CNS, Central Nervous System – Communicable Diseases Research

Central nervous system (CNS) inflammatory demyelinating diseases (IDDs) associated with COVID-19: A case series and review

Short Communication

Published on 2022-08-012024-09-04
Journal: Journal of neuroimmunology [Category] 대상포진,

A network biology approach to identify crucial host targets for COVID-19

Article

Published on 2022-03-292023-07-02
Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS,

[키워드] 2019-nCoV, 2019 novel coronavirus AAV2, Adeno-associated virus AP-MS, Affinity purification-mass spectrometry ARDS, acute respiratory distress syndrome ARDS, adult respiratory distress syndrome BC, Betweenness centrality BP, Biological process CC, Cellular component CC, Closeness centrality CDK5RAP2, Cyclin dependent kinase 5 regulatory subunit associated protein 2 CNS, Central Nervous System COVID-19 COVID-19, coronavirus disease-2019 DC, Degree centrality Drug repurposing EC, eigenvector centrality functional annotation GO, Gene ontology HCMV, Human cytomegalovirus HCV, hepatitis C virus HIV-1, human immunodeficiency virus 1 IL-2, interleukin-2 MERS-CoV, Middle East respiratory syndrome coronavirus MF, Molecular function MgADP, Magnesium ADP MgATP, Magnesium ATP network biology Novel coronavirus PD-L1, Programmed death-ligand 1 PKA, protein kinase A PPIN, Protein-Protein interaction network PPIs, Protein-Protein interactions Rank aggregation RdRP SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 VSV, Vesicular stomatitis virus
[DOI] 10.1016/j.ymeth.2022.03.016 PMC 바로가기 [Article Type] Article

Thermal dysregulation in patients with multiple sclerosis during SARS-CoV-2 infection. The potential therapeutic role of exercise

Review Article

Published on 2022-01-242023-06-16
Journal: Multiple sclerosis and related disorders [Category] MERS, SARS,

[키워드] ANS Autonomic nervous system APN, Adiponectin CNS, Central Nervous System COVID-19, coronavirus disease-2019 EDHF, Endothelial-derived hyperpolarizing factor eNOS, endothelial nitric oxide synthase exercise MS, multiple sclerosis multiple sclerosis NLRP3, NLR family pyrin domain containing 3 NO, Nitric Oxide PACAP, Pituitary adenylate cyclase-activating polypeptide PAMPs, pathogen-associated molecular patterns PGE₂, Prostaglandin E₂ PGs, Prostaglandins ROS, reactive oxygen species SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SNS, Sympathetic nervous system sweat gland Thermoregulation TRPV-1, Transient receptor potential vanilloid type 1 VDP, Vascular-dilating prostanoids VEGF, Vascular endothelial growth factor VIP, Vasoactive intestinal peptide
[DOI] 10.1016/j.msard.2022.103557 PMC 바로가기 [Article Type] Review Article

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

Article

Published on 2021-09-132022-11-01
Journal: International immunopharmacology [Category] COVID-19, MERS, SARS,

