The role of zinc sulfate in enhancing cellular and humoral immune responses to foot-and-mouth disease vaccineArticle Published on 2023-08-092024-09-05 Journal: Virus Research [Category] update2024, [키워드] Cellular and humoral immunity foot-and-mouth disease vaccine adjuvant viral disease zinc sulfate [DOI] 10.1016/j.virusres.2023.199189 PMC 바로가기 [Article Type] Article
Protective Immunity of COVID-19 Vaccination with ChAdOx1 nCoV-19 Following Previous SARS-CoV-2 Infection: A Humoral and Cellular InvestigationArticle Published on 2022-08-302022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] activated acute respiratory syndrome antibody Antibody Response caused CD4+ naïve Cell cellular Cellular and humoral immunity cellular response ChAdOx1 ChAdOx1 nCoV-19 Cohort COVID-19 COVID-19 group D-dimer level DAV death effective faster humoral Humoral immunity Hybrid immunity IFN-γ IgG immune response Immunity increase in individual individuals induce infected individual interferon-γ investigated investigation Lymphocytes memory memory B cells naïve neutralizing antibody positive correlation SARS-CoV-2 SARS-CoV-2 vaccine secretion significant difference Support triggered vaccinated individual vaccination Vaccine with COVID-19 [DOI] 10.3390/v14091916 PMC 바로가기
Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trialChAdOx1 nCoV-19 또는 BNT162b2 2회 접종 및 BNT162b2(COV-BOOST) 3차 접종 후 4차 접종으로 제공된 BNT162b2 및 mRNA-1273 COVID-19 백신의 안전성, 면역원성 및 반응성: 다기관, 맹검, 단계 2, 무작위 시험Clinical Trial Published on 2022-08-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 1:1 95% CI adverse event All participants analysed anti-spike protein IgG assigned blinded block size BNT162b2 boost booster Booster vaccine cellular Cellular and humoral immunity Cellular immune response ChAdOx1 nCoV-19 computer-generated Concentration Controlled trial country COV-BOOST COVID-19 COVID-19 vaccine COVID-19 vaccines dose doses Effectiveness ELISA ELISPOT Endpoint enrolled fatigue female Fold change Fold changes force geometric geometric mean groups Humoral immunity immunogenicity Intramuscular injection IQR ISRCTN Laboratory Local male median age median interval Moderna modified intention-to-treat mRNA mRNA-1273 mRNA-1273 booster mRNA-1273 COVID-19 vaccine multicentre of BNT162b2 outcome participant peak per-protocol population Pfizer-BioNTech Phase 2 random randomisation list randomised controlled trial Randomised trial Randomly reactogenicity receive Registered reported representing response Safety SARS-CoV-2 screened Serious Adverse Event seronegative participant seronegative participants serostatus Seven significant increase statistician T-cell Response T-cell responses Task Force the vaccine the vaccines titre treatment allocation Trial upper arm Vaccine variant were assessed wild-type [DOI] 10.1016/S1473-3099(22)00271-7 PMC 바로가기 [Article Type] Clinical Trial
Cellular and Humoral Immunity to SARS-CoV-2 Infection in Multiple Sclerosis Patients on Ocrelizumab and Other Disease-Modifying Therapies: A Multi-Ethnic Observational StudyOcrelizumab 및 기타 질병 수정 요법을 사용하는 다발성 경화증 환자의 SARS-CoV-2 감염에 대한 세포 및 체액 면역: 다민족 관찰 연구Observational Study Published on 2022-06-012022-09-11 Journal: Annals of neurology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] age ANN antibody Antibody Response Antibody responses assays association Asymptomatic cellular Cellular and humoral immunity Cellular and humoral responses Cellular immune response chemiluminescence immunoassay Clinical course Clinical severity coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 determine domain Effect ELISA ELISPOT ELISpot assays enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated Evidence evidence of group Hospitalized humoral Humoral and cellular immune responses Humoral immunity Humoral response humoral responses IFNγ IL-2 immune responses immunoassay immunologic response immunologic responses Infection Laboratory Live virus microneutralization MOST Multiple multiple sclerosis multivariate analyses Multivariate analysis N-terminal domain Natalizumab not differ Ocrelizumab Other Patient performed Protein RBD receptor recruited respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sclerosis Severe acute respiratory syndrome severity Spearman sphingosine spike Spike protein symptomatic infection T-cell Response T-cell responses therapy with COVID-19 [DOI] 10.1002/ana.26346 PMC 바로가기 [Article Type] Observational Study
