Label free detection of SARS CoV-2 Receptor Binding Domain (RBD) protein by fabrication of gold nanorods deposited on electrochemical immunosensor (GDEI)전기화학적 면역센서(GDEI)에 증착된 금 나노막대를 제작하여 SARS CoV-2 수용체 결합 도메인(RBD) 단백질의 무표지 검출Article Published on 2022-09-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] AFM antibody binding Blot chain Chain Reaction characterized cloned collected coronavirus disease Coronavirus disease 2019 COVID-19 Cross reactivity cyclic Detection limit DPV dynamic early diagnosis Efficiency electrochemical electron electron carrier Electrophoresis ELISA enzyme enzyme-linked immunosorbent assay expressed fabrication flight fluorine followed by force FTO gel electrophoresis gold Gold nanorods house immobilization Infectious disease kDa lAbel Laser LIGHT MERS middle Middle East Middle East respiratory syndrome molecular weight nasopharyngeal sample Outbreaks output Oxide pandemic polyacrylamide Population Protein RBD RBD antigen RBD gene reaction Receptor binding domain respiratory reverse transcription Reverse transcription-polymerase chain reaction RT-PCR SARS CoV SARS CoV-2 SDS-PAGE shown Spectroscopy spike Spike protein stability TEM tested the patient Tin Tin Oxide transmission electron microscopy viral transport media VTM was determined western blot [DOI] 10.1016/j.bios.2022.114406 PMC 바로가기 [Article Type] Article
The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
Cyclic 68 Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2Basic Science Investigation Published on 2021-11-012022-10-30 Journal: Journal of Nuclear Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 ARDS binding biodistribution calculated Cohort compounds Concentration coronavirus coronavirus disease COVID-19 COVID-19 patients cyclic detect detection generate glycol hACE2 half-maximal inhibitory concentration Human humanized hypothese identify identity inhibitor linear linker liver lung Lungs modulation murine murine model organ organ injury organ-specific peptide pet Pharmacologic reduction residues SARS-CoV-2 SARS-COV-2 infection small intestine Specific susceptibility transgenic transgenic model Visual was determined was used [DOI] 10.2967/jnumed.120.261768 PMC 바로가기 [Article Type] Basic Science Investigation
Improved Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents Targeting 3C and 3CL Proteases Including SARS-CoV-2 M proSARS-CoV-2 M pro를 포함한 3C 및 3CL 프로테아제를 표적으로 하는 항바이러스제에 사용되는 고리형 글루타민 유사체의 향상된 합성Article Published on 2021-09-172022-09-11 Journal: The Journal of organic chemistry [Category] SARS, 치료제, [키워드] 3CL agent Alanine Amino acid analogue Antiviral Compound conditions cyclic form Glutamine Improved Including lack M pro methodology oxime preparation Protease inhibitor purification reagent SARS-CoV-2 synthesis targeting yielding [DOI] 10.1021/acs.joc.1c01299 PMC 바로가기 [Article Type] Article
Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity바이러스 유사 입자 백신에 cGAMP를 포함하면 면역원성이 향상됩니다.Article Published on 2021-06-182022-09-12 Journal: EMBO Reports [Category] MERS, SARS, 진단, [키워드] accompanied activate Administered Antibody titre antibody titres Antigen antigens CD4 CD8 T‐cell Cell cells cGAMP cyclic doses ENhance follicular Gag glycoprotein G Haemagglutinin immunology immunostimulatory Inclusion increase induce influenza A virus Methods & Resources mice Microbiology, Virology & Host Pathogen Interaction neutralising antibody Particle Particles platform produced Protein reduced responses SARS‐CoV‐2 spike SARS‐CoV‐2 titre type I interferon vaccination Vaccine vector vesicular stomatitis virus viral vaccine vector virus Virus neutralisation virus particle VLP VLPs [DOI] 10.15252/embr.202152447 PMC 바로가기 [Article Type] Article
