Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Intensive care medicine [Category] Fulltext, MERS, 바이오마커, [키워드] ABO-compatible convalescent plasma Adaptive platform trial Adults Analysis assigned Biomarker Biomarkers chemokines community-acquired pneumonia convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill patients Cytokines difference effector immune responses elevated endothelial explain heterogeneous homogeneous Hypothesis immunologically immunotherapies Inflammation IQR median multifactorial organ support outcome outcomes patients Population precision medicine Prevalence Randomized randomized clinical trial RCT RCTs REMAP-CAP reported secondary analysis Subphenotypes. tested therapy treatment effect Treatment response usual care with COVID-19 [DOI] 10.1007/s00134-022-06869-w PMC 바로가기
Randomized, Double-Blind, Placebo-Controlled Trial of a Throat Spray with Selected Lactobacilli in COVID-19 OutpatientsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acting acute respiratory syndrome added Administered administration Amplicon sequencing analyses Analysis antibody Antiviral antiviral property antiviral strategy applied Bacteria benefit Care chills collected Combined coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients detectable Diagnosis diarrhea double-blind dried blood spot eligible evaluated Fever Health hospital Hospitalization infected with SARS-CoV-2 Lactobacillaceae lactobacilli Microbiome modulation multifactorial nasopharyngeal viral load nose-throat swab online questionnaire Outpatient Pain Patient per-protocol analysis Placebo placebo-controlled trial positive potential mechanism practitioners qPCR quantitative PCR Randomized reduce reducing reported reported symptom respiratory tract infection respiratory viral disease SARS-CoV-2 selected sequence severity significantly spray strain Symptom symptom resolution the patient the placebo group therapy Throat throat spray. Treatment Trial trials upper respiratory tract Vaccines variant Viral diseases viral infection Viral load was performed [DOI] 10.1128/spectrum.01682-22 PMC 바로가기
Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian familiesArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome addition Analysis association carried characterized clinical expression Clinical outcome clinical variability coronavirus COVID-19 determine disease genetic background genetic profile heterogeneity Host host response Immunity Infection Interaction involved Italian multifactorial occurred outcome performed Perspective phenotype positive protective effect rare variant risk SARS-CoV-2 shown SNPs statistical analysis statistically significant subject susceptibility the disease Transmission Transmission dynamics Vaccine Variability variant viral infection virus virus entry [DOI] 10.1371/journal.pone.0275988 PMC 바로가기
Long Covid: where we stand and challenges aheadArticle Published on 2022-10-012022-11-15 Journal: Cell Death and Differentiation [Category] COVID19(2023년), SARS, 진단, [키워드] addition Affect Autoimmunity Brain Breakthrough infection cardiovascular system complex defined disease driver EBV Health care system Inflammation initial kidney Long Lungs manifestation mechanism multifactorial organ organs other organ PASC Pathogenesis pathway persistence reduce SARS-CoV-2 SARS-COV-2 infection Symptom therapeutic approaches tissue vaccination virus [DOI] 10.1038/s41418-022-01052-6 PMC 바로가기
Coagulation parameters predict COVID-19-related thrombosis in a neural network with a positive predictive value of 98Article Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] age C-reactive protein changes in clinical complication coagulation factor Coagulation system Cohort complexes complicate COVID-19 COVID-19 infection COVID-19 patient hospital Hospital admission ICU admission IgM Laboratory multifactorial neural net Neural network parameter pathogenesis of COVID-19 Patient patients Positive predictive value predict prediction serum Sex suffered thrombin Thrombin generation thrombosis thrombotic event variable [DOI] 10.3389/fimmu.2022.977443 PMC 바로가기
