CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newbornsArticle Published on 2022-08-022022-10-06 Journal: Nature Communications [Category] 진단, [키워드] Antigen cationic CD8 characterized children dendritic cell event identify immune system Immunity immunization in vivo model induce Infection kinase mechanism of action mice morbidity and mortality murine Neonatal Newborn Pathogens pediatric Phosphoproteomics pre-fusion PROTECT Quantitative receptor respiratory respiratory syncytial virus respiratory viral resulting RSV Signaling single dose synergistic T-cell Th1 cells Th1 cytokine Vaccine virus [DOI] 10.1038/s41467-022-31709-2 PMC 바로가기 [Article Type] Article
Redefining COVID-19 Severity and Prognosis: The Role of Clinical and ImmunobiotypesImmunology Published on 2021-09-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] 3-Hydroxyisovaleric acid 95% CI 95% confidence interval Abnormalities Accuracy adaptive adverse outcome albumin AUC BMI body mass index calculated CD8+ circulating clinical COVID-19 COVID-19 severity Cox proportional-hazards model Critical disease death Diagnosis Disease progression driver effector memory explain feature hazard hemoglobin hypoxia Immunity immunological IP-10 lack lactate dehydrogenase LDGs low-density malic acid MCP-1 metabolomic metabolomics monocyte chemoattractant protein-1 MOST myoinositol NETs Neutrophil extracellular traps Odds ratio ordinal logistic regression Patient plasma Predictive Prognosis prognostic model Result role Serum level severity and prognosis T cells Th1 cells traits TRIM63 troponin variable was tested with COVID-19 [DOI] 10.3389/fimmu.2021.689966 PMC 바로가기 [Article Type] Immunology
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged miceClinical and Translational Article Published on 2021-03-122022-11-01 Journal: Med (New York, N.Y.) [Category] COVID-19, MERS, SARS, [키워드] Abstract Adaptive immune response administration Adults affected aging antibodies Antibody Response approach booster dose caused CD4 CD8 CD8+ T cells Cell cellular ChAdOx1 ChAdOx1 nCoV-19 changes in Clinical outcome Context COVID-19 COVID-19 vaccine COVID-19 vaccines effective effectors elicit ENhance finding follicular funding generate Germinal center Health Humoral immunity IgG and IgM immune response immune system immunogenicity induce Infection influence intramuscular limit magnitude Measures Medicine mice morbidity and mortality Older outcome performed plasma pre-clinical testing protective immunity reduced Regulatory required risk factor robust SARS-CoV-2 SARS-COV-2 infection second dose single dose single vaccination Spread stimulate supported T follicular helper cells Th1 cells vaccination Vaccine vaccine candidate virus-neutralizing antibodies worldwide pandemic [DOI] 10.1016/j.medj.2020.12.006 PMC 바로가기 [Article Type] Clinical and Translational Article
SARS-CoV-2 mRNA Vaccines: Immunological Mechanism and BeyondReview Published on 2021-02-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome adaptive Adaptive immune response adaptive immune responses Adaptive immunity animal model antibodies B cell B cell response cells clinical study contribute coronavirus coronavirus disease COVID-19 develop effective Efficacy elicit germinal centers Human Immunity Infection long-lived plasma cells memory B cells Messenger RNA modulate mRNA mRNA vaccines pathogen post vaccination PROTECT Respiratory disease SARS-CoV-2 T cell T cell responses T follicular helper cells Th1 cells Vaccine while [DOI] 10.3390/vaccines9020147 PMC 바로가기 [Article Type] Review
The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2ACE2에 의해 지원되는 COVID-19 감염에서 JAK-STAT 신호 전달 경로의 잠재적 관련성Article Published on 2021-02-052022-09-11 Journal: Gene [Category] 유전자 메커니즘, [키워드] ACE2 Activation angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 B cells CD8 Cell coronavirus coronavirus disease correlation CoV infection COVID-19 COVID-19 infection downstream effective enzyme epithelial cells expected FOXP3 Gene Expression GSEA HAEs helper T cell helper T cells human airway epithelial human airway epithelial cells Immune cell immune response immunological indicated Infection investigated JAK-STAT signaling JAK-STAT signaling pathway macrophages mechanism nucleotide overactivation overexpressed pathway public health receptor regulate Regulatory reported respiratory SARS-CoV infection SARS-COV-2 infection Severe acute respiratory syndrome Signal-gene GSEA. similarity STAT T cell T cells Th1 cells Therapeutic strategies Treg [DOI] 10.1016/j.gene.2020.145325 PMC 바로가기 [Article Type] Article
The regulation of CD4+ T cells during malariaarticle Published on 2020-01-312024-09-01 Journal: Immunological Reviews [Category] 말라리아, [키워드] CD4+ T cells immunoregulation Inflammation malaria Tfh cells Th1 cells [Article Type] article
Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune EncephalomyelitisOriginal Research Published on 2020-01-142023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] blood-brain barrier dendritic cells experimental autoimmune encephalomyelitis ICAM-1 ICAM-2 T cell activation Th1 cells Th17 cells [DOI] 10.3389/fimmu.2019.03056 PMC 바로가기 [Article Type] Original Research
OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infectionArticle Published on 2019-06-012023-06-19 Journal: Journal of hepatology [Category] B형 간염, [키워드] antiviral immunity Cytokines Follicular T helper cells Immunotherapy Th1 cells Viral hepatitis [DOI] 10.1016/j.jhep.2019.02.016
[Correlation between CTL and Th1 cell proportion in peripheral blood of liver transplantation recipients and the success of hepatitis B vaccination]Randomized Controlled Trial Published on 2019-02-262023-06-18 Journal: Zhonghua yi xue za zhi [Category] B형 간염, [키워드] CD8 positive T lymphocytes liver transplant Th1 cells Vaccine [DOI] 10.3760/cma.j.issn.0376-2491.2019.08.009 [Article Type] Randomized Controlled Trial
Analysis of the lymphocyte cell population during malaria caused by Plasmodium vivax and its correlation with parasitaemia and thrombocytopaenia말라리아를 유발하는 Plasmodium vivax에 의한 림프구 세포 집단 분석 및 기생충 혈증과 혈소판 감소증과의 상관관계Research Published on 2018-08-202024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] Parasitaemia Plasmodium vivax Platelets Th1 cells Th2 cells [DOI] 10.1186/s12936-018-2443-x PMC 바로가기 [Article Type] Research