Causal Modeling to Mitigate Selection Bias and Unmeasured Confounding in Internet-Based Epidemiology of COVID-19: Model Development and ValidationCOVID-19의 인터넷 기반 역학에서 선택 편향과 측정되지 않은 교란을 완화하기 위한 인과 관계 모델링: 모델 개발 및 검증Article Published on 2022-07-212022-09-11 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] age applied approach Bia bias Causal Causality collected Community compatibility conditions Confounding confounding factors COVID-19 COVID-19 symptoms Critical cumulative demographic characteristics demographics design detect determine develop development Diagnosis Epidemic epidemiologic research design epidemiological Epidemiological study Epidemiology estimate Health status household infection implementation Infection infection rate internal and external Mechanical mechanism method mitigate Model modeling MTurk New New York New York City omicron Omicron variants problem protocol public health Qualtrics recent reported Research Research design response Selection selection bia Selection bias sensitivity sensitivity analysis skewed state subject Surveillance the disease Threats utility validation Validity variant [DOI] 10.2196/31306 PMC 바로가기 [Article Type] Article
A method comparison study of the high throughput automated HISCL® SARS-CoV-2 antigen assay using nasopharyngeal swab samples from symptomatic and asymptomatic subjects against conventional RT-PCR기존의 RT-PCR에 대한 증상 및 무증상 피험자의 비인두 면봉 샘플을 사용한 고속 자동화 HISCL® SARS-CoV-2 항원 분석의 방법 비교 연구Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen automated Chain Reaction collected compatibility coronavirus cycle threshold evaluate healthcare worker Healthcare workers HISCL automated antigen assay individual Infection medium method comparison Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples polymerase chain polymerase chain reaction public health rapid testing RT-PCR SARS-CoV-2 SARS-CoV-2 antigen sensitivity severe acute respiratory syndrome Coronavirus specificity subject Swab swabs symptomatic and asymptomatic tested Transport transport medium Universal Transport Medium UTM variants variants of concern viral loads viral spread yielding [DOI] 10.1002/jmv.27679 PMC 바로가기 [Article Type] Article
HYBRiD: hydrogel-reinforced DISCO for clearing mammalian bodiesHYBRiD: 포유류의 몸을 청소하기 위한 하이드로겔 강화 DISCOArticle Published on 2022-04-012022-09-11 Journal: Nature methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] antibody Chest compatibility component components demonstrated dimensions DISCO feature fluorescent hACE2 heterogeneous hybrid immunostaining K18-hACE2 transgenic mice macroscopic mammalian mice nervous system Newborn offer organ organic parvalbumin Protein reporter Research SARS-COV-2 infection solvent three dimensions translational utility Viral viral pathology Visualization [DOI] 10.1038/s41592-022-01427-0 PMC 바로가기 [Article Type] Article
Purification and mass spectrometry study of Maillard reaction impurities in five acyclic nucleoside antiviral drugsResearch article Published on 2022-04-012022-10-05 Journal: Journal of pharmaceutical and biomedical analysis [Category] 치료제, [키워드] Acyclic nucleoside antiviral drugs analyzed antiviral drug antiviral drugs API compatibility Compound condition decrease Degradation drugs FIVE Impurities increase in ingredient Maillard reaction mass spectrometry mechanism Neutral NMR spectroscopy nucleoside nucleosides purified stability Structural identification was performed [DOI] 10.1016/j.jpba.2022.114637 [Article Type] Research article
Genome sequencing of SARS-CoV-2 reveals the prevalence of variant B 1.1.7 in EgyptSARS-CoV-2의 게놈 시퀀싱은 이집트에서 변이 B 1.1.7의 유행을 보여줍니다Article Published on 2022-01-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome coronavirus Alpha Alpha variant authorization B 1.1.7 B.1.1.7 case fatality rates clade compatibility convalescent coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Egypt eight Emergency expected feasibility Government Hospitalization hospitalizations majority measure Ministry of Health Monoclonal antibody treatments neutralization new SARS-CoV-2 new strain no effect outbreak Prevalence public health raised recorded respiratory reveal Sample SARS-CoV-2 SARS-CoV-2 B.1.1.7 Sequencing sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity shown strain susceptibility the SARS-CoV-2 transmission rate Treatment protocol Vaccine variant Viral Viral transmission [DOI] 10.1016/j.meegid.2021.105191 PMC 바로가기 [Article Type] Article
A direct capture method for purification and detection of viral nucleic acid enables epidemiological surveillance of SARS-CoV-2바이러스 핵산의 정제 및 검출을 위한 직접 포획 방법으로 SARS-CoV-2의 역학 감시 가능Article Published on 2021-11-152022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, 치료기술, 치료법, [키워드] added addition appearance binding capture method compatibility complexes Concentration COVID-19 demonstrated detect Effect enzyme epidemiological Epidemiology fecal feces genetic material Genome infected individuals infectious agent inhibitor inhibitors initial MONITOR Mottle nucleic acid Nucleic acid purification nucleocapsid overcome plant primer Primers probe probes protocols purification purified qPCR qPCR assays RNA RNA virus RT-qPCR RT-qPCR assay RT-qPCR assays SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant sequenced silica spread of COVID-19 subset Surveillance Treatment utility Variability viral nucleic acid virion virions virus isolation wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.148834 PMC 바로가기 [Article Type] Article