SARS-CoV-2 induced hepatic injuries and liver complicationsArticle Published on 2022-09-162022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 진단, 치료기술, [키워드] abnormality acute respiratory syndrome ADE Affect Antibody-dependent enhancement Case fatality rate caused clinician Comorbidity Complication Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 patient demonstrated detectable diabetes disease Effect Fecal sample gastrointestinal tract globe HCC hepatic dysfunction hepatic injury hepatocellular Hepatocellular carcinoma hepatocyte highly pathogenic hypertension hypoxia identification Immunopathogenesis in vitro in vivo Infection investigated involved Ischemia liver Liver damage Liver injury mechanism mechanism of liver damage. molecular mechanism multifactorial Patient Psychological reported Research Respiratory samples rising RNA RT-PCR SARS-CoV-2 signaling pathways significantly Stress systemic inflammation Toxicity [DOI] 10.3389/fcimb.2022.726263 PMC 바로가기
Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infectionArticle Published on 2022-09-022022-11-16 Journal: PLoS Pathogens [Category] 유전자 메커니즘, [키워드] Acinetobacter acquisition antimicrobial drug Bacteremia Bacterial bloodstream infection caused change characteristic COVID-19 pandemic Critical curtail dissemination essential nutrient evaluated exhibited expand expression expression pattern feasible gene encoding Gene Expression Gram-negative bacteremia growth Health healthcare homeostasis Host host gene expression Immunity impairment include induce Infection inhibit inhibiting innate immune response involved lack Lcn2 lipocalin-2 MDR mechanism mice Mortality multidrug resistant multifactorial organ organ-specific pathogen Pneumonia Prevalence proliferation Protective Protein required reveal robust S100A8 S100A9 secondary bacterial pneumonia sequestering survival target therapeutic tissues Transcription transcriptional Treatment upregulated ventilated patient Ventilator-associated pneumonia were infected World Health Organization [DOI] 10.1371/journal.ppat.1010809 PMC 바로가기
Phylogenomic analysis of the monkeypox virus (MPXV) 2022 outbreak: Emergence of a novel viral lineage?Article Published on 2022-09-012022-11-15 Journal: Travel medicine and infectious disease [Category] 진단, [키워드] affecting Analysis B.1 B.1 lineage characterized clade clinical manifestation community transmission confirmed case COVID-19 pandemic demonstrated determine driver emergence epidemiological Europe Evolution exceptional Factor generate Genome genomic globe help humans include information lineage B.1 measure mitigate Monkeypox Monkeypox virus multifactorial outbreak pathogen performed Phylogenomic analysis public health Region reported resource Spread Surveillance sustained Transmission dynamics unique vaccination virus zoonotic disease [DOI] 10.1016/j.tmaid.2022.102402 PMC 바로가기
An unusual presentation of recurrent COVID-19 associated systemic capillary leak syndrome in a patient with multi-system inflammatory syndrome in adults (MIS-A) due to prior COVID-19 infection: Case report and literature reviewCase report Published on 2022-09-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 진단, [키워드] Asian body aches Capillary leak capillary leak syndrome Case report clinical complex disorders condition cough COVID-19 COVID-19 infection diagnosed disorder Dizziness etiology Fever increased risk Infection Inflammatory inflammatory complication inflammatory state information knowledge Laboratory less literature review manifestation manifested Measures MIS-A multifactorial Multisystem inflammation Pain pathophysiology Patient Recurrent reported resources SCLS Shortness of breath syndrome systemic the patient thought with COVID-19 [DOI] 10.1016/j.amsu.2022.104309 [Article Type] Case report
Novel aspects of sepsis pathophysiology: NETs, plasma glycoproteins, endotheliopathy and COVID-19Review article Published on 2022-09-012022-10-05 Journal: Journal of pharmacological sciences [Category] 바이오마커, [키워드] accumulating acute phase addition ARDS Blood cells cascade caused Coagulation complex COVID-19 defined develop drug dysregulated effective therapy endotheliopathy Evidence functional glycoprotein Health Health Organization Histidine-rich glycoprotein (HRG) host response HRG Infection life-threatening multifactorial NET NETs Neutrophil extracellular trap neutrophil extracellular traps (NETs) novel organ dysfunction organs pathophysiology plasma plasma protein problem Protein Proteins Regulation Sepsis targets vascular endothelial cell [DOI] 10.1016/j.jphs.2022.06.001 [Article Type] Review article