Biochemistry – Page 3 – Communicable Diseases Research

The landscape of antibody binding in SARS-CoV-2 infection

SARS-COV-2 감염에서 항체 결합의 풍경

Research Article

Published on 2021-06-182022-08-13
Journal: PLoS Biology
[Category] Biochemistry, MERS, SARS, 진단, 치료법,

Human IgG and IgA responses to COVID-19 mRNA vaccines

COVID-19 mRNA 백신에 대한 인간 IgG 및 IgA 반응

Research Article

Published on 2021-06-162022-08-13
Journal: PLoS ONE
[Category] Biochemistry, MERS, SARS, 진단,

SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1

SARS-COV-2 엔벨로프 (E) 단백질은 숙주 단단한 접합 단백질 ZO1의 PDZ- 도메인 -2와 상호 작용한다.

Research Article

Published on 2021-06-092022-08-13
Journal: PLoS ONE
[Category] Biochemistry, MERS, SARS, 변종, 진단,

[키워드] airway amplified approach approach approaches array binding Biotin C-terminal cell layer chloride complementary consolidation contribute contributing to COVID-19 patients disease severity domain dysfunction E protein ECT envelope epithelial epithelial cell epithelial cells epithelial tissues extreme Fluorescence fusion protein global pandemic homogenous Host HTRF humans interact Interaction Intervention lead Lungs membrane protein mitigate molecular morbidity motif multifunctional mutant Pathogenesis Pathologies peptide Protein reduce respiratory Respiratory disease respiratory tract SARS-CoV-1 SARS-CoV-2 screened secretion sequence severe pneumonia severe respiratory disease singular target the lungs a the SARS-CoV-2 tight junction tissues virus virus spread Zona
[DOI] 10.1371/journal.pone.0251955 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains

SARS-CoV-2: 잠재적으로 더 치명적인 균주의 가능한 재조합 및 출현

Research Article

Published on 2021-05-252022-08-13
Journal: PLoS ONE
[Category] Biochemistry, COVID-19, SARS,

Dexamethasone vs methylprednisolone high dose for Covid-19 pneumonia

코비드-19 폐렴에 대한 덱사메타손 대 메틸프레드니솔론 고용량

Randomized Controlled Trial

Published on 2021-05-252022-08-13
Journal: PLoS ONE
[Category] Biochemistry, MERS, SARS, 임상,

[키워드] acute respiratory syndrome Administered alveolar pressure Ambispective cohort study Analysis applied ARDS Berlin protocol C-reactive protein calculated can be used carried Chain Reaction Chest Chest tomography clinic Clinical outcome completion coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 pneumonia CRP D-dimer decrease Dexamethasone dexamethasone 6 mg DHL diagnosed discharge dose DXM effective therapy evaluated Follow-up followed by ground-glass imaging High dose high-complexity clinic high-dose methylprednisolone Hospitalization Hospitalized hospitalized patient hospitalized patients inclusion criteria Infectious disease Infectious diseases inspired oxygen fraction institutional protocol intensive care intensive care unit intravenous Invasive mechanical ventilation Laboratory laboratory result Laboratory results LDH less living-dead status marker material Medellín, Colombia Methylprednisolone Mortality MTP group Not applied optimal dose outpatient consultation oxygen P-value PaFi Patient patients treated Pneumonia polymerase chain polymerase chain reaction Prednisone proportion prospective cohort protocol Pulmonology radiological Randomized controlled studies readmission Recovery time required responsible Result Sample Sample size SARS-CoV2 Seven Severe acute respiratory syndrome severe ARDS Severe COVID-19 pneumonia severe SARS severity shown significantly statistically subsequent supplementary oxygen survival survival analysis telephone the patient tomography total population transfer treated Treatment
[DOI] 10.1371/journal.pone.0252057 PMC 바로가기 [Article Type] Randomized Controlled Trial

Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity

COVID-19 감염 또는 백신 접종과 관련된 혈전성 혈소판 감소증: 혈소판 인자 4 자가면역의 가능한 경로

Review

Published on 2021-05-242022-08-13
Journal: PLoS Medicine
[Category] Biochemistry, SARS, 진단,

[키워드] Adverse reaction Adverse reactions Autoimmunity COVID-19 Infection mechanism Platelet SARS-CoV-2 thrombotic Thrombotic thrombocytopenia Vaccinations with COVID-19
[DOI] 10.1371/journal.pmed.1003648 PMC 바로가기 [Article Type] Review

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

스파이크 당단백질의 DC/L-SIGN 인식은 SARS-CoV-2 트랜스 감염을 촉진하고 글리코미메틱 길항제에 의해 억제될 수 있습니다

Research Article

Published on 2021-05-202022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 바이오마커,

