Beneficial effects of recombinant CER-001 high-density lipoprotein infusion in sepsis: results from a bench to bedside translational research projectarticle Published on 2023-11-022024-09-05 Journal: BMC Medicine [Category] update2024, [키워드] ApoA-I complexes Cytokine storm multi-organ dysfunction Sepsis [DOI] 10.1186/s12916-023-03057-5 PMC 바로가기 [Article Type] article
Single-Cell Transcriptome Analysis Reveals the Role of Pancreatic Secretome in COVID-19 Associated Multi-organ DysfunctionsArticle Published on 2022-12-012023-07-08 Journal: Interdisciplinary sciences, computational life sci [Category] COVID19(2023년), [키워드] COVID-19 multi-organ dysfunction pancreas SARS-CoV-2 Single-cell transcriptomics [DOI] 10.1007/s12539-022-00513-3 PMC 바로가기
Human genetic basis of severe or critical illness in COVID-19Article Published on 2022-09-202022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome affecting association Asymptomatic base caused contribute coronavirus COVID-19 Critical Critical illness death determinant disease disease severity enhanced Enzymes Factor Genetic Genetic variation genetic. Host Human human leukocyte antigen immune component indicated Interaction Interleukins loci mild infection morbidity and mortality multi-organ dysfunction outcome Precision preventive measure Respiratory failure SARS-CoV-2 SARS-CoV-2 receptor Serine severity of COVID-19 Toll-like receptor transmembrane [DOI] 10.3389/fcimb.2022.963239 PMC 바로가기
Interleukin 6: A biomarker for COVID-19 progressionResearch article Published on 2022-08-022022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 바이오마커, 신약개발, 임상, 치료제, [키워드] “cytokine storm” Biomarker caused China clinical trial Concentration COVID COVID-19 COVID-19 progression CRS cytokine Cytokine release syndrome Cytokine storm Diagnosis disease Health highlight IL-6 IL-6 level immune system immunoregulation Infection Inflammation inhibited interleukin interleukin-6 massive inflammatory monoclonal antibodies monoclonal antibody morbidity and mortality multi-organ dysfunction pandemic Patient pleiotropic pro-inflammatory cytokines progression receptor reduce reducing Respiratory failure resulting SARS-CoV-2 serum severe complications severity of COVID-19 significantly therapeutic target through contact transmitted Treatment World Health Organization zoonotic [DOI] 10.1016/j.matpr.2022.07.387 [Article Type] Research article
Detection of Echovirus-18 in Children Suspected With SARS-CoV-2 Infection With Multisystem Inflammatory Syndrome: A Case Report From India다기관 염증 증후군이 있는 SARS-CoV-2 감염이 의심되는 어린이에서 Echovirus-18 검출: 인도의 사례 보고Case Reports Published on 2022-07-222022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] Adults age Analysis Bacterial children COVID-19 detection Diagnosis diarrhea echovirus Echovirus-18 effective enterovirus globe Hyperinflammatory syndrome India Inflammatory investigated Kawasaki disease less management MIS-C molecular analysis multi-organ dysfunction oropharyngeal swab oropharyngeal swabs pandemic pathophysiology patients pediatric Pediatric patients performed report Respiratory system SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 testing Stool Suspected Symptom syndrome the SARS-CoV-2 viral infection were infected [DOI] 10.3389/fpubh.2022.897662 PMC 바로가기 [Article Type] Case Reports
Recent Progress in the Development of Opaganib for the Treatment of Covid-19Covid-19 치료를 위한 Opaganib 개발의 최근 진행 상황Review Published on 2022-07-122022-09-11 Journal: Drug design, development and therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] ABC294640 acceleration active against Administered Anti-SARS-CoV-2 Activity Antiviral antiviral activity biochemical Cancer clearance clinical trial COVID-19 pandemic decrease demonstrated development dihydroceramide desaturase disease driven by drug enzyme glucosylceramide glucosylceramide synthase Host Infection Inflammation Inflammatory diseases inhibit inhibiting mechanism metabolism Mild Mild disease moderate moderately severe COVID-19 modulation Mortality multi-organ dysfunction opaganib pandemic pathologic pathologic processes Patient patients patients hospitalized phase Progress recent regulate Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 virus Signaling sphingolipid sphingolipids sphingosine sphingosine kinase. Stress subpopulation suppresse the SARS-CoV-2 virus treat Treatment treatment protocols understanding viral proliferation virus [DOI] 10.2147/DDDT.S367612 PMC 바로가기 [Article Type] Review
Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patientsRandomized Controlled Trial Published on 2022-02-142022-10-04 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 Abstract Administered administration affected approved caused Central nervous system Clinical improvement clinical trial CNS concentrations conducted COVID-19 COVID-19 patient Critical death defined Dexamethasone dose doses dysregulated Effectiveness Efficacy FIVE Glucocorticoids group health institution Hospitalization IMPROVE individual Inflammation intranasal intranasal administration intranasally intravenous intravenously low dose Mexico City moderate multi-organ dysfunction multicenter Neuroinflammation Open-label Patient patients Primary outcome protocol Randomized Randomized controlled trial recruited reduce reduce mortality reduction in mortality regimen respiratory tract secondary outcome severe COVID-19 severe COVID-19 patients statistically significant reduction systemic inflammation therapeutic therapeutic dose treated triggering two group [DOI] 10.1186/s13063-022-06075-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Sequential Organ Failure Assessment Outperforms Quantitative Chest CT Imaging Parameters for Mortality Prediction in COVID-19 ARDSArticle Published on 2021-12-222022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome Admission ARDS ARDS patient artificial intelligence assessment association AUC Chest Chest CT computed tomography scan COVID-19 COVID-19 disease COVID-19 patients Critically ill patient diagnostic diagnostic value evaluated failure high mortality ICU ICU admission imaging in-hospital mortality include Injury intensive care lung Lung compliance Lung injury lung involvement management mask ventilation mechanical ventilation moderate multi-organ dysfunction multi-organ failure Organ failure Oxygenation oxygenation index parameter Patient patient triage positive airway pressure predict prediction Predictive pulmonary hypertension resource resources respiratory insufficiency Retrospective study risk stratification ROC analysis severe ARDS Severity Score significantly single center SOFA SOFA score syndrome vessel were assessed [DOI] 10.3390/diagnostics12010010 PMC 바로가기 [Article Type] Article
Corona Virus Disease 2019 (COVID-19) as a System-Level Infectious Disease With Distinct Sex Disparities2019년 코로나 바이러스 질병(COVID-19)은 성별 격차가 뚜렷한 시스템 수준 전염병Review Published on 2021-11-292022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] abnormality ACE2 acute respiratory syndrome coronavirus Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 clotting system Coagulation Corona coronavirus COVID COVID-19 cytokine Cytokine storm Cytokine storms disparity endothelial cells endotheliopathy Endothelium explain expressed fatigue global pandemic heart help host cells hyper-inflammation hypercoagulability Immune cell immune cells immune system Immunity increased the risk interconnectedness kidney lead lung men Mortality multi-organ dysfunction neurons outcome physical physical fitness RAS recruitment reduced Renin renin-angiotensin system respiratory resulting SARS-CoV-2 SARS-CoV-2 entry severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Sex Symptoms System Thromboembolism thrombosis Venous thrombosis [DOI] 10.3389/fimmu.2021.778913 PMC 바로가기 [Article Type] Review
Bilateral basal ganglia ischemia associated with COVID-19: a case report and review of the literatureCase Report Published on 2021-11-222022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Asian Asymptomatic Bilateral Brain caused Confusion coronavirus coronavirus disease Coronavirus disease 2019 cough Effect effective event Fever ganglia Infection Ischemia lower limb management multi-organ dysfunction Neuroimaging neurological sign NEUROLOGY Pain Patient prothrombotic state radiology reported SARS-CoV-2 Shortness of breath [DOI] 10.1186/s13256-021-03165-x PMC 바로가기 [Article Type] Case Report