High-density lipoprotein – Communicable Diseases Research

Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection

Article

Published on 2021-12-222022-10-06
Journal: Clinical Science (London, England : 1979) [Category] SARS, 진단,

HDL proteome remodeling associates with COVID-19 severity

HDL 프로테옴 리모델링은 COVID-19 중증도와 관련이 있습니다.

Article

Published on 2021-11-012022-09-11
Journal: Journal of clinical lipidology [Category] MERS, 유전자 메커니즘, 진단,

[키워드] 95% confidence interval alteration Altered amyloid A APOF apoM approach clinical criteria coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 complication COVID-19 complications COVID-19 infection death diagnosed with COVID-19 Diseases displaying error rate HDL HDL-C heavy chain high-density High-density lipoprotein Hospitalization hospitalized patients Host immune response Hypothesis increase in Infection Infectious diseases Inflammatory inhibitor ITIH4 lipid metabolism metabolism Mild symptom mild symptoms Odds ratio Particle presenting Protein proteome proteomic proteomics Pulmonary Surfactant quantified Quantitative quantitative proteomics raise Saa1 SAA2 serum amyloid severe symptom severe symptoms severity severity of COVID-19 Sex SFTPB subject subjects the disease Triglyceride triglycerides two groups with COVID-19
[DOI] 10.1016/j.jacl.2021.10.005 PMC 바로가기 [Article Type] Article

Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19

저밀도 지단백 콜레스테롤 수치는 COVID-19의 좋지 않은 임상 결과와 관련이 있습니다

Article

Published on 2021-08-262022-09-11
Journal: Nutrition, metabolism, and cardiovascular diseases [Category] 바이오마커,

[키워드] 30-Day mortality 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus Admission Admitted Patient all-cause mortality Analysis association C-reactive protein causative agent cholesterol Clinical outcome Complete complete recovery coronavirus Course COVID-19 COVID-19 patients definitive diagnosis enrolled evaluate Follow-up hazard ratio High-density lipoprotein Inflammation Inflammatory marker inflammatory markers inverse correlation LDL-C Low-density lipoprotein Low-Density Lipoprotein cholesterol lymphocyte Lymphocyte count lymphopenia marker Multivariate analysis Non-survivors Patient patients performed positive correlation primary end-point profile respiratory retrospective SARS-CoV-2 SARS-COV-2 infection secondary to Serum level severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-center study Survivors the disease Total Total cholesterol triglycerides
[DOI] 10.1016/j.numecd.2021.06.016 PMC 바로가기 [Article Type] Article

Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications

Review

Published on 2021-06-012022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

[키워드] Acute kidney injury Acute kidney injury (AKI) AKI alteration anti-apoptotic anti-infection Anti-inflammatory approach Blood cholesterol clinical study complications Course disease dysfunctional HDL dysregulated elements Endothelial dysfunction feature functions HDL HDLs high risk High-density lipoprotein Host immune response Inflammation Inflammatory diseases intensive care involved kidney dysfunction lipid metabolism lipid profile changes liver mechanism Mild moderate Mortality MOST Particles Patient pleiotropic proteomic Renal involvement role SARS-CoV-2 SARS-COV-2 infection Sepsis serum significant changes in systemic inflammatory diseases systemic inflammatory response Therapies tissue Transport
[DOI] 10.3390/ijms22115980 PMC 바로가기 [Article Type] Review

Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults

조직 특이성 인식 TWAS(TSA-TWAS) 프레임워크는 HIV 양성 성인의 대사, 면역 및 바이러스 특성과의 새로운 연관성을 식별합니다.

