Published on 2022-09-292022-11-16
Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘,

[키워드] ACE1 ACE2 ACE2 expression ACE2 gene addition Ageusia Alu Analysis Angiotensin-converting enzyme Anosmia association Brain Cell cells cognitive Cognitive dysfunction Cohort consequence correlation COVID-19 disorder Effect evaluated expression expression level Factors gene expression level Genetic genetic association Health Hospitalized hospitalized patients human cell initial symptoms long-COVID long-COVID syndrome Loss of Smell loss of taste molecular nasopharyngeal negative New obligatory occur Olfactory epithelium outcomes penetration polymorphism prevalent priming protease Quantitative quantitative trait receptor Regression model Research Respiratory system RT-qPCR SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Spread Symptom Symptoms tissue TMPRSS2 variable virus
[DOI] 10.3389/fcimb.2022.905757 PMC 바로가기

Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking

Article

Published on 2022-09-022022-11-16
Journal: Human Genomics [Category] SARS, 변종,

[키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses
[DOI] 10.1186/s40246-022-00411-1 PMC 바로가기

Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19

COVID-19로 입원한 남성의 개선된 결과와 관련된 레닌-안지오텐신 시스템 경로 치료제

Observational Study

Published on 2022-09-012022-09-11
Journal: Critical Care Medicine [Category] 유전자 메커니즘, 임상,

[키워드] ACE ACE inhibitor ACE inhibitors ACE-2 ACE2 gene acute COVID-19 acute COVID-19 illness acute respiratory syndrome acute respiratory syndrome coronavirus adjusted odds ratio Admission Analysis angiotensin Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme ARB ARBs baseline baseline characteristics cohort of patient Comorbidities component components contribute coronavirus COVID-19 COVID-19 illness d -dimer determine downregulate dysregulation Effect explain female females hospital Hospitalized hospitalized patient hospitalized patients Improved include inhibitor inhibitors Interaction less male measurement Mortality multicenter Observational cohort study organ support outcome outcomes Patient plasma polymerase chain polymerase chain reaction pro-inflammatory Prospective RAS recorded Renin renin-angiotensin system response severe acute respiratory syndrome Coronavirus Sex Sex-related differences significant effect significantly significantly higher System Therapeutics Treatment Vasopressor vasopressors Ventilation with COVID-19 X chromosome
[DOI] 10.1097/CCM.0000000000005589 PMC 바로가기 [Article Type] Observational Study

Of mice and human-specific long noncoding RNAs

마우스 및 인간 특이적 긴 비암호화 RNA

Review

Published on 2022-06-012022-09-11
Journal: Mammalian genome : official journal of the Interna [Category] COVID19(2023년), SARS, 유전자 메커니즘,

Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations

인도 인구 중 COVID-19 사례 사망률과 TMPRSS2 rs2070788 다형성의 유전적 연관성

Article

Published on 2022-03-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 바이오마커, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 gene ACE2 receptor Analysis analyzed antagonistic approach Asia Asians association Biomarker Case fatality rate causative agent CFR COVID-19 COVID-19 infection COVID-19 susceptibility disease disease susceptibility disparity East engage eQTL analysis expression Fatality rate Frequency G allele Genetic genetic association Genotype Haplotype help Host host cell increased expression India individual information intensity linkage Linkage disequilibrium lung Next-generation sequencing NGS observation pandemic pathogenicity Phylogenetic polymorphism Population populations positive predict priming risk rs2070788. S protein SARS-CoV-2 Serine serine protease severity significantly higher SNP South South Asian susceptibility tested the SARS-CoV-2 TMPRSS2 variant Variation West with COVID-19
[DOI] 10.1016/j.meegid.2022.105206 PMC 바로가기 [Article Type] Article

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects

Research article

Published on 2022-03-012022-10-05
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘,

Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic review

ACE2 및 TMPRSS2 유전자의 다형성 및 돌연변이는 코로나19와 관련이 있습니다. 체계적 검토

Review

Published on 2022-02-222022-09-11
Journal: European Journal of Medical Research [Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] abstracts ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 article bind characterized Cochrane Library coronavirus correlated COVID-19 criteria debatable determine downloaded drug duplicates eliminated English enzyme epidemic of COVID-19 evaluated Evidence expression Factor Factors Final General population Genetic genetic data genetic factors genetic susceptibility human ACE2 inclusion criteria increase in intensity item Mortality Mutation objective occurred outbreak outcomes Patient patients with COVID-19 performed polymorphism Polymorphisms PRISMA Prognosis PROSPERO receptor receptors Region Reporting respiratory Result review SARS-CoV-2 SARS-COV-2 infection searched Serine severe acute respiratory syndrome Coronavirus SNP susceptibility systematic review systematic reviews TMPRSS2 transmembrane serine protease Trial registration Type Vaccine variant Virus Disease vital role vital roles vulnerability Web of Science were excluded with COVID-19
[DOI] 10.1186/s40001-022-00647-6 PMC 바로가기 [Article Type] Review

ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men

ACE 및 ACE2 유전자 변이는 남성의 심각한 COVID-19 결과와 관련이 있습니다

Immunology

Published on 2022-02-172022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] 95%CI ACE ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted affecting age association clinical manifestation clinical manifestations Clinical manifestations of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Critical Critical illness death develop diabetes diagnosed died disease severity DNA evaluated explain Factor genetic background Genetic variant genetic variants Genomic DNA Genotype genotyped High-resolution Host hypertension IMPROVE individual insertion/deletion involved Logistic regression analysis male men Mild obesity Odds ratio outcome outcomes oxygen oxygen supplementation pandemic Peripheral blood polymorphism Polymorphisms probes respiratory respond responsible reverse transcription PCR risk factor rs2285666 RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 Sex single-nucleotide single-nucleotide polymorphism SNP study population T allele TaqMan type 2 diabetes Variability variant
[DOI] 10.3389/fimmu.2022.812940 PMC 바로가기 [Article Type] Immunology