An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variantsSARS-CoV-2에 대한 조작된 미끼 수용체는 단백질 S 서열 변이체에 광범위하게 결합합니다Research Article Published on 2021-02-172022-08-13 Journal: Science Advances [Category] Biochemistry, 변종, [키워드] ACE2 active against bats bind binding competing ectodomain escape favor followed by high affinity host cell host cell membrane Human Hypothesis in vitro Infection Mutagenesis mutant neutralize outbreak promise protein S receptor Receptor-binding domain receptors recognize sACE2 SARS-associated betacoronaviruses SARS-associated virus SARS-associated viruses SARS-CoV-2 SARS-related coronavirus saturation sequence similarity the receptor-binding domain variant Viral viral escape virus variant virus variants viruses wild-type [DOI] 10.1126/sciadv.abf1738 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and developmentSARS-CoV-2 지향성, 진입, 복제 및 전파: 약물 발견 및 개발에 대한 고려 사항Review Published on 2021-02-172022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, MERS, [키워드] acute respiratory syndrome coronavirus antiviral activity appear cellular infection systems cellular interaction Compound coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 disease drug Drug discovery Effect effort food framework Hospitalization identify immortalized cell line in vitro initial involved knowledge Mild symptom mild symptoms molecular Mortality Non-pulmonary nonhuman immortalized cell lines Novel coronavirus novel coronavirus disease physiological question Remdesivir Replication respiratory respiratory distress SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe respiratory distress Spread Support treatments for COVID-19 virus while Wuhan Wuhan, China [DOI] 10.1371/journal.ppat.1009225 PMC 바로가기 [Article Type] Review
Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitroIota-carrageenan은 SARS-CoV-2를 중화하고 시험관 내에서 바이러스 복제를 억제합니다Research Article Published on 2021-02-172022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 진단, 치료제, [키워드] absence acute respiratory syndrome administration attachment caused cell entry clinical effectiveness common cold competent coronavirus demonstrated dose duration of symptom effective Endemic in vitro in vitro data inhibit iota-carrageenan lentivirus nasal Nasal spray neutralize neutralized Particle Patient Prophylactic Prophylaxis pseudotyped public health threat reduction Replication respiratory respiratory viruses Safe SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2 spike pseudotyped lentivirus SARS-CoV-2 virus Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus severity spike glycoprotein the cell the SARS-CoV-2 therapeutic translated Treatment Vaccine viral replication wild type [DOI] 10.1371/journal.pone.0237480 PMC 바로가기 [Article Type] Research Article
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTPfavipiravir-RTP 존재 시 SARS-CoV-2 RNA 의존성 RNA 중합효소의 구조407 Published on 2021-02-162022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved bind binding binding pocket catalytic site clinical trial clinical trials complex conformation coronavirus COVID-19 pandemic cryoEM determine determined by develop drug Drug administration drug design drugs targeting effort enzyme Evidence explain Favipiravir FDA food help incorporation Infection information inhibitor Ion ions mechanism mechanism of action molecular basis nucleoside nucleoside analog nucleotide nucleotides polymerase polymerases RdRP Remdesivir Replication respiratory reveal RNA RNA polymerase RNA polymerase inhibitor RNA primer RNA-dependent RNA polymerase SARS coronaviruses SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus side chains Significance structural biology Structure suppresse T-705 Template the SARS-CoV-2 Treatment triphosphate US Food and Drug Administration Viral while [DOI] 10.1073/pnas.2021946118 PMC 바로가기 [Article Type] 407
Early detection of neutralizing antibodies against SARS-CoV-2 in COVID-19 patients in Thailand태국 코로나19 환자에서 SARS-CoV-2에 대한 중화항체 조기 발견Research Article Published on 2021-02-122022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval biosafety can be used clinically collected COVID-19 patient COVID-19 symptoms detect determine Diagnosis diagnosis of SARS-CoV-2 Early detection IgG antibody IgM/ IgG antibody Indicator Infection interquartile range IQR isotype median Mild mild symptoms moderate NAb NAbs Negative predictive value neutralization activity Neutralizing antibodies neutralizing antibody offer Patient patients PCR-confirmed PCR-confirmed COVID-19 patients positive Predictive value protective immune response protective immunity real-time RT-PCR Receptor binding Receptor binding domain Result robust SARS-CoV-2 SARS-COV-2 infection sensitivity serological test severity of COVID-19 significantly higher specificity specimen surrogate viral neutralization assay sVNT Symptom symptom onset the patient Viral viral infections viral neutralization weakly positive [DOI] 10.1371/journal.pone.0246864 PMC 바로가기 [Article Type] Research Article
Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae흡입 가능한 복합 니클로사미드-리소자임 입자의 개발 및 평가: 코로나바이러스 감염 및 후유증에 대한 광범위한 스펙트럼, 환자 적응형 치료제Research Article Published on 2021-02-112022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] acquisition administration alternative antiviral efficacy approach causative agent clinical development coronavirus Coronavirus infection coronavirus strains COVID-19 pandemic demonstrated development drug drug level Dry powder inhaler endogenous protein Formulation hLYS human lysozyme Hypothesis in vitro in vivo inflammatory lung damage lower airway lung damage MERS MERS-CoV methicillin methicillin-resistance staphylococcus aureus pneumonia nasal Nasal spray nebulizer NIC niclosamide offer Particle Pneumonia primary site Protein respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 infections secondary to Spread Stage Staphylococcus aureus the disease treating COVID-19 Treatment upper and lower airways [DOI] 10.1371/journal.pone.0246803 PMC 바로가기 [Article Type] Research Article
Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors중증 COVID-19 회복기 기증자로부터 분리된 항체에 의한 다중 클론 SARS-CoV-2 중화Research Article Published on 2021-02-112022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, 진단, [키워드] analyzed anti-SARS-CoV-2 antibodies antibody Antibody Response Antibody responses antigenic antigenic stimulation approaches Author B cell B cell response B cell responses BCR binding site cloned Combination combinations contribute convalescent correlated COVID-19 Culture demonstrated Donor donors effective ELISA epitope Epitopes exhibited feature fusion germline healthy Immune cell immune cells infected cells Infection inhibited Interaction Live virus mAb mAbs majority mapped Mild molecular monoclonal antibody Mutagenesis NAb NAbs neutralization Neutralizing Neutralizing antibodies neutralizing antibody neutralizing response Pathogenesis pathogenesis of COVID-19 Patient peptide performed plasma IgG post infection precursor precursors Prevent produced protective immunity RBD receptor Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2 spike Sequencing Severe case severe cases severe COVID-19 severe disease manifestations Severe infection spike Spike receptor binding domain Support syncytia formation the RBD the SARS-CoV-2 the Spike therapy titers of IgG treat two group two groups uninfected unique VH3-53 [DOI] 10.1371/journal.ppat.1009165 PMC 바로가기 [Article Type] Research Article
Cardiovascular sequalae in uncomplicated COVID-19 survivors단순하지 않은 COVID-19 생존자의 심혈관 후유증Research Article Published on 2021-02-112022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 바이오마커, 치료기술, [키워드] abnormality age Atrial fibrillation bpm bradycardia Cardiac abnormalities Cardiac abnormality cardiovascular COVID-19 COVID-19 patient detect discharge disease dysfunction ECG echocardiography electrocardiogram elevated Evidence evidence of heart rate hospital discharge Hospitalization Infarct initial screening intensive care left ventricular dysfunction magnetic resonance imaging manifestation median men Mild disease myocarditis NT-proBNP performed proportion reported Result self-limiting serum biomarker serum biomarkers serum troponin Significant sinus bradycardia subsequent Surveillance survivor Survivors to define treadmill troponin ventricular ventricular dysfunction with mild disease [DOI] 10.1371/journal.pone.0246732 PMC 바로가기 [Article Type] Research Article
Effectiveness of mid-regional pro-adrenomedullin (MR-proADM) as prognostic marker in COVID-19 critically ill patients: An observational prospective studyCOVID-19 중환자에서 예후 마커로서 중부 프로아드레노메둘린(MR-proADM)의 효과: 관찰 전향 연구Observational Study Published on 2021-02-082022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 바이오마커, 임상, [키워드] 48 hour 48 hours 95% confidence interval adjusted Admission age AUC best Biomarkers C-reactive protein cardiovascular disease characterized COVID-19 COVID-19 adult patient COVID-19 ICU-patients COVID-19 patients COVID-19-ICU-patients Critically ill CRP CRP level CRP levels cut-off D-dimer diabetes Diabetes Mellitus dying patient dying patients effective Effectiveness enrolled explain Gender group higher mortality characterized patients ICU ICU admission increase in Laboratory Laboratory test Lactate lactate dehydrogenase LDH log-rank test logistic regression model lymphocyte Lymphocytes lymphocytopenia mechanism mid-regional pro-adrenomedullin Mortality MR-proADM MR-proADM measurement non-survivor NT-pro-BNP objective Odds ratio overall mortality Patient patients PCT predict Predictive procalcitonin Prognostic marker Prospective Study receiver-operating characteristics curves Referral responsible Result significantly Support survival curve Survival curves surviving and non-surviving patients tested university hospital were measured [DOI] 10.1371/journal.pone.0246771 PMC 바로가기 [Article Type] Observational Study
Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteinsSARS-CoV-2 스파이크 단백질의 다량체화 및 글리코실화 의존성 수용체 결합Research Article Published on 2021-02-082022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, [키워드] ACE2 expression adherent Author benefit binding binding affinity bronchiolar duct bronchiolar ducts candidate cell line cell lines cells complex complex glycosylated protein COVID19 demonstrated determine domain domains fluorescent fluorescent multimeric RBD proteins glycosylated glycosylated RBD glycosylation GnTI-/- mutant cells HEK293T increase mannose mannose glycosylation MONITOR monomeric monomeric and trimeric fluorescent RBD proteins mutant cells native viruses pandemic profile profiles Protein RBD RBD protein RBD proteins Receptor binding recombinant spike proteins respiratory respiratory tissue respiratory tissues sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 spike protein Spike proteins these viruses tissues toolkit trimer trimeric trimeric fully glycosylated RBD trimers trimeric RBD protein variants virus viruses were stained zoonotic [DOI] 10.1371/journal.ppat.1009282 PMC 바로가기 [Article Type] Research Article