[키워드] ACE2 antigen-presenting cells authentic SARS-CoV-2 virus capture Cell cell lines cell surface CLR CLRs Concentration COVID-19 pathogenesis DC-SIGN defined described dissemination Effectiveness ENhance entry receptor envelope protein evaluated event examined Factor Final glycan glycosylation Host identify immune cells immunomodulation IMPROVE Infection inhibited innate immune response Interaction involved L-SIGN Langerin lung tissue mechanism molecular monocyte Monocytes mucosa opens pandemic Pathogens promote Protein pseudovirus receptor receptors recognize respiratory respiratory mucosa SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike protein SARS-CoV-2 virus SIGN spike spike glycoprotein Spike protein Spread T-lymphocytes target cell target cells tested the cell the SARS-CoV-2 These data trans transfer transmission rate unique Vero E6 VERO E6 cells Viral viral infection viral spike protein virus virus viruses while
[DOI] 10.1371/journal.ppat.1009576 PMC 바로가기 [Article Type] Research Article

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

신규 결합 에피토프를 갖는 SARS-CoV-2 중화 항체의 구조적 기초

Research Article

Published on 2021-05-072022-08-13
Journal: PLoS Biology
[Category] Biochemistry, SARS, 진단,

[키워드] ACE2 receptor acute respiratory syndrome coronavirus Ad5-hACE2 Ad5-hACE2 transduction mouse model angiotensin antibodies antibody antiviral efficiency applied binding binding epitope caused characterized coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 domain Economy epitope Epitopes global public health H2L2 platform H2L2 transgenic mice hACE2 help High-resolution X-ray crystallography structures human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human immunoglobulin human immunoglobulin variable regions humanized NAb identify immunize Immunoglobulin injection mAb mAb-related therapeutic intervention mAb-related therapeutic interventions monoclonal antibody mouse model NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody novel non-blocking epitope pandemic platform PR1077 PR953 PR961 Prophylactic provide provided RBD RBM receptor-binding motif recombinant vaccines regions respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein spike receptor-binding domain Structural analysis Structure subsequent tested the antibody the SARS-CoV-2 the spike protein therapeutic interventions therapy transgenic mice treatment groups variable regions X-ray crystallography
[DOI] 10.1371/journal.pbio.3001209 PMC 바로가기 [Article Type] Research Article

Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

SARS-CoV-2 스파이크 단백질을 표적으로 하는 생물의학적 개입으로 인한 급격한 진화 탈출의 위험

Research Article

Published on 2021-04-282022-08-13
Journal: PLoS ONE
[Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 affinity Analysis antibody antibody-based prophylactics comparable COVID-19 Critical Decay kinetics deleterious mutation develop domain epitope Epitopes escape mutant escape mutants expected focus Frequency Genetic variation Immune escape immune evasion Immunity immunization in vitro infect cell Intervention molecular molecular target Mutation NAb NAbs natural antigens natural immunity Neutral Neutralizing antibodies neutralizing antibody new strain overlap passive immunization Positive selection potential mechanism predict question raise raised raising RBD RBD-targeting nAbs SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 spike protein sequence Spike protein Strategy structure-function surveillance data the RBD therapeutic timeline Transmissibility vaccinal Vaccine Vaccines Viral Viral immune evasion virus virus escape neutralizing antibodies widespread wild type
[DOI] 10.1371/journal.pone.0250780 PMC 바로가기 [Article Type] Research Article

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

SARS-CoV-2 및 기타 인간 코로나바이러스 스파이크 단백질은 인간 기도의 온도 및 프로테아제에 맞게 미세 조정됩니다.

Research Article

Published on 2021-04-222022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘,

[키워드] activate activated Activation of SARS-2-S adaptive mechanism adaptive mechanisms adjusted airway adaptation airways alternative route authentic virus replication Author cathepsin L cathepsin L pathway cathepsin-rich cells caused cell tropism common cold common cold coronavirus contrary contributed coronavirus coronavirus spike protein coronavirus virulence coronaviruses SARS-CoV COVID-19 pandemic Critical D614 variant D614G mutation deletion mutants effective ENhance explain extended loop length feature furin furin recognition motif G614 variant HCoV HCoV-229E high transmissibility of SARS-CoV-2 highly pathogenic human airway human airways human coronaviruses human host human respiratory tract increase indicate intrinsic temperature preference loop deletion mutant loop deletion mutants lower airways mechanism MERS MERS-CoV mild common cold other coronavirus other coronaviruses pathogenic HCoV-229E virus pathology predominant processing produced promote property protease protease condition protease conditions Proteases Protein pseudoviruses pseudoviruses of SARS-CoV-2 replaced Replication respiratory respiratory tract S protein S protein stability S proteins S1/S2 cleavage loop SARS-2-S SARS-2-S-driven entry SARS-CoV SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 spike SARS-CoV-2 stability severe pneumonia significantly increased spike activator spike property Spike protein Spike proteins spike stability spike-D614 spike-G614 variant Spread surface protease surface proteases temperature temperature and protease conditions the S protein the SARS-CoV-2 the spike protein TMPRSS13 TMPRSS13 protease TMPRSS2 transmissibility of SARS-CoV-2 upper airways upper or lower airways Usage Viral viral spike protein virulent coronavirus virulent coronaviruses virus virus entry virus preference virus spread virus transmission Zoonotic introduction
[DOI] 10.1371/journal.ppat.1009500 PMC 바로가기 [Article Type] Research Article