Rapid and sensitive point-of-care diagnosis of human cytomegalovirus infection using RPA-CRISPR technologyResearch Article Published on 2024-03-272024-09-05 Journal: Heliyon [Category] update2024, [키워드] CRISPR diagnosis HCMV Human Cytomegalovirus point-of-care diagnostics recombinase polymerase amplification [DOI] 10.1016/j.heliyon.2024.e28726 PMC 바로가기 [Article Type] Research Article
The impact of HLA polymorphism on herpesvirus infection and diseasearticle Published on 2023-01-032024-09-02 Journal: Curr Top Med Mycol [Category] 대상포진, [키워드] EBV HCMV herpesvirus human leukocyte antigen Immunogenetics VZV [DOI] 10.1007/s00251-022-01288-z PMC 바로가기 [Article Type] article
Antibodies to combat viral infections: development strategies and progressReview Published on 2022-06-202022-10-05 Journal: Nature Reviews Drug Discovery [Category] COVID19(2023년), SARS, 변종, 임상, 진단, 치료제, [키워드] acute respiratory syndrome antibody Antigen boost can be used caused Characteristics coronavirus COVID-19 COVID-19 pandemic develop Diseases Ebola virus effort Emergency use ENhance HCMV Human Cytomegalovirus immune responses in viral Infection Influenza mAb mAbs Neutralizing protective immune response Proteins Region respiratory syncytial virus RSV SARS-CoV-2 specificity stimulated therapeutic Vaccine design Vaccine development viral infection virus [DOI] 10.1038/s41573-022-00495-3 [Article Type] Review
Transcriptomic perspectives of memory-like NK cells and aging기억 유사 NK 세포와 노화의 전사적 관점Article Published on 2022-05-252022-09-11 Journal: Genome Medicine [Category] 유전자 메커니즘, [키워드] accumulate aging appear Cell COVID-19 COVID-19 patients disease functions HCMV highlight identity inflammaging Longevity memory Memory-like NK cells, Aging, Inflammaging, HCMV, COVID-19. molecular natural killer NK cell NK cells Perspective severity single-cell subset to define Transcriptome unique while [DOI] 10.1186/s13073-022-01059-1 PMC 바로가기 [Article Type] Article
Human herpesvirus diversity is altered in HLA class I binding peptidesBiological Sciences Published on 2022-04-292024-09-04 Journal: Proceedings of the National Academy of Sciences of [Category] 대상포진, [키워드] EBV HCMV herpesvirus HLA Population genetics [DOI] 10.1073/pnas.2123248119 PMC 바로가기 [Article Type] Biological Sciences
PPAR Ligands Induce Antiviral Effects Targeting Perturbed Lipid Metabolism during SARS-CoV-2, HCV, and HCMV InfectionReview Published on 2022-01-112022-10-28 Journal: Biology [Category] COVID-19, [키워드] acting agonist amino acids analyzed antagonist antiviral drug Compound coronavirus coronavirus disease demonstrated Effect fatty acids Glucose HCMV HCV hepatitis C virus Host identify in viral Infection infections Ligand Lipid lipid metabolism mechanism metabolism Modification novel molecule nuclear receptor Nuclear receptors nucleotides organism outcome pandemic PPAR Research researcher SARS-CoV-2 simple targeting viral infection viral infections virus [DOI] 10.3390/biology11010114 PMC 바로가기 [Article Type] Review
Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus ActivityArticle Published on 2021-11-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activity addition Adenovirus analyzed Antiviral antiviral activity antiviral drugs antiviral therapy antivirals applicability approach CDK1 CDK2 CDK7 CDK9 Chimera Clinical symptoms clinically Combined Concentration current Degradation demonstrated development Direct-acting antivirals Efficacy elements HCMV help host-directed antivirals Human Human Cytomegalovirus human/animal pathogenic viruses IMPROVE indicated inhibitor investigated kinase inhibitors mode murine new drug qualities pathogenic prevalent PROTAC-based targeting strategy PROteolysis TArgeting Chimeras required SARS-CoV-2 replication strain Strategy target targeting varicella variety virus Zika virus [DOI] 10.3390/ijms222312858 PMC 바로가기 [Article Type] Article
Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in MacrophagesArticle Published on 2021-10-152022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activated Activation analyzed cell death cleavage cleaved component CRISPR-Cas9 detect different diseases Evidence gasdermin D glycoprotein GSDMD hallmark HCMV HCV IL-1β IL-1β immune response indicated induce inflammasome activation innate immune responses innate immune system Innate immunity knowledge Lytic Macrophage macrophages mechanism NLRP3 NLRP3 inflammasome pyroptosis required responsible secretion Support tested THP-1 Trigger triggers Vaccine development variety viral entry viral glycoprotein viral glycoproteins viral pathogen viral pathogenesis viral pathogens widespread [DOI] 10.3390/v13102076 PMC 바로가기 [Article Type] Article
The emerging role of perivascular cells (pericytes) in viral pathogenesisReviews Published on 2021-08-232022-10-30 Journal: The Journal of General Virology [Category] COVID-19, SARS, [키워드] AIDS Angiogenesis antigen-presenting cell APCS blood-brain barrier cardiovascular system caused Cell cognitive complex coronavirus coronavirus disease COVID-19 dengue haemorrhage dengue virus developmental direct infection disorder dissemination dysregulation Endothelial cell endothelial cells facilitate facilitated gene product HCMV HIV/AIDS Human Human Cytomegalovirus Human immunodeficiency virus immunodeficiency in viral include Inflammatory Interaction Japanese encephalitis Major modulation neurological organ outcome Pandemics paracrine Pathogenesis pathogenic mechanism Pathogens penetration pericyte pericytes perivascular Placenta retrovirus SARS-CoV-2 secreted Symptom syndrome the disease therapy Transmission Vascular vascular leakage viral disease viral pathogenesis virus Zika virus ZIKV [DOI] 10.1099/jgv.0.001634 PMC 바로가기 [Article Type] Reviews
Affinity Tag Coating Enables Reliable Detection of Antigen-Specific B Cells in Immunospot AssaysArticle Published on 2021-07-212022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] affinity affinity tag antibody antibody-secreting cell Antigen antigen coating antigen-specific antibody antigen-specific B cell antigens approach ASC assessment B-cell coating Cohort COVID-19 vaccinations detection Donor EBV Efficiency effort engage facilitate FluoroSpot functional HCMV hexahistidine Humoral immunity Hypothesis immune Immune monitoring immune protection ImmunoSpot infectious agent Influenza information membrane memory B cell memory B-cell non-specific plasmablast platform Prevent protein concentration provide Re-infection Receptor binding domain Recombinant protein reduction in required response SARS-CoV-2 SARS-COV-2 infection secondary antibody sensitivity serum significantly single-cell spike Streamline Tag tested these cell Viral antigen [DOI] 10.3390/cells10081843 PMC 바로가기 [Article Type] Article