Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond바이러스 감염 및 전신 염증: COVID-19 및 그 이후에서 배운 교훈Review Published on 2022-07-142022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response addition Antiviral Avian Influenza COVID-19 disease Effectiveness etiological agent facilitate high mortality highlight highly pathogenic highly pathogenic avian influenza human infection human infections immune immune responses immunomodulatory include Infection Inflammatory responses Influenza Influenza virus influenza viruses interferon lesson Local mechanism organ organ-specific pandemic Perturbation Replication respiratory respiratory infections responses responsible SARS-CoV-2 severe disease similarity systemic systemic inflammation target organ therapeutic strategy viral infection viral replication viral spread virus zoonotic [DOI] 10.3390/cells11142198 PMC 바로가기 [Article Type] Review
Mechanisms of Lung Injury Induced by SARS-CoV-2 InfectionSARS-CoV-2 감염으로 인한 폐 손상 기전Review Published on 2022-03-012022-09-11 Journal: Physiology (Bethesda, Md.) [Category] SARS, 치료제, [키워드] Anti-inflammatory antiviral therapeutics cause chemokine COVID-19 direct viral infection endothelial injury help identify immune immunomodulatory induced lung lung epithelial Lung injury lung organoid mechanism mitigate organ provide SARS-CoV-2 SARS-COV-2 infection target target organ therapeutic approaches Therapeutics viral infection [DOI] 10.1152/physiol.00033.2021 PMC 바로가기 [Article Type] Review
Early kidney injury predicts disease progression in patients with COVID-19: a cohort study조기 신장 손상은 CovID-19 환자의 질병 진행을 예측합니다 : 코호트 연구Research Article Published on 2021-09-272022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 치료기술, 치료제, [키워드] 95% CI Abstract adjusted Admission Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association baseline Blood urea nitrogen caused clearance clinical information clinician cohort study confounders coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient creatinine creatinine clearance decrease Disease progression early stage EGFR elevated estimated glomerular filtration rate filtration rate Generalized generalized linear mixed model glomerular filtration rate help Hematuria Huoshenshan Hospital identify independent risk factor independent risk factors Injury kidney Kidney function Kidney injury linear mixed model lung tissue medical record nitrogen on admission organ Patient patients patients with COVID-19 poor prognosis predict proportion Proteinuria receptor respiratory respiratory syndrome coronavirus respiratory syndrome coronavirus 2 Result retrospective cohort study SARS-CoV-2 serum creatinine severe respiratory syndrome Severe respiratory syndrome coronavirus 2 significantly supplementary material target organ trajectory urea uric acid Wuhan Wuhan, China [DOI] 10.1186/s12879-021-06576-9 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial CellsSARS-CoV-2 분리주는 인간 면역 세포에서 손상된 복제를 보여주지만 폐 상피 세포에서 복제하고 타고난 면역을 유도하는 차등 능력을 보여줍니다Research Article Published on 2021-08-112022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Calu Calu-3 cell calu-3 cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines dendritic cells epithelial epithelial cells Finnish Gene Expression HCoV Human human cell human cells human DC human lung human macrophage IFN IFNs Immune cell immune cells Impaired induce infect Infection Inflammatory response Inflammatory responses information Innate Innate immunity interferon interferon (IFN) response interferon response interferons interferons (IFNs interferons (IFNs) isolate isolates knowledge lung epithelial cell Lung epithelial cells Lymphocytes macrophages mechanism Monocytes open organ pandemic Pathogenesis pathogenesis of SARS-CoV-2 regulate Regulation replicate replicated Replication respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus show Spread target organ TPCK-treated trypsin type I Type III IFN Vero E6 cell viral replication [DOI] 10.1128/Spectrum.00774-21 PMC 바로가기 [Article Type] Research Article
The most important biomarker associated with coagulation and inflammation among COVID-19 patientsCOVID-19 환자에서 응고 및 염증과 관련된 가장 중요한 바이오마커Review Published on 2021-07-012022-09-11 Journal: Molecular and cellular biochemistry [Category] 바이오마커, 치료제, [키워드] Abnormalities abnormality acute lung injury Biomarker caused Coagulation coagulation test Coagulopathy Complication conditions coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient COVID-19 patients Critical CRP D-dimer Disseminated intravascular coagulopathy early stage early stages elevated ferritin fibrinogen fibrinogen degradation products fibrinogen level Fibrinogen levels IL-6 Immunity Infection Inflammation inflammatory biomarkers inflammatory change inflammatory changes initial lack LDH leads Lung injury Lungs management multiorgan failure occur organ partial thromboplastin time Patient patients patients worldwide Platelet Platelet count Prophylaxis prothrombin Prothrombin time Respiratory failure severe patients significantly suggested supportive care target organ Test screening the disease thromboembolic THROMBOPLASTIN Viral virus [DOI] 10.1007/s11010-021-04122-4 PMC 바로가기 [Article Type] Review
AntagomiRs: A novel therapeutic strategy for challenging COVID-19 cytokine stormAntagomiRs: COVID-19 사이토카인 폭풍에 도전하기 위한 새로운 치료 전략Article Published on 2021-04-012022-09-11 Journal: Cytokine & growth factor reviews [Category] MERS, SARS, 진단, 치료제, [키워드] Activation actual antagomiRs ARDS cardiovascular disease characterized clinical manifestations coronavirus COVID-19 COVID-19 cytokine storm COVID-19 pandemic cytokine Cytokine storm Cytokines death demonstrated develop IL-6 lung failure Lungs MicroRNAs organ other coronavirus other coronaviruses reduce reducing Safe secure severe patients specificity target organ the cytokine storm the disease the patient therapeutic strategy therapy Treatment Vaccine widespread [DOI] 10.1016/j.cytogfr.2020.09.001 PMC 바로가기 [Article Type] Article
Can bilirubin nanomedicine become a hope for the management of COVID-19?빌리루빈 나노의약품이 코로나19 관리의 희망이 될 수 있을까?Article Published on 2021-04-012022-09-11 Journal: Medical Hypotheses [Category] 치료제, [키워드] administration Anti-inflammatory antioxidant antiviral activities Bilirubin Biliverdin Can cardiovascular diseases clinical study complications COVID-19 diabetes disorders dysfunction Efficacy intravenous Intravenous administration management metabolic syndrome nanomedicine Nanomedicine. Nanotechnology obesity offer organ pharmacological efficacy reduced risk syndrome target organ therapeutic Toxicity unique with COVID-19 [DOI] 10.1016/j.mehy.2021.110534 PMC 바로가기 [Article Type] Article
Targeting MMP-Regulation of Inflammation to Increase Metabolic Tolerance to COVID-19 Pathologies: A HypothesisCOVID-19 병리에 대한 대사 내성을 증가시키기 위한 염증의 MMP 조절 목표: 가설Essay Published on 2021-03-062022-09-01 Journal: Biomolecules [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 AMPK Combination Coronavirus-2 COVID-19 damage develop elicit elicited energy metabolism Evidence focus Host human host hyper-inflammation immunopathology increase individual Infection Inflammation Interaction lung matrix metalloproteinase matrix metalloproteinases mechanism metabolic metabolic tolerance metabolism mild symptoms MMP Mounting multiorgan failure organ organs pathogen Pathogens Pathologies pathology Perturbation Pneumonia regulated respiratory respiratory distress Respiratory failure SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Spectrum syndrome systemic inflammation target target organ target organs targeting Therapeutic approach therapeutic approaches therapeutic target therapeutic targets tissue damage Viral while [DOI] 10.3390/biom11030390 PMC 바로가기 [Article Type] Essay