Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria ImmunosuppressionArticle Published on 2023-06-162024-08-29 Journal: International Journal of Molecular Sciences [Category] 말라리아, [키워드] 4-hydroxynonenal 4-HNE CYP4F11 cytochrome P450 human monocytes hydroxyeicosatetraenoic acids HETEs lipoperoxidation malaria
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Characterization of methylation patterns associated with lifestyle factors and vitamin D supplementation in a healthy elderly cohort from Southwest Sweden Research Published on 2022-07-252022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] activated Affect age Analysis Cancer changes in characterization Cohort Combination deficiency DNA DNA methylation Effect EpiC Epigenetic expression Factor Factors Genome Health healthy healthy individual human monocytes Illumina IMPROVE individual investigated involved knowledge marker medication Mental Methylation molecular Numerous occur Older pathway Pathways performed physical activity Prevalence Regulation shown SLC25A24 study cohort study participant Treatment Vitamin D Vitamin D receptor Vitamin D supplementation Wnt pathway [DOI] 10.1038/s41598-022-15924-x [Article Type] Research
The SARS-CoV-2 Nucleoprotein Induces Innate Memory in Human MonocytesSARS-CoV-2 핵단백질은 인간 단핵구에서 선천적 기억을 유도합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, [키워드] Anti-inflammatory Bacterial COVID-19 Cytokines effector cells heat-inactivated virus Human immune system human monocyte human monocytes in vitro induce Infection infections Innate Innate immunity innate memory Interaction macrophages memory monocyte Monocytes N protein nucleocapsid nucleoprotein outcome phenomenon positive Protein Protein subunit reaction reactivity S1 and S2 SARS-CoV-2 Spike protein subsequent tested the Spike virus [DOI] 10.3389/fimmu.2022.963627 PMC 바로가기 [Article Type] Article
The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3SARS-CoV-2 스파이크 단백질의 S1 서브유닛은 인간 단핵구를 활성화하여 COVID-19와 연결된 사이토카인을 생성합니다: 갈렉틴-3과의 관련성Article Published on 2022-03-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS basophil basophils bind caused component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRS cytokine Cytokine release syndrome Cytokines dendritic dendritic cell disease dysregulated Efficacy epithelial cell epithelial cells Evidence facilitate feature fold galectin-3 Health human monocyte human monocytes immune cells Inflammation innate immune innate immune cell Innate immune cells innate immune response Innate immunity lectin Lung injury mechanism MERS Middle East Middle East respiratory syndrome monocyte Monocytes N-terminal domain novel vaccines NTD pandemic persistence pocket Produce Relevance reported respiratory respiratory distress Respiratory distress syndrome responsible S1 subunit S1-NTD S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus shown solid phase spike Spike protein stalk structural homology susceptible individuals syndrome synthesis the S1 subunit the SARS-CoV-2 the spike protein therapeutic interventions Therapeutics Vaccine variants virus while β-Coronaviruses [DOI] 10.3389/fimmu.2022.831763 PMC 바로가기 [Article Type] Article
HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes420 Published on 2021-06-292022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] activate activated acute respiratory syndrome affected alarmin antibody Blood Cell clinical conditions coronavirus COVID-19 COVID-19 infection epithelial cells expression Factors favor function HIF-1α HIF-1α HMGB1 human monocytes hypoxia hypoxic hypoxic conditions IFN implication induce Infection Inflammatory cytokine interferon interferon regulatory factor investigated IRF3 IRF5 microenvironment monocyte Monocyte activation Monocytes Necrosis normoxic nuclear oxygen pathogenesis of COVID-19 pathophysiology produced Proinflammatory cytokine proinflammatory cytokines Regulatory released secretion Severe COVID-19 Infection shown Significance stressed cells suppresse tissue transcriptional transcriptional repressor Type I IFN type I interferon [DOI] 10.1073/pnas.2106017118 PMC 바로가기 [Article Type] 420
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytesArticle Published on 2021-03-012022-10-04 Journal: Cell Death Discovery [Category] 치료제, [키워드] 2019 coronavirus disease Activation acute respiratory syndrome caspase-1 cellular component cleavage coronavirus COVID-19 critically ill patients death engage gasdermin D human monocytes hyper-inflammation IL-1ß Inflammasome Inflammatory response intensive care leukopenia mechanism monocyte Monocytes Patient Peripheral blood pro-inflammatory cytokine pyroptosis recruited reduce viral replication respiratory tract SARS-CoV-2 severe COVID-19 therapy Trigger viral infection [DOI] 10.1038/s41420-021-00428-w PMC 바로가기 [Article Type] Article
VISTA: A Target to Manage the Innate Cytokine StormVISTA: 타고난 사이토카인 폭풍을 관리하기 위한 표적Review Published on 2021-02-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] agonistic antibodies Anti-inflammatory Antigen presentation Autoimmune diseases blockade Cancer canonical marker canonical markers CD14 CD16 Cell change Complete conserved COVID-19 cytokine Cytokine storm Cytokine storms Diseases driven by dysregulated immune response expression Fcγr3a focus highlight human monocyte human monocytes Hyperinflammatory response IFN-I immune immune checkpoint immune responses immune system Immunity Immunosuppression Immunotherapy implication Inflammatory responses inhibitory Innate monocyte reprogramming Monocytes myeloid myeloid cell myeloid cells offer pathogenic pathology pathway Pathways phenotype receptor related diseases storm Support suppress T cell T cell activation target the interferon therapeutic triggering unique Viral viral infection viral infections vista while [DOI] 10.3389/fimmu.2020.595950 PMC 바로가기 [Article Type] Review
Recombinant SARS-CoV-2 Spike Protein Mediates Glycolytic and Inflammatory Activation in Human MonocytesAbstracts Published on 2020-12-162022-10-30 Journal: Innovation in Aging [Category] COVID-19, [키워드] ACE2 receptor activate Activation acute respiratory syndrome cause caused cell lysate Contamination coronavirus disease Coronavirus-2 COVID-19 cytokine production Cytokine storm Donor Efficacy ELISA endotoxin Evidence Extracellular facilitate Glycolysis healthy human monocyte human monocytes Immune cell increase in Inflammation Inflammatory Inflammatory response Interaction interleukin-6 investigated marrow-derived macrophage metabolic monocyte mouse processed Protein protein expression qPCR Rapamycin recombinant SARS-CoV-2 SARS-CoV-2 spike protein Seahorse spike stimulated subunit the spike protein treating COVID-19 upregulation [DOI] 10.1093/geroni/igaa057.3493 PMC 바로가기 [Article Type] Abstracts
Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokinesPhysical Sciences Published on 2020-11-032022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome antigenic Antiviral binding caused Cell cell membrane cell membrane vesicle cells cellular membrane competing coronavirus COVID-19 COVID-19 pandemic cytokine cytokine receptor Cytokine storm death decoy develop drugs effective intervention effective vaccine enzyme II Epidemics Express expressing exterior fusing GM-CSF host cell host cells human monocyte human monocytes IL-6 immune disorder Infection Inflammatory cytokine Lung injury nanodecoy neutralization neutralize Pneumonia presenting PROTECT pseudovirus receptors robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Significance significantly specific treatment suppress therapeutic strategy Vaccine viral infection virus Virus neutralization [DOI] 10.1073/pnas.2014352117 PMC 바로가기 [Article Type] Physical Sciences