An ultrafast SARS-CoV-2 virus enrichment and extraction method compatible with multiple modalities for RNA detectionRNA 검출을 위한 다중 양식과 호환되는 초고속 SARS-CoV-2 바이러스 농축 및 추출 방법Randomized Controlled Trial Published on 2021-10-022022-09-11 Journal: Analytica chimica acta [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Affinity nanoparticles alternative method alternative methods amplification Analysis Chain Reaction characterization characterized clinical samples clinically comparable compatibility Concordance coronavirus Coronavirus-2 COVID-19 pandemic demonstrated diagnoses Dilution dilutions double-blind study Enzymatic extraction form isothermal amplification Laboratory LAMP Loop-mediated amplification (LAMP) Loop-mediated isothermal amplification miniaturization nasopharyngeal swabs Particle pathogenicity polymerase polymerase chain polymerase chain reaction Polymerase chain reaction (PCR) positive recombinase polymerase amplification Recombinase polymerase amplification (RPA) respiratory reverse transcription reverse transcription real-time polymerase chain reaction RNA RNA eluate RNA isolation RNA virus RPA RT-PCR Saliva SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus-2 Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) solution Stage the stage transmission rate Viral viral titer viral titers viral transport media VTM zoonotic [DOI] 10.1016/j.aca.2021.338846 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical and laboratory findings and PCR results in severe and non-severe COVID19 patients based on CURB-65 and WHO severity indices임상 및 실험실 소견 및 PCR은 CURB-65를 기준으로 심각하고 비 체위 COVID 19 명의 환자를 초래하고 WHO 중증도 지수를 초래합니다.Research Published on 2021-09-172022-09-01 Journal: Virology Journal [Category] SARS, 진단, [키워드] abnormality Admission Alborz appear Asthma categories Characteristics CHD chronic heart disease clinical Clinical and laboratory findings Clinical characteristics Clinical features Comorbidities compatibility COVID-19 COVID19 patient cross-sectional CURB CURB-65 diabetes Diagnosis diagnosis of COVID-19 distribution FIVE Frequency group groups guideline heart disease Hospitalized hospitalized patient hospitalized patients hyperlipidemia hypertension inclusion criteria initial Inpatients involved Iran Laboratory laboratory findings nausea no significant difference Non-severe non-severe cases non-severe group outpatients outpatients and inpatient oxygen oxygen saturation Patient PCR positive Result rRT-PCR severe severe and non-severe cases severity significant difference Signs and symptoms Symptom symptomatic adult Symptoms the disease Treatment Trial two group two groups vital sign vital signs was performed WHO with COVID-19 [DOI] 10.1186/s12985-021-01658-1 PMC 바로가기 [Article Type] Research
A rapid and reliable liquid chromatography/mass spectrometry method for SARS-CoV-2 analysis from gargle solutions and saliva양수 용액 및 타액에서 SARS-COV-2 분석을위한 신속하고 신뢰할 수있는 액체 크로마토 그래피/질량 분석법Research Paper Published on 2021-08-242022-09-01 Journal: Analytical and bioanalytical chemistry [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Abstract Analysis approach Chain Reaction compatibility complementary diagnostic gargle solutions LC-MS Liquid chromatography mass spectrometry Multiple-reaction monitoring piloting polymerase chain polymerase chain reaction promote protocol quantitation Quantitative reproducibility reverse transcriptase RT-qPCR Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleoprotein sensitivity supplementary material Tandem mass spectrometry transcriptase Triple quadrupole [DOI] 10.1007/s00216-021-03614-y PMC 바로가기 [Article Type] Research Paper
Versatile and flexible microfluidic qPCR test for high-throughput SARS-CoV-2 and cellular response detection in nasopharyngeal swab samples고처리량 SARS-CoV-2 및 비인두 면봉 샘플의 세포 반응 검출을 위한 다목적이고 유연한 미세유체 qPCR 테스트Research Article Published on 2021-04-142022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] absence buffer bypassing cellular response clinical sample clinical samples compatibility composed contribute diagnostic diagnostic test evaluated flexible Host IMPROVE large sample limitations lysis buffer MicroRNAs nasopharyngeal swab sample offer overcome pathogen Pathogens Patient PCR reaction Population presence or absence probe proteinase Proteinase K protocols qPCR qPCR test Quantitative reaction Real-time PCR receptors reference method reverse transcription RNA extraction RNA purification RT-qPCR SARS-CoV-2 SARS-CoV-2 variants Spread test results the SARS-CoV-2 this system time-consuming virus Volume [DOI] 10.1371/journal.pone.0243333 PMC 바로가기 [Article Type] Research Article