MCP-1, monocyte chemoattractant protein 1

[키워드] accompanied ACE2, angiotensin-converting enzyme II Activation acute respiratory distress acute respiratory syndrome ADAM17, metalloprotease 17 alarmin ALI, acute lung injuries approach AT1R, activation of angiotensin-1-receptor BAFFR, B-cell activating factor receptor BLC, B-lymphocyte chemoattractant bortezomib c-AMP, cyclic adenosine phosphate CASP3, caspase 3 CCL, chemokine ligand CD40⁺, cluster of differentiation 40 CDC, Center for Disease Control and Prevention chemokine coronavirus disease Coronavirus-2 Corticosteroid cough CoV, coronavirus COVID-19 COVID-19, Coronavirus disease 2019 COX-2, cyclooxygenase-2 cross-talk CRP C, reactive protein CTLs, cytotoxic T lymphocytes CXCL C-X-C, motif chemokine ligand CXCL, C-X-C- motif chemokine cytokine Cytokine storm Cytokine storm syndrome DAMP, damage-associated molecular patterns (DAMP) demonstrated Dexamethasone Diseases Dyspnoea dysregulated Effectiveness Enzymes ERK1/2, extracellular signal-regulated kinases expression feature Fever GSDMD, Gasdermin highlight Host Host immune response IKK, IκB kinase IL-1R, Interleukin 1 receptor (IL-1R) IL, interleukin immune dysregulation immune system Inflammation Inflammatory cytokine inhibitor iNOS, nitric oxide synthase IP-10, interferon-inducible protein 10 JAK, Janus kinase JNK, Jun amino-terminal kinases life-threatening LPS, lipopolysaccharides LTβR, Lymphotoxin-β receptor manifestation MAPK, Mitogen-activated protein kinase MAPKs, mitogen-activated protein kinases MCP-1, monocyte chemoattractant protein 1 MIG, monokine induced by interferon-γ MIP-1α and MIP-1β, macrophage inflammatory protein 1α and 1β, respectively monoclonal antibody morbidity and mortality multiple organ failure NEMO, regulatory subunit IKKγ NF-κB NF-κB, nuclear factor kappa B cells NF-κB NK, natural killer NO, Nitric Oxide Novel coronavirus nucleotide offer PAMPs, pathogen-associated molecular patterns pathway PKR, threonine-derived kinases pro-inflammatory mediators PTMs, post-translational modifications RANK, receptor activator of NF-κB Remdesivir responsible RSV, respiratory syncytial virus SARS-CoV-2 SARS, Severe acute respiratory syndrome Septic shock Severe acute respiratory syndrome severe complication severe COVID-19 patients Signal transduction significant decrease SMD, SOD, superoxide dismutase STAT3, signal transduction activator of transcription factor 3 STING, stimulator of interferon genes syndrome systemic inflammation Th, helper T cells therapeutic intervention therapeutic strategy therapy TLR-4, Toll-like receptor-4 TNF-α TNF, Tumour Necrosis Factor TNFR, tumour necrosis factor receptor tyrosine upregulating VEGF, Vascular endothelial growth factor
[DOI] 10.1016/j.intimp.2021.108255 PMC 바로가기 [Article Type] Article