Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA CloneArticle Published on 2023-03-262023-06-12 Journal: Viruses [Category] E형 간염, Fulltext, [키워드] cell culture system genotype 1 hepatitis E virus Infectious cDNA clone replication efficiency serial passages species tropism. [DOI] 10.3390/v15040845 PMC 바로가기
The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotypeArticle Published on 2022-10-072022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] animal model bronchial epithelial cell cell culture system clone clones cultures Delta epithelial ferret hamsters immune evasion immunized in vitro in vivo Infection K18-hACE2 mice less mice mutant naïve nasal observé pathogenicity phenotype reduced replication Replication spike gene Surveillance the SARS-CoV-2 VoC [DOI] 10.1038/s41467-022-33632-y PMC 바로가기
Assessing severe acute respiratory syndrome coronavirus 2 infectivity by reverse-transcription polymerase chain reaction: A systematic review and meta-analysisArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% confidence interval Accuracy acute respiratory syndrome Assessing Cell Cell culture cell culture system clinical heterogeneity coronavirus cycle threshold determine diagnostic estimate Evidence Genome heterogeneity indicate infectivity Infectivity limitation log Logistic regression Major Meta-analysis performed polymerase chain Positive predictive value PPV Probability protocol ranged real-time polymerase chain reaction reference test respiratory sample Respiratory samples RT-PCR SARS-CoV-2 SARS-CoV-2 RNA detection searched specificity statistical subgroup symptom onset systematic review Viral RNA virus isolation [DOI] 10.1002/rmv.2342 PMC 바로가기
D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with RemdesivirD,L-리신-아세틸살리실레이트 + 글리신(LASAG)은 SARS-CoV-2 복제를 감소시키고 렘데시비르와 함께 추가 효과를 나타냅니다Article Published on 2022-06-212022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Acetylsalicylic acid acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Additive additive effect adverse effect adverse effects Antiviral approach approved Aspirin cell culture system chip model Coagulation factors Combination complex coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cytokines disease Effect Efficacy expression glycine Healthcare system Healthcare systems in vitro inhibitory effect investigated L-lysine LASAG medication medications other diseases Patient pro-inflammation pro-inflammatory cytokine pro-inflammatory cytokines Remdesivir repurposing salt SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus show Therapeutic strategies therapeutic strategy these compound these compounds Vaccine viral infection while [DOI] 10.3390/ijms23136880 PMC 바로가기 [Article Type] Article
Of mice and human-specific long noncoding RNAs마우스 및 인간 특이적 긴 비암호화 RNAReview Published on 2022-06-012022-09-11 Journal: Mammalian genome : official journal of the Interna [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach BAC Bacterial bacterial artificial chromosome Cell culture cell culture system cell culture systems chromosome complement conducted coronavirus coronavirus disease Coronavirus disease-19 COVID-19 effort ENCODE etiologic agent example exceeded Genome highlight in vivo integration lncRNA long noncoding RNA mechanism mice MOST mouse offer pandemic protein-coding genes random receptor Regulation SARS-CoV-2 severe acute respiratory syndrome Coronavirus upstream Vascular [DOI] 10.1007/s00335-022-09943-2 PMC 바로가기 [Article Type] Review
Clinical trials with antiviral drugs against COVID-19: some progress and many shattered hopesCOVID-19에 대한 항바이러스제 임상 시험: 일부 진전과 많은 산산조각난 희망Review Published on 2021-11-012022-09-11 Journal: Environmental microbiology [Category] SARS, 치료제, [키워드] abundance accelerated Antiviral antiviral drug antiviral drugs cell culture system cell culture systems clinic clinical clinical trial clinical trials conducted COVID-19 patient COVID-19 patients demonstrated drug drug trial Effect emergency situation Evidence outcome pandemic Pragmatic reason for RECOVERY trial Repurposed drugs SARS-CoV-2 SARS-CoV-2 pandemic the SARS-CoV-2 therapy Trial Vaccine while [DOI] 10.1111/1462-2920.15769 PMC 바로가기 [Article Type] Review
In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and DiseaseReview Published on 2021-04-282022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] air–liquid interface application Cell culture cell culture system Coronaviruses COVID-19 develop disease Efficiency Ex vivo ex vivo lung globe help human airway epithelial cell culture human lung organoids in vitro in vitro lung model lung-on-a-chip mechanisms Model Replication SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 pathogenesis Spread Treatment vaccination [DOI] 10.3390/v13050792 PMC 바로가기 [Article Type] Review
Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1Kallikrein 13은 인간 코로나바이러스 HKU1에 감염되는 동안 프라이밍 프로테아제 역할을 합니다.Research Article Published on 2020-11-242022-09-25 Journal: Science Signaling [Category] 유전자 메커니즘, 진단, [키워드] blocked cause Cell cell culture system cell line cells cellular cleavage cleave cleaved complex Coronaviral coronavirus demonstrated determine distribution effort elements enzyme facilitate HCoV-HKU1 help HKU1 Host host receptor Human human airway epithelial in vitro model Infection Interaction Kallikrein KLK13 mechanism mild respiratory overexpression prevalent primary determinant priming protease Protein receptor regulate required Respiratory disease respiratory epithelial cell S protein S1/S2 SARS-CoV-2 specificity target cells the spike protein These data tissue Transmission viral entry viral pathogenesis viral replication viral S protein virus [DOI] 10.1126/scisignal.aba9902 PMC 바로가기 [Article Type] Research Article
[From the Establishment of Hepatitis B Virus Cell Culture Systems to Drug Discovery]Review Published on 2019-01-012023-06-16 Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Category] B형 간염, [키워드] bile acid cell culture system Entry Hepatitis B virus inhibitor sodium taurocholate cotransporting polypeptide [DOI] 10.1248/yakushi.18-00164-4 [Article Type] Review
Reverse Genetics for Type I Feline Coronavirus Field Isolate To Study the Molecular Pathogenesis of Feline Infectious PeritonitisResearch Article Published on 2018-07-312022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] acquisition can be used caused Cell cell culture system coronavirus Course Culture facilitate feline coronavirus field isolates Feline infectious peritonitis field function gene product genetic change genetic manipulation genetics Genome in vitro in vivo Infection infections isolate knowledge lack less lethal infection molecular Mutation other coronavirus Pathogenesis peritonitis predicted previous study progression of disease provide Research responsible reverse genetics RNA virus serotype shown specific mutations strain subsequent suggested Type virus virus stock [DOI] 10.1128/mBio.01422-18 PMC 바로가기 [Article Type] Research Article