Evaluation of the QuantiFERON SARS-CoV-2 interferon-ɣ release assay in mRNA-1273 vaccinated health care workersmRNA-1273 백신을 접종한 의료 종사자의 QuantiFERON SARS-CoV-2 인터페론-ɣ 방출 분석 평가Article Published on 2021-12-012022-09-11 Journal: Journal of virological methods [Category] SARS, 변종, 진단, [키워드] cellular Cellular and humoral immunity Cellular immune response cellular immune responses cellular immunity clinical medicine Cohort concern COVID-19 current diagnostic evaluate evaluated focus Health care Health care worker health care workers hepatitis B humoral Humoral immunity Humoral response immune responses indicate INF-ɣ Laboratory mRNA mRNA-1273 mRNA-1273 vaccine novel peptide peptide pool Qiagen QuantiFERON responders SARS-CoV-2 SARS-CoV-2 vaccines serology vaccination Vaccinations VOCs [DOI] 10.1016/j.jviromet.2021.114295 PMC 바로가기 [Article Type] Article
Plasmodium falciparum-infected humanized mice: a viable preclinical toolarticle Published on 2021-11-302024-09-01 Journal: Immunotherapy [Category] 말라리아, [키워드] CD34 Cellular and humoral immunity FRG HSC immune response knock-out NSG NSG mice PfhuHep-TK-NOG Plasmodium falciparum Vaccine [Article Type] article
Route of infectious bronchitis virus vaccination determines the type and magnitude of immune responses in table egg laying hensResearch Article Published on 2021-11-122022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] Administered administration age avian coronavirus cellular Cellular and humoral immunity cellular immunity chicken comparable demonstrated detection determine dissemination early time-points gene transcription greater group groups humoral immune response Humoral immunity IBV IgA immune immune response Immunity Infectious Bronchitis Virus Innate interval layer chicken magnitude mass Massachusett mRNA level mucosal mucosal immune responses RNA load robust route serotypes significantly significantly higher Strains timepoints tissue tissues transcript up-regulated vaccination Vaccine vaccine strain Vaccines virus virus clearance [DOI] 10.1186/s13567-021-01008-7 PMC 바로가기 [Article Type] Research Article
[Are SARS-CoV-2 reactive T cells detectable and potentially protective in patients under anti-CD20 treatment with an impaired humoral response?][SARS-CoV-2 반응성 T 세포는 체액성 반응이 손상된 항-CD20 치료를 받는 환자에서 감지 가능하고 잠재적으로 보호 가능한가요?]Article Published on 2021-11-012022-09-11 Journal: Zeitschrift Fur Rheumatologie [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-CD20 treatment antibody formation B cell cellular Cellular and humoral immunity Cellular immune response changed chronic inflammatory disease chronic inflammatory diseases Contact coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 depleting detectable effective English fatality framework Gut humoral Humoral immunity immune system Immunosuppression Infection Inflammatory diseases less life Masks monoclonal antibody obligatory organ Organ transplant pandemic pathogen Patient patients treated Probability Protective reactive recent Rheumatic diseases risk rituximab RTX SARS-CoV-2 SARS-CoV‑2 SARS-CoV‑2 vaccination. severe acute respiratory syndrome Coronavirus severity Spread T cell vaccination Vaccinations virus Welt [DOI] 10.1007/s00393-021-01083-3 PMC 바로가기 [Article Type] Article
Evidence of Long-Lasting Humoral and Cellular Immunity against SARS-CoV-2 Even in Elderly COVID-19 Convalescents Showing a Mild to Moderate Disease ProgressionArticle Published on 2021-08-092022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] age anti-SARS-CoV-2 antibody Cellular and humoral immunity Cellular immune response Cohort concerning convalescent COVID-19 detectable domain Donor donors elderly elevated ELISA assay Epitopes equipment evaluate evidence of flow cytometry healthy controls humoral Humoral immunity IFN-γ Immune cell Immunity individuals interferon-γ knowledge Laboratory leucocyte long-lasting membrane Mild Moderate COVID-19 Multiplex assay natural killer cell NK-cells no difference nucleocapsid protein performed persistence post infection previous study provide SARS-CoV-2 SARS-CoV-2-specific peptides significantly specimen subpopulations viral spike while [DOI] 10.3390/life11080805 PMC 바로가기 [Article Type] Article
Immunogenicity generated by mRNA vaccine encoding VZV gE antigen is comparable to adjuvanted subunit vaccine and better than live attenuated vaccine in nonhuman primatesArticle Published on 2020-08-102023-05-31 Journal: Vaccine [Category] 대상포진, 두창, 수두, 홍역, [키워드] Adjuvanted subunit protein Cellular and humoral immunity Immune response durability Live attenuate virus mRNA encoding antigen. Vaccine Varicella-Zoster Virus [DOI] 10.1016/j.vaccine.2020.06.062