signaling pathways
[대역어] None
[용어속성] Term
[용어속성] Term
SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variant
Article
[키워드] Activation
analyzed
antiviral response
arising
Beta
Calu-3 cell
calu-3 cells
cellular
circumvent
comparable replication
correlated
COVID-19 infection
Delta
Effect
epithelial
Evolution
genomic
host cell
human lung
Immunity
induce
innate immune
innate immune activation
Innate immunity
interferon
interferon response
ISG
ISGs
mRNA expression
Mutation
mutations
omicron
pandemic
produced
Replication
replication efficiency
SARS-CoV-2
SARS-CoV-2 variant
signaling pathways
STAT2
stimulated
Transmission
Treatment
vaccination
Vaccine
variant
variants
variants of concern
variants.
variations
Viral RNA
virus
virus replication
while
[DOI] 10.3389/fimmu.2022.1016108 PMC 바로가기
[DOI] 10.3389/fimmu.2022.1016108 PMC 바로가기
Comparison of Intracellular Transcriptional Response of NHBE Cells to Infection with SARS-CoV-2 Washington and New York Strains
Article
Published on
Journal: Frontiers in Cellular and Infection Microbiology
[Category] SARS, 유전자 메커니즘, 치료기술,
Journal: Frontiers in Cellular and Infection Microbiology
[Category] SARS, 유전자 메커니즘, 치료기술,
[키워드] 24 hour
acute respiratory syndrome
affected
analyzed
bioinformatics
caused
Cell
cellular
coronavirus
COVID-19
D614G mutation
Data mining
death
DEGs
different time point
differentially expressed gene
dysregulated
Effect
epithelial
experiment
Gene ontology
Genome
global pandemic
GO terms
Host
host cells
host response
Host transcriptional response
host-virus
hpi
identify
immune
IMPROVE
include
Infection
infections
inhibited
Intracellular
mechanism
Mutation
New York
NHBE
pathway
Pathways
Patient
positive
Post-infection
reported
response
resulting
RNA sequencing data
SARS-CoV-2
SARS-CoV-2 isolate
severe disease
shown
Signaling
signaling pathways
similarity
stability
strain
Strains
These data
transcript
translation
viral isolate
viral spike protein
Virology.
virus
virus replication
Washington
while
Wuhan, China
[DOI] 10.3389/fcimb.2022.1009328 PMC 바로가기
[DOI] 10.3389/fcimb.2022.1009328 PMC 바로가기
SARS-CoV-2 induced hepatic injuries and liver complications
Article
[키워드] abnormality
acute respiratory syndrome
ADE
Affect
Antibody-dependent enhancement
Case fatality rate
caused
clinician
Comorbidity
Complication
Coronavirus disease 2019
Coronavirus-2
COVID-19
COVID-19 pandemic
COVID-19 patient
demonstrated
detectable
diabetes
disease
Effect
Fecal sample
gastrointestinal tract
globe
HCC
hepatic dysfunction
hepatic injury
hepatocellular
Hepatocellular carcinoma
hepatocyte
highly pathogenic
hypertension
hypoxia
identification
Immunopathogenesis
in vitro
in vivo
Infection
investigated
involved
Ischemia
liver
Liver damage
Liver injury
mechanism
mechanism of liver damage.
molecular mechanism
multifactorial
Patient
Psychological
reported
Research
Respiratory samples
rising
RNA
RT-PCR
SARS-CoV-2
signaling pathways
significantly
Stress
systemic inflammation
Toxicity
[DOI] 10.3389/fcimb.2022.726263 PMC 바로가기
[DOI] 10.3389/fcimb.2022.726263 PMC 바로가기
Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methods
Article
[키워드] A549 cell
activated
Activation
acute respiratory syndrome
addition
Analysis
Atypical
candidate
caused
characterized
CLC
complications
CoV
COVID
COVID-19
COVID-19 infection
cytokine
deaths
DEGs
Determining
differentially expressed gene
disease
drug
effective
experimental validation
Gene Expression Omnibus
gene signatures
Genomics
GEO
GSE147507
human-to-human transmission
identify
IFNβ
IL-17
IL-1β
Illumina
in silico
In silico method
influenza A
Interaction
interferon beta
interferon regulatory factor
IRF3
IRF9
JQ1
knowledge
mechanism
Methylprednisolone
mock-treated
pathology
pathway
Pneumonia
Prednisolone
Quality control
receptors
RNA
RNA sequencing
RNA sequencing data
SARS CoV-2
signaling pathway
signaling pathways
small molecule
STAT2
the Coronaviridae
the disease
therapy
Transcription
Treatment
underlying disease
upstream
Viral protein
virus infection
was used
with COVID-19
Wuhan, China
[DOI] 10.1097/MD.0000000000029554 PMC 바로가기
[DOI] 10.1097/MD.0000000000029554 PMC 바로가기
Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease
용도 변경 항암 표피 성장 인자 수용체 억제제: 알츠하이머 병에서 신경 보호 효과의 메커니즘
Review
[키워드] Alzheimer's disease
Alzheimer’s disease
animal model
autophagy
breath
caused
disease
Disease progression
downstream signaling pathway
downstream signaling pathways
drug
drug re-positioning
Effect
effective
enhancement
epidermal
epidermal growth factor
epidermal growth factor receptor
Evidence
examined
explained
growth factor
human epidermal growth factor receptor-2
kinase inhibitors
mechanism
modulation
molecular mechanism
neurodegeneration
neurodegenerative
Neurodegenerative diseases
Neuroinflammation
neurological manifestation
neurological manifestations
Numerous
oxidative
oxidative stress
Perspective
positioning
Prospective clinical trial
recent
receptor
receptor inhibitor
Research
shown
signaling pathways
therapeutic approach
tyrosine
tyrosine kinase inhibitors
Tyrosine kinase inhibitors.
