Biochemistry – Page 11 – Communicable Diseases Research

Severe acute kidney injury in COVID-19 patients is associated with in-hospital mortality

COVID-19 환자의 심각한 급성 신장 손상은 병원 내 사망률과 관련이 있습니다.

Research Article

Published on 2020-12-092022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection

TMPRSS2와 카텝신 B/L을 함께 표적으로 삼는 것은 SARS-CoV-2 감염에 대해 상승적일 수 있습니다

Research Article

Published on 2020-12-082022-08-13
Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, SARS,

[키워드] ‘repurposing’ drugs achievement activate Activation blockade blocking blocking virus entry cathepsin Cathepsin B/L Cell cell lines cell population levels cell types cells clinical trials combination therapies combination therapy corresponding protease expression level COVID-19 COVID-19 pandemic cysteine cysteine protease cysteine proteases deployability dose-dependent manner drug drug combination drug combinations drugs targeting Effect Efficacy Efficiency effort entry of SARS-CoV-2 Evidence expression level facilitate help highlighting host protease host proteases host serine protease IMPROVE in vitro in vitro data in vivo independent independent entry pathway inhibitor inhibitors involved mathematical mathematical model minimal toxicities pathway Pathways potential treatment option predict predicted Prevent protease Proteases required SARS-CoV entry SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine Single Cell Spike protein synergistic Synergistic drug combination Synergistic drug combinations synergy target cell target cells targeting the cell tissue tropism TMPRSS2 toxicities Treatment triggered virus entry
[DOI] 10.1371/journal.pcbi.1008461 PMC 바로가기 [Article Type] Research Article

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

SARS-CoV-2 및 ORF8이 결여된 382-nt 결실 분리주에 의한 인간 비강 상피 세포의 감염은 유사한 바이러스 동역학 및 숙주 전사 프로필을 나타냅니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 치료기술,

[키워드] absence airway airway epithelial cells anti-viral gene up-regulation anti-viral signaling pathway anti-viral signaling pathways apical side basolateral secretion causative agent cell type cell types comparable conserved expression coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 patients CXCL10 CXCL10 production cytokine cytokine production Cytokines differentiated NEC differentiated NECs distinct gene subset distinct gene subsets Duration of infection early response elevated elicited epithelial epithelial cell epithelial cells examined genomes global healthcare greater magnitude H3N2 healthy nasal-tissue highlight Host host gene expression Host immune response Host transcriptional response host-response hours post-infection hpi IL-6 Immune cell infiltration immune cells immune response impair in vitro In-vitro infancy infected cells infected NEC infected NECs Infection Infection of NEC Infection of NECs Infection with Δ382 infiltrating immune cell infiltrating immune cells Inflammatory response Influenza influenza strain late time-point late time-points less modulating Nasal Epithelial cells NECs Novel coronavirus novel coronavirus SARS-CoV-2 ORF8 other SARS-CoV-2 genes Pathogenesis patient sera patients plasticity post-infection time-point pro-inflammatory cytokine pro-inflammatory cytokines released reported reveal SARS-CoV-2 SARS-CoV-2 and Δ382 infection SARS-CoV-2 genes SARS-COV-2 infection Screening severe disease significantly similar replication kinetics similarities similarity Singapore stem cell stem cells subsequent cytokine production temporal up-regulation therapeutic node TNFα transcriptional transcriptional profile Transcriptome transcriptome analysis transcripts transcripts mapping understanding Viral viral clearance viral kinetics virus particle virus particles wild-type and Δ382 wild-type SARS-CoV-2 Δ382 Δ382 infected cell Δ382 infected cells Δ382 infection
[DOI] 10.1371/journal.ppat.1009130 PMC 바로가기 [Article Type] Research Article

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

SARS-CoV-2와 SARS-CoV 사이의 자연 돌연변이는 교차 반응성 항체에 의한 중화를 결정합니다

Research Article

Published on 2020-12-042022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 변종, 진단,

[키워드] Amino acid antibody antibody cross-reactivity antigenic variation Author binding binding affinity caused conformations conserved convalescent SARS patient CoV antibodies COVID-19 pandemic CoVs CR3022 CR3022 epitope cross-neutralizing epitope cross-react cross-reactive antibody cross-reactive vaccine cross-reactive vaccines cryo-EM determine Epidemic epitope Epitopes experiments Fab Genetic implication Interaction investigated Mutagenesis mutant N-terminal domain natural mutation neutralization neutralizing antibody not neutralize NTD P384A provide RBD Receptor binding domain SARS-CoV SARS-CoV antibodies SARS-CoV antibody SARS-CoV spike protein SARS-CoV-2 SARS-like coronavirus SARS-like coronaviruses SARS-like CoV SARS-like CoVs SARS-like viruses similarity single mutation Spike protein subunit target the RBD the spike protein therapeutic Therapeutics trimer Vaccine X-ray crystallography
[DOI] 10.1371/journal.ppat.1009089 PMC 바로가기 [Article Type] Research Article

