APOEε4 Carriers Exhibit Objective Cognitive Deficits: A Cross-Sectional Study in a Single Center TrialArticle Published on 2024-03-152024-09-05 Journal: Brain Sciences [Category] update2024, [키워드] Alzheimer’s disease Apolipoprotein e Cognitive function Mild cognitive impairment plasma amyloid-β [DOI] 10.3390/brainsci14030281 PMC 바로가기 [Article Type] Article
Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer diseasearticle Published on 2023-10-312024-09-05 Journal: Fluids and Barriers of the CNS [Category] update2024, [키워드] Alzheimer disease Apolipoprotein e blood-brain barrier Human induced pluripotent cells Late-onset Alzheimer disease Neurovascular unit [DOI] 10.1186/s12987-023-00471-y PMC 바로가기 [Article Type] article
The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer’s disease spectrum, moderation and mediation role of insula network connectivityOriginal Article Published on 2023-08-142024-09-05 Journal: CNS Neuroscience & Therapeutics [Category] update2024, [키워드] Alzheimer's disease Apolipoprotein e insula network Mediation analysis moderation analysis [DOI] 10.1111/cns.14401 PMC 바로가기 [Article Type] Original Article
Apolipoprotein E in lipid metabolism and neurodegenerative diseaseArticle Published on 2023-07-182024-09-05 Journal: Trends in endocrinology and metabolism: TEM [Category] update2024, [키워드] Alzheimer’s disease Apolipoprotein e lipid metabolism Neurodegenerative disease [DOI] 10.1016/j.tem.2023.05.002 PMC 바로가기 [Article Type] Article
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patientsAPOE는 ACE2와 상호작용하여 COVID-19 환자에서 SARS-CoV-2 세포 진입 및 염증을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] ACE2 addition Affect allele ApoE APOE4 Apolipoprotein Apolipoprotein e assays binding binding affinity cardiovascular diseases carrier carriers cells cellular entry chemokine cholesterol cholesterol metabolism clinically comparable Concentration COVID-19 infection COVID-19 patient COVID-19 patients disease severity docking domain elevated explain genetic risk factor Infection Inflammation Inflammatory factor inhibit inhibiting interact Interaction isoform Lipid mechanism metabolism Protein receptor reduce Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein serum serum concentrations spike Spike protein susceptibility the SARS-CoV-2 transmission electron microscopy viral entry viruses Zinc [DOI] 10.1038/s41392-022-01118-4 PMC 바로가기 [Article Type] Article
APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical studyAPOE ε4는 심각한 CovID-19, 뇌 미세 조혈 및 침전 후 정신 피로의 위험 증가와 관련이 있습니다. 핀란드 바이오 뱅크, 부검 및 임상 연구Research Published on 2021-12-232022-09-01 Journal: Acta Neuropathologica Communications [Category] 진단, [키워드] age allele Analysis animal model animal models ApoE APOE4 APOE4 carriers Apolipoprotein e association Autopsy Biobank Brain Brain microhaemorrhage cardiovascular disease carriers clinical manifestation clinical manifestations clinical study Cohort Control COVID-19 COVID-19 case COVID-19 mortality COVID-19 sequelae datasets Evidence fatigue Finn Finnish Finns Genetic genetic association Genetic studies histopathological examination in some increased risk information initial intensive care patient intensive care patients Mental mental fatigue Neuropathology non-infected pathology perivascular post-COVID fatigue Post-viral fatigue prevalent provide provided risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Sex shown subject supplementary material susceptibility [DOI] 10.1186/s40478-021-01302-7 PMC 바로가기 [Article Type] Research
Association of Apolipoprotein e polymorphism with SARS-CoV-2 infectionSARS-CoV-2 감염과 아포지단백 e 다형성의 연관성Article Published on 2021-11-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 allele alleles Apolipoprotein Apolipoprotein e association Asymptomatic candidate gene caused Coronavirus-2 COVID-19 COVID-19 disease COVID-19 infection COVID-19 patients disease disease symptoms Epsilon General population Genetic polymorphism Genotype Host genetic factor human body Iraq morbidity and mortality pandemic PCR polymorphism required responses SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe symptoms suggested Symptoms the disease thought viral disease with COVID-19 [DOI] 10.1016/j.meegid.2021.105043 PMC 바로가기 [Article Type] Article
COVID-19 enters the expanding network of apolipoprotein E4-related pathologiesCOVID-19는 아포지단백 E4 관련 병리학의 확장 네트워크에 진입합니다.Review Published on 2021-05-012022-09-11 Journal: Redox Biology [Category] SARS, 유전자 메커니즘, [키워드] allele ApoE APOE4 Apolipoprotein e approach association Case fatality rate CFR cholesterol Cohort COVID-19 COVID-19 severity deregulation diet distribution effort elevated explain Factor Frequency Genetic genetic factors genetics Genotype Haplotype haplotypes HDL incidence individuals Infection Inflammation Lung inflammation management manifested Mortality nutrition oxidized pathology pharmacological populations potential mechanism potential mechanisms reduced SARS-CoV-2 severe COVID-19 severity SNP statins susceptibility susceptibility to infection with COVID-19 ε4/ε4. [DOI] 10.1016/j.redox.2021.101938 PMC 바로가기 [Article Type] Review
Viral Involvement in Alzheimer’s DiseaseReview Published on 2021-03-092024-09-02 Journal: ACS Chem Neurosci [Category] 대상포진, [키워드] β-amyloid Alzheimer’s disease Apolipoprotein e blood−brain barrier herpes simplex virus valacyclovir [DOI] 10.1021/acschemneuro.0c00719 PMC 바로가기 [Article Type] Review
Could COVID-19 anosmia and olfactory dysfunction trigger an increased risk of future dementia in patients with ApoE4?COVID-19 후각 기능 장애와 ApoE4 환자에서 향후 치매 위험이 증가할 수 있습니까?Article Published on 2021-02-012022-09-11 Journal: Medical Hypotheses [Category] 유전자 메커니즘, [키워드] acute illness acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alzheimer's disease Anosmia APOE4 carriers Apolipoprotein Apolipoprotein e approved association best Brain carrier Central nervous system Complication coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Dementia disease dysfunction e4 allele early stage early stages genetic risk factor Haplotype Hypothesis identify increased risk increasingly Infection involved knowledge Lewy Bodies) load mechanism Modification nasal neurodegenerative neurological Neuropsychiatric olfactory olfactory dysfunction olfactory nerve open Patient question reported respiratory risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus short duration speculation Stage subject Symptom Symptoms the strongest Therapies unique working hypothesis [DOI] 10.1016/j.mehy.2020.110479 PMC 바로가기 [Article Type] Article