[DOI] 10.4103/1673-5374.332132 PMC 바로가기 [Article Type] Review
[DOI] 10.4103/1673-5374.332132 PMC 바로가기 [Article Type] Review
Transcriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reveals Crucial Genes Regulating Protein Ubiquitination
Article
[키워드] analysis
Analysis
ASB16
biological process
Cell
Characteristics
Cluster
conducted
core gene
COVID-19
COVID-19 pandemic
DEGs
detect
differentially expressed gene
enrichment
evaluate
expressed
facilitate
FBXO11
FOXA1
FOXC1
functional
GATA2
gene expression analysis
Genes
healthy controls
hsa-miR-1-3p
identify
Interaction
ITCH
macrophages
miRNA
molecular
mononuclear cell
Patient
performed
peripheral
Peripheral blood
platform
progression
protein ubiquitination
protein-protein interaction
regulate
Regulating
Regulatory
response
RNA sequencing
RNF130
severe COVID-19
signaling pathways
single-cell
transcription factors
Transcriptome
TRIM21
UBE2J1
was used
were expressed
YY1
[DOI] 10.12659/MSM.937532 PMC 바로가기
[DOI] 10.12659/MSM.937532 PMC 바로가기
Roles of mitochondrial DNA in dynamics of the immune response to COVID-19
Review article
[키워드] Absent in melanoma 2
ACE2angiotensin-converting enzyme 2
addition
Affect
AIM2Absent in melanoma 2
angiotensin-converting enzyme 2
ccf-mtDNAcirculating cell-free mitochondrial DNA
CFcystic fibrosis
cGASCyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase
chronic obstructive pulmonary disease
circulating
circulating cell-free mitochondrial DNA
COPDchronic obstructive pulmonary disease
Coronavirus disease 2019
COVID-19
COVID-19coronavirus disease 2019
Critical
Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase
cystic fibrosis
damage-associated molecular pattern
DAMPdamage-associated molecular pattern
Diseases
DNA
Endoplasmic reticulum
ERendoplasmic reticulum
gasdermin D
GSDMDgasdermin D
HIVhuman immunodeficiency virus
host cells
HPVhuman papillomavirus
Human immunodeficiency virus
human papillomavirus
ICUIntensive Care Unit
Idiopathic pulmonary fibrosis
immune function
immune response
Infection
inflammasome activation
Inflammatory response
intensive care unit
interferon stimulatory gene
IPFidiopathic pulmonary fibrosis
ISGinterferon stimulatory gene
leucine rich repeat
lncRNAlong non-coding RNA
long non-coding RNA
LRRleucine rich repeat
MAVSmitochondrial antiviral signaling
mesenchymal stem cell
Mitochondria
mitochondrial
mitochondrial antiviral signaling
mitochondrial DNA
mitochondrial reactive oxygen species
mitochondrial- damage-associated molecular pattern
MSCMesenchymal stem cell
Mt-DAMPmitochondrial- damage-associated molecular pattern
MtDNAmitochondrial DNA
mtROSmitochondrial reactive oxygen species
MyD88myeloid differentiation factor 88
myeloid differentiation factor 88
NBDnucleotide binding domain
NLRnucleotide binding domain and leucine rich repeat
nucleotide binding domain
nucleotide binding domain and leucine rich repeat
Open reading frame
ORFopen reading frame
pathogen-recognition receptors
Pathogens
pathway
Prognosis
provide
PRRpathogen-recognition receptors
reactive oxidative stress
Regulation
role
ROSreactive oxidative stress
SARS-CoV-2
SARS-CoV-2severe acute respiratory coronavirus 2
severe acute respiratory coronavirus 2
severity
signaling pathways
stimulator of interferon genes
STINGstimulator of interferon genes
targeting
therapeutic strategy
TLRToll-like receptor
TMPRSS2transmembrane serine protease 2
Toll-like receptor
transmembrane serine protease 2
[DOI] 10.1016/j.gene.2022.146681 [Article Type] Review article
[DOI] 10.1016/j.gene.2022.146681 [Article Type] Review article
Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2
네트워크 약리학 및 분자 도킹은 SARS-Cov-2로 인한 폐렴 치료에서 허브 호우 트 튜 니아 코타 타의 근본적인 약리학 적 메커니즘을 설명합니다.
Article
[키워드] 3CLpro
ACE2
activity
afzelin
analysis
antiviral properties
apigenin
applied
approach
Asian
caused
China
Combination
docking
DPP4
ELANE
expression profiling
Factor
Herb
herbal medicine
High-throughput sequencing
Houttuynia cordata
HSP90AA1
IL6
ingredient
integration
involved
Jak-STAT
Japan
kaempferol
MAPK
MAPK1
mechanism
metabolite
molecular
molecular docking
molecular dynamics
Molecular dynamics simulation
network
network pharmacology
NF-kB
pharmacological
pharmacological mechanism
Pharmacology
PI3K
Pneumonia
pneumonia.
provide
pulmonary infections
quercetin
reported
required
Research
SARS-CoV-2
Sequencing
SERPINE1
signaling pathways
STAT
suggested
systemic level
target
therapeutic
therapeutic effect
therapeutic potential
therapy
treat
treating
[DOI] 10.3390/v14071588 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/v14071588 PMC 바로가기 [Article Type] Article