bat ACE2

[키워드] ACE2 ACE2 binding ACE2 ortholog ACE2 orthologs ACE2 proteins ACE2 residue ACE2-Fc acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bat bat ACE2 bats binding binding affinity both viruses Cell cellular receptor Combination Consensus coronavirus described domain ENhance expressing FIVE hACE2 heterogeneity horseshoe bat horseshoe bats Human human ACE2 Hypothesis identify impacted inactive infect Infection Infectious virus Interaction intermediate introduced investigated Mutation neutralization neutralize neutralized Neutralizing ortholog orthologs pangolin pangolins potency Protein pseudovirus pseudoviruses RaTG13 RBD RBDs receptor receptor ACE2 Receptor-binding domain Region regions residue respiratory S-protein SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 RBD SARS-like coronavirus SARS-like viruses selection pressure severe acute respiratory syndrome Coronavirus soluble ACE2 species susceptibility the binding affinity the RBD the SARS-CoV-2 These data Variability variant Viral viral spike virus wild-type
[DOI] 10.1371/journal.ppat.1009501 PMC 바로가기 [Article Type] Research Article