Thermoplasmonic-Assisted Cyclic Cleavage Amplification for Self-Validating Plasmonic Detection of SARS-CoV-2SARS-CoV-2의 자가 검증 플라즈몬 검출을 위한 써모플라즈몬 보조 순환 절단 증폭Article Published on 2021-04-272022-09-11 Journal: ACS Nano [Category] SARS, 치료기술, [키워드] amplification approach biosensor cleavage cleaved coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cyclic cyclic cleavage amplification destruction detection environmental monitoring facilitated Fluorescent probe Fluorescent probes globe hybridized indicated Infection penetrated plasmonics probe SARS-CoV-2 thermoplasmonics. transducing Transmission Viral RNA virus [DOI] 10.1021/acsnano.1c00957 PMC 바로가기 [Article Type] Article
From Angiotensin II to Cyclic Peptides and Angiotensin Receptor Blockers (ARBs): Perspectives of ARBs in COVID-19 TherapyReview Published on 2021-01-252022-10-30 Journal: Molecules [Category] COVID-19, [키워드] ACEi administration angiotensin Angiotensin II anti-hypertensive drug ARB blocker COVID 19 COVID-19 therapy cyclic cyclic peptides enzyme homeostasis hypertensive patient infected with SARS-CoV-2 inhibitor maintain mimetics peptide PROTECT RAS receptor reduce reported sarmesin SARS-CoV-2 sartans to define transdermal delivery [DOI] 10.3390/molecules26030618 PMC 바로가기 [Article Type] Review
Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?심각한 COVID-19의 림프구 변화: STING의 지연된 과활성화?Review Published on 2020-12-012022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] ACE2 activated Activation acute respiratory syndrome affected antigen presenting cell antigen presenting cells Aspirin autophagy B cell B cell response B cells CD147 CD26 CD4+ CD8+ CD8+ T cell cGAMP cGAS change contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyclic cytokine cytokine secretion damages Delayed dinucleotide DNA DNA damage early stages Express expressed functional Gain of function Genes Host Human IL-6 immune cells induce infancy Infection inhibit inhibitor interferon IRF3 Last less lymphocyte Lymphocytes lymphopenia main receptor microbial NF-κB pathway Pneumonitis Recognition respiratory responsiveness SARS-CoV-2 severe coronavirus disease severe COVID-19 severe COVID-19 patient severe COVID-19 patients similarity SLC19A1 small molecule Small molecules stimulator STING T and B cell responses T cell T cells TBK1 TCR Th2 transfer triggered Vasculopathy [DOI] 10.3389/fimmu.2020.607069 PMC 바로가기 [Article Type] Review
Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapyReview Published on 2020-08-272022-10-30 Journal: Molecular Cancer [Category] COVID-19, [키워드] Activation adaptive agonist agonists antimicrobial immunity Antitumor response cancer development cGAS-STING Combination Comprehensive conserved Critical cyclic cytokine detect DNA downstream Evidence IFNs Immunity Immunotherapy Inflammatory cytokines innate immune system Innate immunity interferon involved malignancies mechanism microbial Pathogens pathway phenotype regulated Signaling signaling pathway STING agonists type I IFNs type I interferon [DOI] 10.1186/s12943-020-01250-1 PMC 바로가기 [Article Type] Review
Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus삼투성 항상성의 순환 di-AMP 조절은 B군 연쇄상 구균에서 필수적입니다Research Article Published on 2018-04-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulating accumulation assumed Bacteria Bacterial betaine bind binding cellular cellular physiology compensatory mutations conditions conserved Control cyclic dacA Deletion demonstrated dependent on enzyme etiological agent expression function functional glycine glycine betaine group growth homeostasis host cell host cells host-pathogen interactions hyperosmotic identification identify Infection involved leads Loss loss-of-function loss-of-function mutation maintain mechanism medium Meningitis monophosphate mutant Mutation Neonatal nucleotide nucleotides opportunistic pathogen osmolyte osmoregulation osmotic osmotic regulation pathogen pathway phenotype Potassium predominant promoter Protein regulate Regulation second messenger second messengers secondary messenger septicaemia Streptococcus Streptococcus agalactiae susceptibility Transcription transcriptional viability [DOI] 10.1371/journal.pgen.1007342 PMC 바로가기 [Article Type] Research Article