Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine StimulationDiscovery Proteomics 분석을 통해 드라이버 종양유전자가 인터페론-β 자가분비 자극 감소를 통해 항바이러스 방어 경로를 억제한다는 사실이 확인되었습니다.Article Published on 2022-07-012022-09-11 Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activated AKT Antiviral approach autocrine BRAF c-MYC Cancer cancer cell line cancer cell lines cancers Cell cell line cellular DDX58 develop double-stranded double-stranded RNA downregulation driven by driving dsRNA EGFR expression functional hallmark HER2 immune evasion Infection interferon KRAS lower expression MEK molecular MYC OAS oncogene oncogenes. oncogenic osteosarcoma Pancreatic cancer phenotypic profiles Protein Proteins proteome provide reduced regulated response RIG-I RNA virus SARS-CoV-2 shown Stimulation susceptibility susceptibility to infection therapeutic treated type 1 interferon [DOI] 10.1016/j.mcpro.2022.100247 PMC 바로가기 [Article Type] Article
WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinomaArticle Published on 2022-03-092022-10-04 Journal: Cell Death Discovery [Category] 바이오마커, [키워드] Bile duct cancer Biological functions CCK-8 Cell Cholangiocarcinoma chromatin immunoprecipitation Clinical prognosis correlated detect Effect expressed expression expression pattern facilitate Hepatocellular carcinoma ICC IHC immunofluorescence immunohistochemistry intrahepatic investigated Mechanisms of disease Metastasis molecular mechanism MYC NDFIP1 Oncogenes overexpression Patient performed poor prognosis potential mechanisms potential therapeutic target predict progression proliferation promote promoter region Protein protein level reduce reported rescued reveal target tissue tissues Transwell tumor progression Ubiquitylation upregulated upregulation were used WWP1 [DOI] 10.1038/s41420-022-00882-0 PMC 바로가기 [Article Type] Article
Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico AnalysisArticle Published on 2021-11-292022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] Altered coded coding gene COVID-19 COVID-19 patients CRISPR deregulated deregulation expression Factor functional Gene Expression IFN treatment interferon IRFs joint lncRNA Long long non-coding RNA majority manuscript mechanism modulate modulated MYC NFκB over pathogenesis of COVID-19 pathway Pathways PCG Protein Proteins Regulation resources RNA SARS-CoV-2 SARS-CoV-2 infected cell SARS-COV-2 infection significantly STATs target TFS tissue Transcription transcription factor transcription factors transcriptional regulation [DOI] 10.3390/ncrna7040074 PMC 바로가기 [Article Type] Article
Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approachesCOVID-19에 대한 잠재적 약물 표적 및 후보 약물 식별: 생물학적 네트워크 및 구조 모델링 접근법Research Article Published on 2021-05-172022-08-31 Journal: F1000Research [Category] MERS, 치료기술, 치료제, [키워드] acute respiratory syndrome addition Algorithm Analysis Antigen antigen processing approach BCL3 binding affinity Biological network analysis Biomarker Biomarkers candidate drug candidate drugs CBL CEBPB complex conducted coronavirus CoV CoV infection COVID-19 CRKL cytokine demonstrated docking result drug target drug targets ERBB4 expressed expression expression profile expression profiles facilitate flexibility growth factor growth factor receptor binding HDAC9 host cell host gene host immune system human pathogen identifying immune signaling pathway include indicated inhibit innate immune response interleukin interleukin-1 KLHL12 Limma macropinocytosis MAPK MAPK signaling medicated MHC class I modulation module molecular dynamics Molecular dynamics simulation molecular dynamics simulations mortality rate MYC NCOA3 network analysis pathway Pathways peptide PPI PPI network protein-protein docking protein-protein interaction receptor Receptor binding receptor signaling reduce regulate Replication respiratory Respiratory system retrieved SARS-CoV-2 SARS-CoV-2 pathogenesis selected Severe acute respiratory syndrome Signal transduction signal transduction pathways Signaling signaling pathways Smad3 SMURF1 stability stimulatory T cell T cell receptor tyrosine VEGFA Walktrap algorithm was selected wortmannin [DOI] 10.12688/f1000research.50850.3 PMC 바로가기 [Article Type] Research Article
TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patientsResearch Published on 2020-09-232022-10-29 Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor Analysis binding cancer patient Cancer patients cells conducted COVID19 database dataset downregulated elevated expression frailty help HNSCC host cell HPV independent inherent lung cancer lung tissue men Methylation microRNA microRNAs TP53 mutated MYC observation Patient positive promoter protease Protein reduced Result S priming SARS-CoV-2 SARS-COV-2 infection significantly statistically significant subsequent the Spike tissue tissues TMPRSS2 TMPRSS2 expression TMPRSS2 protease TP53 tumors variable women [DOI] 10.1186/s13046-020-01708-6 PMC 바로가기 [Article Type] Research
miR-451 limits CD4+ T cell proliferative responses to infection in micearticle Published on 2017-08-312024-09-01 Journal: Immunologic Research [Category] 말라리아, [키워드] malaria miRNA MYC proliferation T cell [Article Type] article