Nucleic acid biomarkers of immune response and cell and tissue damage in children with COVID-19 and MIS-CArticle Published on 2023-04-212024-09-05 Journal: Cell Reports Medicine [Category] update2024, [키워드] bisulfite sequencing cell damage cell-free DNA cell-free RNA Clinical severity Coronavirus disease 2019 disease biomarkers DNA damage host response immune response multisystem inflammatory syndrome in children nucleic acid sequencing pediatric RNA sequencing RNA-Seq SARS-CoV-2 signaling pathways Systems biology tissue damage whole-blood RNA [DOI] 10.1016/j.xcrm.2023.101034 PMC 바로가기 [Article Type] Article
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Brief Research Report: Serum clara cell 16 kDa protein levels are increased in patients hospitalized for severe SARS-CoV-2 or sepsis infectionArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] age Anti-inflammatory Biomarker case-control study CC16 Cell cell damage chronic pulmonary diseases Concentration disease Diseases ELISA epithelial epithelial cell epithelial cell damage Evidence expressed healthy Increased Infection Infectious disease kDa Lungs Non-pulmonary patients hospitalized patients treated Platelet positively correlated previous study Protein protein level SARS-CoV-2 Sepsis Serum level severe infections severe SARS-CoV-2 significantly increased subjects were measured [DOI] 10.3389/fimmu.2022.1037115 PMC 바로가기
Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic ApproachArticle Published on 2022-09-142022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] Activation Antiviral assist binding cascade cell damage cell membrane components COVID-19 COVID-19 infection Cytokines Defense downregulate drug expression facilitate food help highlight host cells immune immune signature immune system in viral Infection Inflammation inflammatory chemokine Inflammatory response innate immune response innate immune system interfere intracellular signaling involved ligands mechanism mediation modulate molecular pathogen invasion pathogenic Protein recognizing responsible RNA SARS-CoV-2 signaling pathway therapeutic agent Therapeutic approach TLR TLR agonists TLRs Toll-like receptor type 1 interferon [DOI] 10.3390/ijms231810716 PMC 바로가기
SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stressSARS-CoV-2는 염증과 산화 스트레스에 의해 촉진되는 인간 심근세포를 감염시킵니다Article Published on 2022-09-012022-09-12 Journal: International journal of cardiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accounted acute respiratory syndrome analysed antiviral intervention Apoptosis apoptotic cardiac damage Cardiomyocytes cell damage cells change co-morbidities condition conditions COVID-19 patient Cytokine storm Donor driven by heart Heart damage heart failure infect Inflammation Inflammatory involved marker mechanism Myocardial non-infected oxidative stress Patient pro-inflammatory promote promoted protease provide Respiratory illness SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infected patient target tissue triggered ventricular viral entry virus entry [DOI] 10.1016/j.ijcard.2022.05.055 PMC 바로가기 [Article Type] Article
COVID-19 induced Diabetes: A novel presentationReview article Published on 2022-09-012022-10-05 Journal: Diabetes research and clinical practice [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] affected assumed Atypical Beta cells biochemical biochemical pathway Case series cause caused Cell cell damage Complication COVID COVID-19 COVID-19 pandemic COVID-19 patient critically ill patients Cross-sectional studies detect diabete diabetes Diabetes Mellitus Diagnosis Diagnostic Criteria dysregulation Follow-up Glucose Google Scholar homeostasis implication include Infection insulin resistance management mechanisms meta-analyses Mortality mortality rate outcome parameter Pathogenesis pathophysiological mechanism Patient Prognosis Result risk factor SARS-CoV-2 significantly higher trajectory type 2 diabetes was performed [DOI] 10.1016/j.diabres.2022.110034 [Article Type] Review article
Senescent endothelial cells are predisposed to SARS-CoV-2 infection and subsequent endothelial dysfunction노화 내피 세포는 SARS-CoV-2 감염 및 후속 내피 기능 장애에 걸리기 쉽습니다.Article Published on 2022-07-252022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome affected Alter Analysis association cause caused cell damage characterized contribute coronavirus coronavirus disease COVID-19 COVID-19 patients disease dysfunction Endothelial cell Endothelial dysfunction event exacerbated expression high mortality infect Infection Inflammation Injury investigated lung Lungs molecular pathogenesis of COVID-19 performed Post-infection Post-mortem replicate replicative reported SARS-CoV-2 SARS-COV-2 infection senescent Spread subsequent susceptible sustained systemic the SARS-CoV-2 thrombosis [DOI] 10.1038/s41598-022-15976-z PMC 바로가기 [Article Type] Article
Cerebrospinal fluid analysis of pregnant women at early stages of COVID-19Observational Study Published on 2022-07-012022-10-05 Journal: Taiwanese journal of obstetrics & gynecology [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, [키워드] absence Analysis Anosmia cell damage Central nervous system cerebrospinal fluid conducted COVID-19 COVID-19 patient COVID-19 symptom determine early stage headache Inflammation Injury material Neurological symptom Neurological symptoms NEUROLOGY pathophysiology polymerase chain Pregnancy pregnant women prospective observational study reported SARS-CoV-2 severe cases was performed women [DOI] 10.1016/j.tjog.2022.03.043 PMC 바로가기 [Article Type] Observational Study
The COVID-19 pandemic – what have urologists learned?COVID-19 전염병 - 비뇨기과 전문의는 무엇을 배웠습니까?Review Published on 2022-06-012022-09-11 Journal: Nature reviews. Urology [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, [키워드] ACE2 Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting AKI androgen angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 caused cell damage changes in clinical study Complication complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic damage Deprivation Economy expressed genitourinary tract high risk hypogonadism impairment in urine Invasion organ organs outbreak pandemic patients with COVID-19 public health raising receptor reported respiratory tract SARS-CoV-2 secondary hypogonadism Semen severe acute respiratory syndrome Coronavirus spermatogenesis survival Symptom testes Testosterone the WHO therapy tract treating COVID-19 Urine [DOI] 10.1038/s41585-022-00586-1 PMC 바로가기 [Article Type] Review
Cytokeratin 18 cell death assays as biomarkers for quantification of apoptosis and necrosis in COVID-19: a prospective, observational studyCOVID-19에서 세포자멸사 및 괴사의 정량화를 위한 바이오마커로서의 Cytokeratin 18 세포 사멸 분석: 전향적 관찰 연구Observational Study Published on 2022-06-012022-09-11 Journal: Journal of Clinical Pathology [Category] Coronavirus, COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] admitted patients Adult patients Apoptosis appear assays Biomarker blood sample Blood samples Care caspase cell damage cell death clinical trials collected Control controls COVID-19 COVID-19 patient COVID-19 patients cytokeratin discharged patients elevated emergency department enrolled enzyme epithelial epithelial cell estimation hospitalisation hospitalised hospitalised COVID-19 patients ICU admission independent predictor independent predictors Intact intensive care unit mechanism multivariable logistic regression Necrosis non-ICU Patient patients patients with COVID-19 presenting quantification relative contribution relative contributions respiratory respiratory symptom respiratory symptoms risk stratification SARS-CoV-2 severe disease sick therapeutic efficacy Trigger triggers Virology [DOI] 10.1136/jclinpath-2020-207242 PMC 바로가기 [Article Type] Observational Study