post-translational modifications – Communicable Diseases Research

Alzheimer’s-like signaling in brains of COVID-19 patients

COVID-19 환자의 뇌에서 알츠하이머와 유사한 신호

Article

Published on 2022-05-012022-09-11
Journal: Alzheimer's & dementia : the journal of the Alzhei
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue

지방 조직의 크레아틴 키나아제 상향 조절과 관련된 척수 손상 환자의 욕창 수술 후 코로나바이러스 후 합병증

Article

Published on 2022-04-092022-09-11
Journal: Cells
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] adipose Adipose tissue analyzed Associate autoantibodies autoantibody Biomarker CKM CKMT2 CKs Complication complications CORD correlation Covid patients COVID-19 COVID-19 diagnosis COVID-19 pandemic creatine Diagnosis identify Infection Inflammatory response Injury kinase mechanism MGCs Patient patients patients with SARS-CoV-2 post-translational modification post-translational modifications postoperative Postoperative Complications Predictive pressure pressure ulcer pressure ulcers progression Protein proteomic proteomics PU reconstructive surgery Registered risk SARS-CoV-2 SARS-COV-2 infection SCI serum significantly increased spinal spinal cord Spinal cord injury surgery surgery. Surgical Procedure tissue ulcer underlie upregulated
[DOI] 10.3390/cells11081282 PMC 바로가기 [Article Type] Article

Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity

감소된 감염성과 함께 약독화된 바이러스의 방출을 초래하는 SARS-CoV-2 스파이크 팔미토일화 억제제의 식별

Article

Published on 2022-03-042022-09-11
Journal: Viruses
[Category] SARS, 변종,

[키워드] acylation Antiviral antivirals biogenesis bis-piperazine C-terminal cysteine cysteine residue cytoplasmic DHHC9 domain ER and Golgi FIVE fusion Glycoproteins Golgi identification Infection Infectivity inhibit SARS-CoV-2 inhibitor interact Intervention knockdown membrane fusion palmitate palmitoylation palmitoyltransferase palmitoyltransferase inhibitor Particle piperazine post-translational modifications progeny virion Protein reduced Release released Result resulting S protein S-acylation SARS-CoV-2 SARS-CoV-2 S protein spike Spike mutant Spike protein Spike proteins Spike. the SARS-CoV-2 the spike protein transmembrane glycoprotein undergo virus virus
[DOI] 10.3390/v14030531 PMC 바로가기 [Article Type] Article

The 2022 Nucleic Acids Research database issue and the online molecular biology database collection

AcademicSubjects/SCI00010

Published on 2022-01-072022-10-31
Journal: Nucleic Acids Research
[Category] COVID-19, SARS,

[키워드] acid article Atla Biology CAZy Collection ConsensusPathDB COVID-19 database described Genomics Human include issue Major manuscript metabolism microbial Molecular biology New notable nucleic acid post-translational modifications Protein Proteins resource resources SARS-CoV-2 Structure target UCSC Genome Browser viral genome website
[DOI] 10.1093/nar/gkab1195 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010

Morphological Alterations and Stress Protein Variations in Lung Biopsies Obtained from Autopsies of COVID-19 Subjects

COVID-19 피험자의 부검에서 얻은 폐 생검의 형태학적 변화 및 스트레스 단백질 변이

Article

Published on 2021-11-122022-09-12
Journal: Cells
[Category] MERS, SARS, 진단,

Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion

Research Article

Published on 2021-08-312022-10-31
Journal: eLife
[Category] COVID-19, MERS, SARS,

[키워드] absence acute respiratory syndrome Analysis Cell conformational conformational change conformations contagious control cell coronavirus COVID-19 Critical described endpoints energy landscapes fusion peptide glycan glycans glycosylation Host host cell induce Infection initial Invasion lack membrane membrane fusion pathogen post-translational modifications postfusion prefusion Protein provide regulate released remained reported reveal SARS-CoV-2 spike steric structural framework Structure the Spike transmembrane Transmission Vaccine viral genome viral particle virus was used while
[DOI] 10.7554/eLife.70362 PMC 바로가기 [Article Type] Research Article

Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutants

Review

Published on 2021-08-122022-11-01
Journal: Clinical Proteomics
[Category] COVID-19,

[키워드] acute respiratory syndrome anti-viral antibody assays Betacoronavirus clinical study Combination continuous monitoring coronavirus coronavirus disease COVID-19 cross-reactivity diagnostic Diseases Emerging mutations evaluate facilitate functional identify Immunity immunoassays immunoprecipitation information knowledge mass mass spectrometry molecular diagnostics mutant mutations pandemic Pandemics Perspective Population post-translational modifications Protein protein–protein interactions proteomic proteomics quantification rapid response Research RNA sequencing RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus sensitivity Serology diagnostics serology test specificity targeted proteomics translational Viral protein Viral RNA viruses while
[DOI] 10.1186/s12014-021-09325-x PMC 바로가기 [Article Type] Review

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

Article

Published on 2021-06-232022-10-04
Journal: Nature Communications
[Category] 신약개발, 치료제,

Proteomics-Based Insights Into the SARS-CoV-2–Mediated COVID-19 Pandemic: A Review of the First Year of Research

SARS-CoV-2 매개 COVID-19 팬데믹에 대한 Proteomics 기반 통찰력: 연구 첫해에 대한 검토

Review

Published on 2021-06-042022-09-10
Journal: Molecular & Cellular Proteomics : MCP
[Category] MERS, 바이오마커, 비임상, 유전자 메커니즘,

[키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody article Betacoronavirus biological system Biomarker Biomarkers caused China CK2, casein kinase II Community coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19, Coronavirus disease 2019 DDA, data-dependent acquisition death develop Diagnosis effort evidenced Factor feature focus Genome genome sequence glycome glycosylation Health help Host host cell host response human disease immune system Infection information initial insight Interaction MS NSP, nonstructural protein pandemic peer-reviewed Perspective PIKFyve, a FYVE finger–containing phosphoinositide kinase post-translational modification post-translational modifications PPI, protein–protein interaction PRM, parallel reaction monitoring probe Protein–protein interaction protein–protein interactions proteome proteomic proteomic study proteomics provide PTM, post-translational modification qPCR, quantitative PCR Qualitative Quantitative respiratory responses review robust SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 selected severe acute respiratory syndrome Coronavirus the disease Therapies tissue TMPRSS2, Transmembrane serine protease 2 TMT, tandem mass tag Transmissibility Viral viral infection virulence virus worldwide pandemic Year
[DOI] 10.1016/j.mcpro.2021.100103 PMC 바로가기 [Article Type] Review

Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication

Article

Published on 2021-05-242022-10-04
Journal: Cell Discovery
[Category] 신약개발, 치료제,