Insights on cross-species transmission of SARS-CoV-2 from structural modeling

구조 모델링에서 SARS-CoV-2의 종간 전파에 대한 통찰력

Research Article

Published on 2020-12-032022-08-13
Journal: PLoS Computational Biology [Category] Biochemistry, Fulltext, MERS, SARS, 변종,

[키워드] Accuracy ACE2 ACE2 orthologs ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus affinity-enhancing mutation affinity-enhancing mutations Amino acid amino acid residue amino acids antiviral therapeutics atomic level benefit blueprint chicken complement computational modeling Computational study confirmed case confirmed cases Contact coronavirus country Cross-species transmission develop disrupt Drug development experiments explain geographical distribution global pandemic help highlight host cell host cell membrane host receptor Human humans in some infect Infection infection cycle infection process insight Interaction investigated key amino acid key amino acids key polar Like mice molecular feature non-conservative mutation non-conservative mutations not applicable other coronaviruses pandemic predict protein interactions provide question receptor protein respiratory responsible risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein several ACE2 amino acid residues several ACE2 ortholog several ACE2 orthologs severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 species Spike protein structural framework Structural properties structural property susceptible the SARS-CoV-2 therapeutic purposes Therapeutics thought three-dimensional structure Transmission transmitted Viral viral infection viral infections Viral protein viral spike protein viral-host protein interaction viral-host protein interactions viruses widespread wild animals
[DOI] 10.1371/journal.pcbi.1008449 PMC 바로가기 [Article Type] Research Article

Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19

COVID-19 부담이 낮은 국가의 의료 종사자 중 SARS-CoV-2에 대한 항체

Research Article

Published on 2020-12-032022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, 진단,

Biodistribution and serologic response in SARS-CoV-2 induced ARDS: A cohort study

SARS-CoV-2 유발 ARDS의 생체분포 및 혈청학적 반응: 코호트 연구

Research Article

Published on 2020-11-242022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 진단, 치료기술,

[키워드] 30-Day mortality accompanied acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antibody Antibody detection antibody formation Antiviral treatment ARDS binding domain biodistribution blood sample Blood samples Chain Reaction cohort study collected Concentration coronavirus COVID-19 detectable dialysate disease severity distribution enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay high viral load ICU treatment IgA antibodies IgA antibody IgM intensive care intensive care treatment investigated majority Most patient Most patients Neutralizing Neutralizing antibodies neutralizing antibody no difference non-survivor Non-survivors oropharyngeal swab oropharyngeal swabs Patient patients polymerase chain polymerase chain reaction positive Quantitative RBD remained respiratory respiratory distress Result retrospective reverse transcription reverse transcription quantitative polymerase chain reaction RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral load serologic Serologic response serologic testing severe acute respiratory syndrome Coronavirus severe ARDS severe corona virus disease significantly lower single-center study suffered survival survivor syndrome tested the patient tissue tracheal Tracheal aspirates Viral Viral load Virus Disease was performed
[DOI] 10.1371/journal.pone.0242917 PMC 바로가기 [Article Type] Research Article

Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure

COVID-19 관련 호흡 부전이 있는 기계 환기 환자의 결과

Research Article

Published on 2020-11-232022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

Testing IgG antibodies against the RBD of SARS-CoV-2 is sufficient and necessary for COVID-19 diagnosis

SARS-CoV-2의 RBD에 대한 IgG 항체 검사는 COVID-19 진단에 충분하고 필요합니다.

Research Article

Published on 2020-11-232022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 진단, 치료기술,

C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19

코로나19로 입원한 환자의 예후 지표로서의 C 반응성 단백질

Research Article

Published on 2020-11-202022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] Admission Analysis association conducted COVID CRP CRP level CRP levels CRP value CRP values declines died Disease progression elevated entire cohort facilitate Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient ICU ICU admission in-hospital mortality IQR linear median medical record medical records Patient patients patients with COVID-19 peaked prognostic indicator progression Protein recent reported retrospective cohort risk stratification Seven Severity of disease significantly higher Support System the median the patient those who survived threshold utility with COVID-19
[DOI] 10.1371/journal.pone.0242400 PMC 바로가기 [Article Type] Research Article