Linear B-Cell Epitope Prediction for In Silico Vaccine Design: A Performance Review of Methods Available via Command-Line InterfaceReview Published on 2021-03-222022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] antibody production B-cell epitope BepiPred Classifier Consensus consensus prediction method COVID-19 datasets diagnostic Disease diagnosis Epitope-based vaccine faster help Immunotherapy interface linear linear epitope methodology performance prediction predictor Research researcher review SVMTriP therapy Vaccine design Vaccines was performed while [DOI] 10.3390/ijms22063210 PMC 바로가기 [Article Type] Review
A Rapid and Efficient Screening System for Neutralizing Antibodies and Its Application for SARS-CoV-2항체 중화를 위한 신속하고 효율적인 스크리닝 시스템 및 SARS-CoV-2에 대한 적용Immunology Published on 2021-03-222022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Analysis antibody production application blood sample COVID-19 convalescent patients described Diseases domain effective efficient exhibited generate half-maximal inhibitory concentration high affinity methodology NAb NAbs Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody pandemic of COVID-19 Prophylactic provide Rapid RBD Receptor-binding domain (RBD) SARS-CoV-2 SARS-CoV-2 RBD Screening screening method Spike protein System therapeutic therapeutic purposes [DOI] 10.3389/fimmu.2021.653189 PMC 바로가기 [Article Type] Immunology
Severe Acute Respiratory Syndrome Coronavirus 2 Viral RNA Load Status and Antibody Distribution Among Patients and Asymptomatic Carriers in Central China중증 급성 호흡기 증후군 코로나 바이러스 2 바이러스 RNA 부하 상태 및 중국 중부의 환자 및 무증상 보균자 간의 항체 분포Cellular and Infection Microbiology Published on 2021-03-192022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 antibody antibody production Antibody Response Asymptomatic carrier Asymptomatic carriers carrier Chain Reaction chemiluminescence China complexity coronavirus coronavirus 2 coronavirus disease COVID-19 COVID-19 patients COVID-19 transmission Diseases healthy Hospitalized IgG IgG and IgM IgG antibodies IgM IgM/IgG Immunoglobulin indication interquartile range intestinal tract load median MONITOR Oropharyngeal Patient polymerase chain polymerase chain reaction positive recovered patient recovered patients respiratory respiratory viral response rates RNA SARS-CoV-2 SARS-CoV-2 IgM SARS-CoV-2 RNA serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severely ill COVID-19 patients specific serum sputum status Stool stool samples Symptom symptom onset tested throat swabs Viral Viral load viral loads Viral RNA viral RNA load [DOI] 10.3389/fcimb.2021.559447 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
SARS-CoV-2 Infection and Inflammatory Response in a Twin Pregnancy쌍둥이 임신의 SARS-CoV-2 감염 및 염증 반응Case Reports Published on 2021-03-172022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] abortion Analysis antibody production changes in Complication Concentration COVID-19 cytokine Cytokine storm Cytokines defined described diagnosed during pregnancy Dysbiosis Effect Evidence expressed fetal fetus G-CSF genital tract microbiome gestation healthy Hospitalization host susceptibility IL-12 IL-8 IL-9 immune system Immunological response infected patients Infection infections Infectious disease Infectious diseases Inflammatory response intensive care intensive care unit lead marker Microbiome microbiome composition Mortality Neonatal pattern placental pregnancies Pregnancy pregnant women Premature premature birth Preterm birth preterm labor producing response risk SARS-CoV-2 SARS-COV-2 infection spontaneous abortion susceptibility tested the SARS-CoV-2 tissue tissue tropism Transmission twin twin pregnancy vertical transmission virus with infection [DOI] 10.3390/ijerph18063075 PMC 바로가기 [Article Type] Case Reports
SARS-CoV-2-induced humoral immunity through B cell epitope analysis in COVID-19 infected individuals코로나19 감염자의 B세포 에피토프 분석을 통한 SARS-CoV-2 유도 체액성 면역Article Published on 2021-03-152022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료제, [키워드] adaptive Adaptive immunity Analysis antibody production Antibody titer B cell B cell epitope B cell epitopes city coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infected individual COVID-19 patient COVID-19 patients domain elevated ELISA epitope Epitopes hot spots Humoral immunity IgG IgM Immunity immunology individual Individual differences Infection intensive care intensive care unit linear linear B MOST N-terminal domain Neutralizing activity Neutralizing antibody titer Patient patients predicted pseudotype pseudotype virus RBD Receptor-binding domain S protein SARS-CoV-2 serum spike glycoprotein the S protein the vaccine university Vaccine development virus-neutralizing [DOI] 10.1038/s41598-021-85202-9 PMC 바로가기 [Article Type] Article
Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidatesArticle Published on 2021-03-112022-10-04 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, [키워드] absence added Analysis antibody production Antibody-dependent enhancement applied B cell response B cell responses BALB/c mice candidate candidate vaccine caused COVID-19 outbreak Diseases effective Efficacy Efficacy and safety GM-CSF Health humanized immunology in vitro in vivo inactivated Inactivated vaccine infective mice Microbiology morbidity and mortality neutralization capacity Pathogenesis peptide pool performed Preclinical reducing reported SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 virus T cell T cell response the vaccine Toxicity Vaccine vaccine candidate virus [DOI] 10.1038/s41598-021-83930-6 PMC 바로가기 [Article Type] Article
Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS‑CoV-2 infection경도 SARS-CoV-2 감염에 대한 항체 반응의 이질성 및 혈청 역전의 시계열 분석 및 기계론적 모델링Research Paper Published on 2021-03-022022-09-11 Journal: EBioMedicine [Category] SARS, 진단, 치료법, [키워드] Analysis Anti-S1 antibody antibody levels antibody production Antibody Response antibody titres assays Asymptomatic Blood blood sampling changes in clearance Comparisons correlated deaths evaluate Extended faster finding Follow-up funding greater healthcare worker heterogeneity heterogeneous Humoral immunity identify IgG Infection infections London Longevity Longitudinal studies longitudinal study Mathematical modelling mechanism median Mild mild infection mild SARS-CoV-2 infection neutralising antibody titre NIHR participant PCR peak population level positive production rate prospective cohort study protective humoral immunity pseudovirus pseudovirus neutralizing antibody recruited reduction in reductions in required response Roche S1 domain SARS-CoV-2 SARS-CoV-2 epidemic SARS-COV-2 infection SARS-CoV-2, Serology, Mathematical modelling, Sero-reversion semi-quantitative serological analysis serological response serology sustained Symptom time transition Viral viral nucleocapsid protein viral spike was performed Wellcome Trust [DOI] 10.1016/j.ebiom.2021.103259 PMC 바로가기 [Article Type] Research Paper
What do we know about the antibody responses to SARS-CoV-2?SARS-CoV-2에 대한 항체 반응에 대해 무엇을 알고 있습니까?Review Published on 2021-03-012022-09-12 Journal: Immunobiology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome Adaptive immune response antibody antibody production convalescent patient convalescent plasma coronavirus COVID-19 deaths develop highlight Humoral response Immunity pandemic plasma SARS-CoV-2 SARS-COV-2 infection Scientific community Seroconversion Spread the antibody response Therapies Treatment Vaccine [DOI] 10.1016/j.imbio.2021.152054 PMC 바로가기 [Article Type] Review
Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients중증 COVID-19 환자에서 자가포식 마커의 발현 감소 및 골수 유래 억제 세포의 확장은 불량한 T 세포 반응과 상관관계가 있습니다Immunology Published on 2021-02-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, 진단, [키워드] accumulation Activation Affect Analysis analyzed antibody production autophagy B cell B cells CD4+ T cell Cell cellular cellular and humoral immune response coronavirus coronavirus disease Coronavirus Disease (COVID)-19 correlated correlation COVID-19 COVID-19 pathogenesis COVID-19 patient Critical Cytokines dendritic cell dendritic cells diagnostics disease dominant down-regulated driving dysregulated immune response ELISA expansion expression expressions flow-cytometry followed by functional healthy donor HLA-DR humoral immune response iCoS IFN-γ IL-10 IL-6 immune response immunological mechanism implication Inflammation interferon Laboratory parameters lymphocytopenia mild COVID-19 patient mild COVID-19 patients Monocytes multiorgan failure myeloid-derived suppressor cells NKT cells parameter PD-L1 Peripheral blood Pneumonia Poor quantitative PCR Regulatory regulatory lymphocytes respiratory response severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient severe patients significantly subset suppressor suppressor cells susceptible individuals T cell T cell response T cell subset T cells western blot [DOI] 10.3389/fimmu.2021.614599 PMC 바로가기 [Article Type] Immunology
Dysregulated transcriptional responses to SARS-CoV-2 in the periphery말초에서 SARS-CoV-2에 대한 조절되지 않은 전사 반응Article Published on 2021-02-172022-09-10 Journal: Nature Communications [Category] MERS, 유전자 메커니즘, 진단, 치료기술, [키워드] Activation antibody production approach AUROC B-cell Bacterial bacterial pneumonia classifiers clinical manifestation clinical manifestations Coagulation component components conserved coronavirus COVID-19 Diagnosis differentially expressed gene Differentially expressed genes disease dysregulated dysregulated immune response dysregulated immune responses expression feature fibrinolytic healthy healthy controls heterogeneous host response hosts illness immune immune response immune responses Infection Infectious-disease diagnostics Influenza interferon JAK/STAT signaling other respiratory infection other respiratory infections pathway Pathways Peripheral blood peripheral blood samples Pneumonia provide respiratory respiratory infections response reveal RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing shown STAT subject transcriptional response Transcriptome transcriptomic Trigger triggers unique viral infection with COVID-19 [DOI] 10.1038/s41467-021-21289-y PMC 바로가기 [Article Type] Article