Research Article

Published on 2021-04-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect affected AIDS Analysis applied association associations assumption Bilirubin bioinformatics CETP cholesterol cholesteryl ester clinical complex contribute current dataset enzyme eQTLs error rate evaluate experimental design expressed expression expression quantitative trait loci False positive Gene Expression Genes greater group High-density lipoprotein High-density lipoprotein cholesterol highlighting identify Laboratory loci mechanisms methodology multiple tissues novel association plasma pleiotropic gene power previous study promote Protein provide Quantitative regulated Regulatory replicated Research robust specificity statistical tissue tissues total bilirubin total bilirubin levels traits transcriptional transcriptionally transcriptome-wide transfer Triglyceride type I type I error UGT1A1 uridine uridine diphosphate variety Viral Viral load
[DOI] 10.1371/journal.pgen.1009464 PMC 바로가기 [Article Type] Research Article

Diffusion and Relaxation Edited Proton NMR Spectroscopy of Plasma Reveals a High-Fidelity Supramolecular Biomarker Signature of SARS-CoV-2 Infection

플라즈마의 확산 및 이완 편집된 양성자 NMR 분광법은 SARS-CoV-2 감염의 고충실도 초분자 바이오마커 시그니처를 보여줍니다

Article

Published on 2021-03-022022-09-11
Journal: Analytical Chemistry [Category] MERS, SARS, 바이오마커, 진단,

[키워드] age-matched control Analysis applied Biomarker carried choline classification Combination Comparator group component Concentration Control COVID-19 diagnostic diagnostics discriminant analysis elevated experiments following functional Functional assessment glycoprotein Glycoproteins healthy high-density High-density lipoprotein Hospitalized identity low-density Low-density lipoprotein Magnetic resonance spectroscopy marker metabolite metabolites molecular molecular markers negative patients NMR not significantly different nuclear nuclear magnetic resonance Patient patients phospholipid Phospholipids plasma positive Principal component principal component analysis proton Receiver operator characteristic reduced Relaxation respiratory rRT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patient SARS-CoV-2 positive patients SARS-CoV-2 positivity selected signature significantly Spectroscopy statistical Structure Symptoms the disease was determined
[DOI] 10.1021/acs.analchem.0c04952 PMC 바로가기 [Article Type] Article

Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19

COVID-19 성인 입원 환자의 생존자와 비생존자의 실험실 마커의 시간적 변화

Comparative Study

Published on 2020-12-112022-08-31
Journal: BMC Infectious Diseases [Category] MERS, SARS, 바이오마커,

[키워드] acidity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 albumin albumin-globulin ratio alkaline phosphatase Analysis aspartate Aspartate aminotransferase base excess Bicarbonate Blood blood cell blood cell count C-reactive protein calcium carbon dioxide caused Cell changes changes in cholesterol cholinesterase Clinical characteristics clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 creatine creatine kinase cystatin C D-dimer death Degradation Degradation product determine diagnosed with COVID-19 distribution eosinophil Eosinophil count estimated glomerular filtration rate Extracellular Extracellular fluid FIBRIN filtration rate fluorescent fraction glomerular filtration rate Glucose Haemoglobin high risk High-density lipoprotein High-density lipoprotein cholesterol Hospitalized hypersensitive C-reactive protein immature Inpatient International international normalized ratio Laboratory Laboratory test Laboratory tests Lactate lactate dehydrogenase lipoprotein cholesterol lymphocyte Lymphocyte count Magnesium marker mean platelet volume Mild monocyte Myoglobin neutrophil neutrophil count nitrogen non-survivor Non-survivors normalized occurred ogen outbreak Patient patient condition phosphatase phosphorus plasma plasma urea Platelet Platelet count platelet distribution width prealbumin procalcitonin progression Protein prothrombin Prothrombin time red blood cell red blood cell count Result SARS-CoV − 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease significant difference significant differences significantly significantly increased sodium supplementary material survivor Temporal Temporal changes test results total calcium Total cholesterol total protein Treatment Triglyceride urea urea nitrogen uric acid variable variables Volume White blood cell white blood cell count width with COVID-19 Wuhan
[DOI] 10.1186/s12879-020-05678-0 PMC 바로가기 [Article Type] Comparative Study

Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study

COVID-19에 대한 수정 가능 및 수정 불가능 위험 요인 및 인플루엔자 및 폐렴 위험 요인과의 비교: UK Biobank 전향 코호트 연구 결과

Epidemiology

Published on 2020-11-192022-09-10
Journal: BMJ Open [Category] Fulltext, SARS, 바이오마커,

[키워드] association blood pressure body mass body mass index Cardiology cholesterol clinical risk factor Confirmed Confirmed COVID-19 infection COVID-19 COVID-19 infection cystatin C diabetes & endocrinology Epidemiology expiratory forced expiratory volume General population Haemoglobin HDL help high risk high-density High-density lipoprotein hypertension incident increase in index Influenza influenza and pneumonia less lower risk Male sex medication Modification multivariable objective outcome measure outcomes overlapped participant Participants physical physical fitness Pneumonia Poisson regression population study positive primary care prospective cohort study reduce Result risk factor Risk factors risk of COVID-19 SARS-CoV-2 test setting shielding smoking social distancing Socioeconomic deprivation UK biobank variable Volume was used
[DOI] 10.1136/bmjopen-2020-040402 PMC 바로가기 [Article Type] Epidemiology

Causal Inference for Genetic Obesity, Cardiometabolic Profile and COVID-19 Susceptibility: A Mendelian Randomization Study

유전적 비만, 심혈관 대사 프로필 및 COVID-19 감수성에 대한 인과 추론: 멘델식 무작위 배정 연구

Genetics

Published on 2020-11-112022-08-13
Journal: Frontiers in Genetics [Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association BMI body mass body mass index cardiometabolic cardiometabolic trait cardiometabolic traits category Causal cholesterol co-morbidity Cohort conducted confidence interval coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 Host Genetics Initiative COVID-19 infection Cox model Cox proportional hazard models European evaluate Genetic genetic risk genetic risk score genetic risk scores Genotype Glucose glycated hemoglobin hazard ratio HDL-cholesterol hemoglobin high-density High-density lipoprotein higher odd higher odds Hospitalization host genetics increased risk independent dataset independent datasets indicated individual Inference integration LDL LDL cholesterol lipid profile lipoprotein low-density Low-density lipoprotein mendelian randomization Modification morbidities MR analysis multivariable logistic regression obesity observational studies observational study Odds ratio parameter participant phenotype positive predictor present produced profile Quantitative reported respiratory Result risk Risk assessment risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity serum severe acute respiratory syndrome Coronavirus Standard deviation Support susceptibility Systolic blood pressure tested traits Treatment Triglyceride triglycerides UK biobank Waist circumference was performed
[DOI] 10.3389/fgene.2020.586308 PMC 바로가기 [Article Type] Genetics

Lipoprotein concentrations over time in the intensive care unit COVID-19 patients: Results from the ApoCOVID study

중환자실 COVID-19 환자의 시간 경과에 따른 지단백질 농도: ApoCOVID 연구 결과

Research Article

Published on 2020-09-242022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Admission Anti-inflammatory antioxidant association Bacterial Bacterial sepsis bacterial superinfection caused change cholesterol clearance Concentration conducted consecutive patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia dead patient decrease Diagnosis functions global pandemic HDL HDL-C HDLs High-density lipoprotein High-density lipoproteins Hospitalization Hospitalized ICU ICU admission ICU patient incidence increase in intensive care LDL cholesterol LDL-C lipopolysaccharides lipoprotein Lipoproteins Low-density lipoprotein low-density lipoproteins Mortality neutralize nonsurvivors outcome outcomes Particle Particles Patient pleiotropic Pneumonia profile Prospective Study reference values reported respiratory Result Sepsis Severe COVID-19 pneumonia statistically significant superinfection survival survivor Transport university hospital VAP Ventilator-associated pneumonia were assessed
[DOI] 10.1371/journal.pone.0239573 PMC 바로가기 [Article Type] Research Article