[키워드] “cytokine storm” A1, adenosine 1 receptor A2A, adenosine 2A receptor A2B, adenosine 2B receptor A3, adenosine 3 receptor Abstract ACE2 ACE2, angiotensin II-converting enzyme ACh, Acetylcholine Activation acute respiratory syndrome ADA, adenosine deaminase adenosine Ado, adenosine nucleoside ADP, adenosine diphosphate AEC, alveolar epithelial cell AK, adenosine kinase ALP, alkaline phosphatases alveolar epithelial cell AM, alveolar macrophages AMP, adenosine monophosphate APC, antigen presenting cell ARDS, acute respiratory distress syndrome ATP ATP, adenosine triphosphate binding CCL, chemokine ligand with CC motif CD, cluster of differentiation CDC, Centers for Disease Control and Prevention characterized CLR, C-type lectin receptor CNS, Central Nervous System CNT, concentrated nucleoside transporters COPD, Chronic obstructive pulmonary disease coronavirus coronavirus disease cough COVID-19 COVID-19, coronavirus disease CT, Computed tomography cytokine DAMP, danger-associated molecular pattern death Defense difficulty breathing E protein, envelope protein E-5′-NT, ecto-5′-nucleotidase E-NPP, ectonucleotide pyrophosphatase/ phosphodiesterase E-NTPDase, ectonucleoside triphosphate diphosphohydrolase effective ENT, balanced nucleoside transporters enzyme etiological agent expressed FDA, Food and Drug Administration Fever G-CSF, granulocyte colony-stimulating factor GABA, γ-amino butyric acid GVHD, Graft-versus-host disease H1N1, influenza type A subtype H1N1 virus HIF, hypoxia-inducible factor ICTV, International Committee on Taxonomy of Viruses ICU, Intensive care unit IFN-γ, interferon gamma IFN-I, type I interferon IGG, immunoglobulin g IGM, immunoglobulin m IL-1β, interleukin 1 beta IL, interleukin immune immune cells immune system infecting Infection Inflammation Interaction involved IP-10, interferon gamma-induced protein 10 IPF, Idiopathic pulmonary fibrosis Lung disease M protein, membrane protein MCP-1, monocyte chemotactic protein 1 mechanism MERS-CoV, Middle East respiratory syndrome MHC-I, major histocompatibility complex class I MHC-II, major histocompatibility complex class II MIP-1α, macrophage inflammatory proteins 1-alpha modulation N protein, nucleocapsid protein NAc, nucleus accumbens NET, neutrophil extracellular traps NK, natural killer NLRP3, NOD-, LRR- and pyrin domain-containing protein 3 organ P1, type 1 purinergic receptor P2, type 2 purinergic receptor P2X7 pandemic Pneumonia Protein purinergic signaling receptor receptors reduce Replication respiratory tract responsible RNA, Ribonucleic acid ROS, reactive oxygen species RT-PCR, Reverse transcription polymerase chain reaction S protein, spike protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 virus SARS-CoV, severe acute respiratory syndrome coronavirus SARS, Severe acute respiratory syndrome severity Signaling single-stranded RNA virus suppress targeting the Coronaviridae the cytokine storm the disease therapy tissue TNF-α, tumor necrosis factor alpha Treatment Trigger viral surface virus WHO, World Health Organization with COVID-19
[DOI] 10.1016/j.intimp.2021.108150 PMC 바로가기 [Article Type] Article

Mucormycosis: An opportunistic pathogen during COVID-19

Review

Published on 2021-07-062023-06-15
Journal: Environmental research [Category] MERS, SARS,

[키워드] AML, Acute Myeloid Leukemia CD4⁺ T, cluster of differentiation 4 T-helper cells CNS, Central Nervous System CotH, Spore coat protein COVID-19 COVID19, Coronavirus Disease 2019 CT, Computed tomography diabetes Environmental pollution ICU, Intensive care unit IFN-γ, Interferon-gamma IL-10, Interleukin −10 IL-17, Interleukin −17 IL-4, Interleukin-4 Immunosuppression LIFE, Leading International Fungal Education Mucormycosis NK cells, Natural Killer cells Normal T-cell Expressed and Secreted organ damage PDGFRB, Platelet-Derived Growth Factor Receptor B RANTES, Regulated upon Activation Normal T-cell Expressed and Secreted ROCM, Rhino-Orbital Cerebral Mucormycosis SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SSTI, Skin and Soft Tissue Infection Steroids WHO, World Health Organization
[DOI] 10.1016/j.envres.2021.111643 PMC 바로가기 [Article Type] Review

The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

Article

Published on 2021-06-182023-06-15
Journal: Cytokine & growth factor reviews [Category] MERS, SARS,

[키워드] ACE2, angiotensin-converting enzyme 2 ALI, Acute Lung Injury Ang II, Angiotensin II ARDS, acute respiratory distress syndrome ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain AT1R, Ang II type 1 receptor BBB, blood-brain barrier CARD, caspase recruitment domain CNS, Central Nervous System COVID-19 COVID-19, Coronavirus disease 2019 CXCL10, C-X-C motif chemokine ligand 10 DAMPs, damage-associated molecular patterns ERGIC, endoplasmic reticulum-Golgi apparatus intermediate compartment ERK, extracellular signal-regulated kinase IFN, interferon IL-18/1β/6/8/10/1RA, interleukin-18/1β/6/8/10/1RA inhibitor LDH, lactate dehydrogenase LPS, lipopolysaccharide LRR, , leucine-rich repeat MAC, membrane attack complex MASP2, MBL-associated serine protease 2 MBL, mannan-binding lectin MEK, mitogen-activated protein kinase MERS-CoV, middle east respiratory syndrome coronavirusus mtDNA, mitochondrial DNA NEK7, never in mitosis A-related kinase 7 NETs, neutrophil extracellular traps NF-κB, Nuclear Factor kappa B NLRP3 inflammasomeome NLRP3, nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 ORF3a/8a/8b, open reading frame 3a/8a/8b P2 × 7, P2X purinergic receptor 7 PAMPs, pathogen-associated molecular patterns Pathogenesis PKR, double-stranded RNA-dependent protein kinase PYD, pyrin domain ROS, reactive oxygen species S/M/N/E protein, spike/membrane/nucleocapsid/envelope protein SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 TMPRSS2, Transmembrane serine protease 2 TNF, Tumor Necrosis Factor
[DOI] 10.1016/j.cytogfr.2021.06.002 PMC 바로가기 [Article Type] Article

SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

Article

Published on 2021-02-192023-06-16
Journal: Cytokine & growth factor reviews [Category] MERS, SARS,

Nicotinic cholinergic system and COVID-19: In silico evaluation of nicotinic acetylcholine receptor agonists as potential therapeutic interventions

Regular Article

Published on 2020-12-192022-10-04
Journal: Toxicology Reports [Category] 신약개발, 유전자 메커니즘,

[키워드] Abstract Acetylcholine Acetylcholine-binding protein ACh, Acetylcholine AChAcetylcholine AChBP, Acetylcholine-binding protein AChBPAcetylcholine-binding protein acute respiratory distress syndrome agonist agonists Anti-inflammatory approved ARDS, acute respiratory distress syndrome ARDSacute respiratory distress syndrome Basic Local Alignment Search Tool binding BLAST, Basic Local Alignment Search Tool BLASTBasic Local Alignment Search Tool Central nervous system CHARMM, Chemistry at Harvard Macromolecular Mechanics CHARMMChemistry at Harvard Macromolecular Mechanics Chemistry at Harvard Macromolecular Mechanics cholinergic Cholinergic agonists clinical manifestation CNS, Central Nervous System CNSCentral Nervous System complexes condition constant number coronavirus CoV, coronavirus CoVcoronavirus COVID-19 DCD, single precision binary FORTRAN DCDsingle precision binary FORTRAN disorder dysregulation ECD, extracellular domain ECDextracellular domain energy epitope extracellular domain glycoprotein HADDOCK, High Ambiguity Driven protein-protein DOCKing HADDOCKHigh Ambiguity Driven protein-protein DOCKing High Ambiguity Driven protein-protein DOCKing High-mobility group protein 1 HMGB1, High-mobility group protein 1 HMGB1High-mobility group protein 1 homologous hospitalized COVID-19 patients Hypothesis IL, interleukin ILInterleukin in vitro in vivo Inflammatory Interaction interleukin Jak2, Janus kinases 2 Jak2Janus kinases 2 Janus kinases 2 LBD, Ligand Binding Domain LBDLigand Binding Domain lig, ligand Ligand Ligand Binding Domain ligligand MD, molecular dynamics MDMolecular Dynamics MDS, Molecular Dynamics Simulations MDSMolecular Dynamics Simulations MERS, Middle East respiratory syndrome MERSMiddle East Respiratory Syndrome Middle East respiratory syndrome molecular dynamics molecular dynamics simulations nAChRs, nicotinic acetylcholine receptors nAChRsnicotinic acetylcholine receptors NAMD, Nanoscale Molecular Dynamics NAMDNanoscale Molecular Dynamics Nanoscale Molecular Dynamics National Center for Biotechnology Information NCBI, National Center for Biotechnology Information NCBINational Center for Biotechnology Information NCS, Nicotinic Cholinergic System NCSNicotinic Cholinergic System neurological NF-kB, nuclear factor kappa-light-chain-enhancer of activated B cells NF-kBnuclear factor kappa-light-chain-enhancer of activated B cells Nicotinic acetylcholine receptors Nicotinic Cholinergic System NPT, constant number, pressure, energy NPTconstant number nuclear factor kappa-light-chain-enhancer of activated B cells NVT, constant number, volume, energy NVTconstant number pandemic Particle Mesh Ewald patients with COVID-19 PDB, Protein Data Bank PDBProtein Data Bank PME, Particle Mesh Ewald PMEParticle Mesh Ewald pressure Prevalence Prevent PRODIGY, PROtein binDIng enerGY prediction PRODIGYPROtein binDIng enerGY prediction PROtein binDIng enerGY prediction Protein Data Bank PyMOL, Python Molecule PyMOLPython Molecule Python Molecule RBD, receptor binding domain RBDReceptor Binding Domain receptor Receptor binding domain RMSD, Root-mean-square deviation RMSDRoot-mean-square deviation Root-mean-square deviation SARS - 2 Spike Subunit 1 protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 S1, SARS - 2 Spike Subunit 1 protein SARS-CoV-2 S1SARS - 2 Spike Subunit 1 protein SARS, Severe acute respiratory syndrome SARSSevere Acute Respiratory Syndrome Saturation Transfer Difference Nuclear Magnetic Resonance Scientific community Severe acute respiratory syndrome severe COVID-19 severe symptoms signal transducer and activator of transcription 3 significantly single precision binary FORTRAN smoker smoking spike spike glycoprotein STAT3, signal transducer and activator of transcription 3 STAT3signal transducer and activator of transcription 3 STD NMR, Saturation Transfer Difference Nuclear Magnetic Resonance STD NMRSaturation Transfer Difference Nuclear Magnetic Resonance substrate Symptom System the SARS-CoV-2 Therapeutic approach therapeutic intervention therapeutic option TNF, Tumor Necrosis Factor TNFTumor Necrosis Factor toxins triggering tumor necrosis factor Visual Molecular Dynamics VMD, Visual Molecular Dynamics VMDVisual Molecular Dynamics Volume
[DOI] 10.1016/j.toxrep.2020.12.013 PMC 바로가기 [Article Type] Regular Article

Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy

Article

Published on 2020-12-152023-06-15
Journal: Cytokine & growth factor reviews [Category] MERS, SARS,

[키워드] ACE2, angiotensin converting enzyme 2 ALI, Acute Lung Injury ARDS, acute respiratory distress syndrome BBB, blood-brain-barrier BM-MSC, bone marrow mesenchymal stromal cells CD, Crohn’s disease CM, conditioned-medium CNS, Central Nervous System COVID-19 COVID-19, Coronavirus disease of 2019 Cytokine storm cytokines/chemokines DCs, dendritic cells EVs, extracelular vesicules FDA, US Food and Drug Administration FGF7, fibroblast growth factor 7 GI, gastrointestinal GMCSF, Granulocyte-macrophage colony-stimulating factor IBD, Inflammatory bowel disease IDO, indoleamine 2,3 dioxygenase IFN-y, interferon y IL, interleukin IV, Intravenous JEV, Japanese encephalitis virus LPS, lipopolysaccharide LVEF, left ventricle ejection fraction MB-MSC, menstrual blood mesenchymal stromal cells MCP-1, monocyte chemoattractant protein 1 MERS, Middle East respiratory syndrome mesenchymal stromal/stem cells MSC, mesenchymal stromal cells NK, natural killer Pleiotropic therapy SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS, Severe acute respiratory syndrome Th, T helper TMPRSS2, Transmembrane Protease Serine 2 TNF-a, tumor necrosis factor alpha Treg, T regulatory VEGF, vascular endotelhial growth factor
[DOI] 10.1016/j.cytogfr.2020.12.002 PMC 바로가기 [Article Type] Article

An enlightening role for cytokine storm in coronavirus infection

Review Article

Published on 2020-10-232023-06-14
Journal: Clinical immunology (Orlando, Fla.) [Category] MERS, SARS,

[키워드] ACE2, angiotensin-converting enzyme 2 ALI, Acute Lung Injury ARDS, acute respiratory distress syndrome B, B lymphocyte BMSC, bone marrow stromal cell CCL, chemokine ligand CNS, Central Nervous System Coronavirus disease 2019 (COVID-19) CoV, coronavirus COVID-19, Coronavirus disease 2019 COVID-CSS, COVID-19 related cytokine storm syndrome CRP, C-reactive protein CXCL, Chemokine (C-X-C motif) ligand Cytokine storm DC, dendritic cell FGF, fibroblast growth factor GCSF, granulocyte colony stimulating factor GMCSF, Granulocyte-macrophage colony-stimulating factor IFN, Interferons IL-1RA, IL-1 receptor antagonist IL, interleukin Inflammatory cytokines IP-10, IFN-γ-inducible protein-10 IRF3, IFN regulatory factor-3 JAK, Janus kinase MCP, monocyte chemoattractant protein MERS, Middle East respiratory syndrome MIP1A, macrophage Inflammatory Protein 1 Alpha MIP1B, macrophage Inflammatory Protein 1 beta Multiple organ dysfunctions NF-κB, nuclear factor κB NK, natural killer cell NLR, neutrophil-to-lymphocyte ratio PAMPs, pathogen-associated molecular patterns PBMC, peripheral blood mononuclear cell PDGF, platelet derived growth factor PRRs, Pattern Recognition Receptors SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS, Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) STAT, Signal transducer and activator of transcription Th, helper T cell Th1, T-helper-1 cell Th2, T-helper-2 cell TLRs, Toll-like receptors TNF, Tumor Necrosis Factor VEGF, vascular endothelial cell growth factor WHO, World Health Organization
[DOI] 10.1016/j.clim.2020.108615 PMC 바로가기 [Article Type] Review Article