Post-Acute Sequelae and Mitochondrial Aberration in SARS-CoV-2 InfectionReview Published on 2024-08-212024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] autophagy cell metabolism Innate immunity Long COVID Mitochondria mitophagy mtDNA PASC reactive oxygen species SARS-CoV-2 [DOI] 10.3390/ijms25169050 PMC 바로가기 [Article Type] Review
The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer ManagementReview Published on 2024-07-182024-09-05 Journal: Cancers [Category] update2024, [키워드] Anticancer agent antitumor drugs Cancer cell metabolism Chemotherapy Curcuminoid drug delivery drug targeting nanoparticle oxidative phosphorylation oxidative stress photochemotherapies photodynamic therapy Tumor turmeric [DOI] 10.3390/cancers16142580 PMC 바로가기 [Article Type] Review
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics Reviews Published on 2022-07-072022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 신약개발, [키워드] Activation addition biological processes Cancer Cell cell metabolism cell proliferation cellular pathways change Chronic diseases disease Diseases downstream gene drugs Endoplasmic reticulum ERK expression Extracellular Factor Glycolysis Health hypoxia immune response implication Infection interact involved kinase mammalian cells mechanism Metastasis microbe Molecular oxygen NF-κB nuclear oxygen pathogenic pathway question Rapamycin reaction regulate respond responses Signaling Stress subsequent therapeutic therapeutic target tumorigenesis [DOI] 10.1038/s41392-022-01080-1 [Article Type] Reviews
The Role of Vitamin D in SARS-CoV-2 Infection and Acute Kidney InjurySARS-CoV-2 감염 및 급성 신장 손상에서 비타민 D의 역할Review Published on 2022-07-012022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition AKI alveolar Anti-inflammatory Anti-inflammatory effects antioxidant benefit broad spectrum calcium Cell cell metabolism Chronic kidney disease CKD contribute Control coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 severity Critically ill Critically ill patient critically ill patients cytokine release deficiency described Effects endothelial damage essential nutrient Genes homeostasis hormone in-hospital mortality Infection influence Innate immunity involved Kidney disease manifestation mechanism metabolism mitochondrial modulation molecular Mortality non-genomic nuclear outcome Pathologies Pathways phosphate proinflammatory recruitment regulate risk role SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe coronavirus disease Side effects targets therapeutic strategy Toxicity Transcription Vitamin Vitamin D vitamin D deficiency vitamin D level vitamin D serum Vitamin D supplementation [DOI] 10.3390/ijms23137368 PMC 바로가기 [Article Type] Review
2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart2 deoxy-D-glucose는 심장의 미토콘드리아 호흡 사슬을 증가시킵니다.Article Published on 2022-04-272022-09-11 Journal: Scientific Reports [Category] Coronavirus, COVID19(2023년), SARS, 비임상, [키워드] 2-deoxy-D-glucose accompanied appear approval benefit breath caused cell metabolism clinical trial COVID-19 COVID-19 disease cultured cell cultured cells detrimental effect disease elevated explain fibrosis Glucose Glycolysis heart hypertrophy in vivo increase in India induce metabolism mice mitochondrial Mitochondrial function murine occur opposite oxidative patients with COVID-19 pleiotropic effect Pleiotropic effects Propagation proteome represse Respiration respiratory chain restrict SARS-CoV-2 infected cells SARS-COV-2 infection stimulate Treatment vacuolization viral replication virus while [DOI] 10.1038/s41598-022-10168-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolismSARS-COV-2 감염은 B- 세포 대사를 강화함으로써 B 세포에서 CD19 발현을 하향 조절함으로써 회수 된 환자에서 면역 결핍을 유발한다.Article Published on 2021-09-222022-08-31 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 진단, [키워드] Adaptive immunity B cell B cells B-cell B-cell response BCR cause caused CD19 cell metabolism changed characterized COVID-19 downregulating dysregulation expression frequencies Frequency healthy control healthy controls immune Immune phenotype immune regulation immunodeficiency Immunological disorders Intervention memory B cell memory B cells metabolism Patient Population Recovered COVID-19 patients recovered patient recovered patients reduced SARS-COV-2 infection Signaling significantly significantly increased Stimulation subset [DOI] 10.1038/s41392-021-00749-3 PMC 바로가기 [Article Type] Article
Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2Review Published on 2021-08-232022-10-30 Journal: The Journal of Venomous Animals and Toxins Including Tropical Diseases [Category] COVID-19, [키워드] ACE2 Cell cell metabolism Clinical symptoms consequence COVID-19 pandemic Cytokine storm cytosol detect DNA Effect enrolment example hidden Host host cell immune immune responses innate receptors Interaction lung mechanism Mitochondria mitochondrial Mitochondrial function Pathogenesis Pathways Proinflammatory response receptor replicative respond robust SARS-CoV-2 signaling pathway the disease therapeutic interventions viral infection virus [DOI] 10.1590/1678-9199-JVATITD-2020-0183 PMC 바로가기 [Article Type] Review
Thromboembolic Complications of SARS-CoV-2 and Metabolic Derangements: Suggestions from Clinical Practice Evidence to Causative AgentsReview Published on 2021-05-252022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] ACE2 administration Affect agent angiotensin-converting enzyme 2 binding bleeding Causative cause cell metabolism cellular receptor ChAdOx1 nCoV-19 clinical Clinical severity Comorbidity Complication COVID-19 Cytokines higher risk human host implicated infect Infection Inflammation issue mechanism metabolic metabolism Mild multi organ support oxygen supplementation pathophysiology Patient positive Practice respiratory Respiratory Support RNA SARS-CoV-2 SARS-COV-2 infection ssRNA Stratification suggestion systemic illness systemically the disease thrombosis thrombotic complication Treatment Vaccine viral spike protein widespread β-coronavirus [DOI] 10.3390/metabo11060341 PMC 바로가기 [Article Type] Review
Chemistry and biology of ferritin페리틴의 화학 및 생물학Review Published on 2021-05-122022-09-11 Journal: Metallomics : integrated biometal science [Category] SARS, 바이오마커, [키워드] Biological functions Biology Biomarker Cancer Cell cell metabolism cellular cellular compartment Chemical biology Chemistry coronavirus disease Coronavirus disease 2019 described disease Diseases essential element ferritin Ferroptosis function functions impairment implicated iron iron homeostasis metabolism Protein reactivity required Research secreted variety [DOI] 10.1093/mtomcs/mfab021 PMC 바로가기 [Article Type] Review
Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor MicroenvironmentImmunology Published on 2021-04-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulating Acidic activate addition Amino acid amino acid transporter anti-tumor immunity c-MYC Cancer caused Cell cell metabolism chimeric antigen receptor demonstrated ENhance Evidence Express expression function functions Glucose Glutamine growth hypoxic Immune cell immune cells immunometabolism Immunotherapy induce infiltration Invasion leucine limitation metabolism metabolites mTORC1 Natural killer cells nutrient transporters overcome plasma membrane Potential proliferation promote regulatory pathway required robust SLC1A5 SLC3A2 SLC7A5 Strategy subcellular subunit T cells targeting therapy transcription factor Tumor tumor microenvironment tumors [DOI] 10.3389/fimmu.2021.624324 PMC 바로가기 [Article Type] Immunology