A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learningResearch Published on 2024-05-172024-09-05 Journal: Clinical Proteomics [Category] update2024, [키워드] COVID-19 machine learning organ system Sepsis targeted proteomics [DOI] 10.1186/s12014-024-09488-3 PMC 바로가기 [Article Type] Research
The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsisResearch Article Published on 2024-04-172024-09-05 Journal: Molecular Medicine [Category] update2024, [키워드] Biomarker discovery machine learning MIS-C Sepsis targeted proteomics [DOI] 10.1186/s10020-024-00806-x PMC 바로가기 [Article Type] Research Article
A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumorsarticle Published on 2023-09-292024-09-05 Journal: Clinical Proteomics [Category] update2024, [키워드] Glioblastoma/Glioma High grade tumors Low grade tumors Meningioma Selected/Multiple reaction monitoring (SRM/MRM) targeted proteomics [DOI] 10.1186/s12014-023-09426-9 PMC 바로가기 [Article Type] article
Germ Cell–Specific Proteins AKAP4 and ASPX Facilitate Identification of Rare Spermatozoa in Non-Obstructive AzoospermiaResearch Published on 2023-04-212024-09-05 Journal: Molecular & Cellular Proteomics : MCP [Category] update2024, [키워드] ACRV1 AKAP4 AKAP4_HUMAN ASPX_HUMAN Biomarkers Imaging flow cytometry male infertility non-obstructive azoospermia targeted proteomics testis-specific proteins [DOI] 10.1016/j.mcpro.2023.100556 PMC 바로가기 [Article Type] Research
Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learningarticle Published on 2023-02-212024-09-05 Journal: Molecular Medicine [Category] update2024, [키워드] Biomarker cell types COVID-19 long-COVID machine learning organ system targeted proteomics [DOI] 10.1186/s10020-023-00610-z PMC 바로가기 [Article Type] article
A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort studyResearch article Published on 2022-06-092022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, 임상, [키워드] accelerate Accuracy agency APACHE II assessment Berlin Biomarker Biomarkers Charité clinical clinical disease progression Clinical outcome clinical risk clinical trials Cohort conducted Council COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 severity death Dexamethasone disease prognosis disease severity education ERC European finding foundation funding Germany hallmark Healthcare system healthy individuals help hospitalised introduced LC-MS/MS LLOQ machine learning median Medicine Mild Mobility moderate multiplex node observational study outcome Patient patient cohort patients with COVID-19 peptide peptides predicted Prognosis Prognostic value Protein proteomics quantification Registered registry Research resource SARS-CoV2 Science sensitivity severe COVID-19 severity Severity stratification SOFA Spectrometry Standard of care stratified Support supported survival System targeted proteomics the median the WHO Therapies Treatment Wellcome Trust [DOI] 10.1016/j.eclinm.2022.101495 [Article Type] Research article
Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutantsReview Published on 2021-08-122022-11-01 Journal: Clinical Proteomics [Category] COVID-19, [키워드] acute respiratory syndrome anti-viral antibody assays Betacoronavirus clinical study Combination continuous monitoring coronavirus coronavirus disease COVID-19 cross-reactivity diagnostic Diseases Emerging mutations evaluate facilitate functional identify Immunity immunoassays immunoprecipitation information knowledge mass mass spectrometry molecular diagnostics mutant mutations pandemic Pandemics Perspective Population post-translational modifications Protein protein–protein interactions proteomic proteomics quantification rapid response Research RNA sequencing RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus sensitivity Serology diagnostics serology test specificity targeted proteomics translational Viral protein Viral RNA viruses while [DOI] 10.1186/s12014-021-09325-x PMC 바로가기 [Article Type] Review
Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approachesSARS-CoV-2 유도 병인 및 잠재적 진단 접근법에 대한 더 나은 이해를 위한 질량 분석 기반 단백질체 플랫폼Review Published on 2021-05-012022-09-11 Journal: Proteomics [Category] SARS, 유전자 메커니즘, 진단, [키워드] AMPK applied approach Biomarkers cellular Comparative analysis comparative proteomics COVID-19 dataset diagnostic EGFR EPHA2 Ephrin functional humans in vitro experiments indicate Infection kinase kinase-substrate signaling kinases knowledge MAPK mass mass spectrometry mechanism molecular mechanism molecular mechanisms Pathogenesis pathway Pathways phosphoproteome PI3K platform post-translational modifications prognostic Protein protein targets protein-protein interaction proteome proteomic proteomics receptor SARS-CoV-2 SARS-COV-2 infection signaling pathways targeted proteomics the SARS-CoV-2 Therapeutic strategies tissue tissue sample tissue samples top-down proteomics. Viral viral infection while [DOI] 10.1002/pmic.202000279 PMC 바로가기 [Article Type] Review
Proteomics: A Tool to Study Platelet FunctionReview Published on 2021-04-302023-06-12 Journal: International Journal of Molecular Sciences [Category] MERS, [키워드] LC-MS/MS mass spectrometry Phosphoproteomics platelet transfusion proteomics Platelets precision medicine PTMs Signaling targeted proteomics [DOI] 10.3390/ijms22094776 PMC 바로가기 [Article Type] Review
Perspective on Proteomics for Virus Detection in Clinical SamplesArticle Published on 2020-11-062023-07-06 Journal: Journal of Proteome Research [Category] SARS, [키워드] COVID-19 mass spectrometry parallel reaction monitoring peptide selection PRM SARS-CoV-2 targeted mass spectrometry targeted proteomics virus diagnostics virus proteomics. [DOI] 10.1021/acs.jproteome.0c00674 PMC 바로가기