Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study인간 코로나바이러스 OC43 스파이크 단백질에 대한 교차 반응성 항체는 COVID-19 환자의 질병 중증도와 상관관계가 있습니다: 후향적 연구Research Article Published on 2021-04-022022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술, [키워드] age antibody Antibody titre antigenic change collected correlated correlation correlations COVID-19 COVID-19 pathogenesis COVID-19 patients cross-reactive antibody cross-reactivity detectable disease severity evaluated HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoV-OC43 spike HCoVs healthy control healthy controls HKU1 human coronavirus human coronavirus OC43 human populations humoral Humoral response IgG IgG antibody mechanical ventilation mild patient mild patients mounted Neutralizing antibodies NL63 OC43 Pathogenesis Patient plasma sample plasma samples positive Protein PSO Retrospective study S protein SARS-CoV-2 seasonal severe disease severity significant increase significantly higher Spike protein Spike proteins Spread symptom onset tested the disease titre [DOI] 10.1080/22221751.2021.1905488 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study국가 covid-19 혈청유병률 조사에 사용 가능한 SARS-CoV-2 측면 흐름 분석(React 2): 진단 정확도 연구Research Published on 2021-03-022022-09-10 Journal: The BMJ [Category] Fulltext, SARS, 진단, 치료기술, [키워드] 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis antibody Antibody titre antibody titres antigen binding antigen binding assay clinical sample Clinical use clinics cohorts college community transmission coronavirus coronavirus disease Coronavirus disease 2019 diagnostic Diagnostic accuracy enzyme evaluate evaluated finger Finger prick IgG immunoassay Immunoglobulin Immunoglobulin G Inclusion Infection Laboratory laboratory analyses Laboratory analysis lateral flow lateral flow immunoassay LFIA LFIAs London lowest minimum National NHS objective outcome measure PanBio participant performed positive sample real time Reference standards respiratory Result SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity analyses Sensitivity and specificity sera seroprevalence survey serum serum sample serum samples setting Seven significantly higher Spike protein Surescreen tested titre United Kingdom were used [DOI] 10.1136/bmj.n423 PMC 바로가기 [Article Type] Research
Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021Rapid Communication Published on 2021-02-112022-10-31 Journal: Eurosurveillance [Category] COVID-19, Fulltext, MERS, [키워드] age Antibody titre BNT162b2 mRNA clinical trial COVID-19 COVID-19 infection COVID-19 vaccine detectable Efficacy Evidence healthcare IgG antibody immunogenicity Impact Infection Israel Israeli healthcare worker magnitude naïve individual Observational data Population pre-vaccination Sex single dose Trial Vaccine [DOI] 10.2807/1560-7917.ES.2021.26.6.2100096 PMC 바로가기 [Article Type] Rapid Communication
Correlates of protection against SARS-CoV-2 in rhesus macaques붉은 털 원숭이에서 SARS-CoV-2에 대한 보호 상관 관계Article Published on 2021-02-012022-09-12 Journal: Nature [Category] MERS, SARS, 진단, [키워드] abrogated acute respiratory syndrome Antibody Response Antibody titre antibody titres CD8 Cellular immune response cellular immunity contribute convalescent coronavirus Depletion dose-dependent Efficacy humoral IgG Immunity implication infection with SARS-CoV-2 macaque macaques natural immunity PROTECT Protective purified recent reported required rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine T cell therapeutic agents transfer Treatment [DOI] 10.1038/s41586-020-03041-6 PMC 바로가기 [Article Type] Article
Hepatitis B surface antibody titres and hepatitis B reactivation with direct-acting antiviral therapy for hepatitis CArticle Published on 2021-02-012023-06-12 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Antibody titre direct-acting antiviral therapy HBsAb HBV reactivation hepatitis C [DOI] 10.1111/jvh.13421
Neutralizing antibody titres in SARS-CoV-2 infectionsSARS-CoV-2 감염에서 항체 역가 중화Observational Study Published on 2021-01-042022-09-10 Journal: Nature Communications [Category] 임상, 진단, 치료기술, [키워드] antibody Antibody responses Antibody titre assays asymptomatic infection asymptomatic infections asymptomatic patients Chain Reaction Cohort collected decrease Detection limit disease elicit endpoints global public health individuals initial Kinetics Medical research Mild mild or asymptomatic infections neutralization Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody titre neutralizing antibody titres onset of symptom onset of symptoms Patient persist plaque reduction neutralization polymerase chain polymerase chain reaction PRNT remained responses reverse transcription reverse transcription polymerase chain reaction robust RT-PCR RT-PCR detection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic sera seropositive Serum neutralizing antibody severe disease severity specific neutralizing antibody tested titre virus [DOI] 10.1038/s41467-020-20247-4 PMC 바로가기 [Article Type] Observational Study
Clinical predictors of donor antibody titre and correlation with recipient antibody response in a COVID‐19 convalescent plasma clinical trialOriginal Article Published on 2020-11-032023-06-14 Journal: Journal of Internal Medicine [Category] MERS, SARS, [키워드] Antibody titre convalescent plasma COVID‐19 [DOI] 10.1111/joim.13185 PMC 바로가기 [Article Type] Original Article
Convalescent plasma transfusion therapy in severe COVID-19 patients- a safety, efficacy and dose response study: A structured summary of a study protocol of a phase II randomized controlled trial중증 COVID-19 환자의 회복기 혈장 수혈 요법- 안전성, 효능 및 용량 반응 연구: 2상 무작위 대조 시험 연구 프로토콜의 구조화된 요약Letter Published on 2020-10-262022-08-13 Journal: Trials [Category] MERS, SARS, 임상, [키워드] (neutrophil 24 hour 24 hours allergic allergic reaction Antibody titre Arm ARMS automated blinded Blinding body temperature BSMMU Care checked Clinical improvement collaboration collected comparator computer Controlled Controlled trial convalescent plasma COVID-19 creatinine criteria CRP CT scan deaths defined diastolic discharge dissemination Donor donors dose dose response effective effective dose Efficacy Efficacy and safety element ELISA end point enrolled Evidence evidence of excluded expected FiO2 generate Health Organization hospital Hospital stay ICU identify in-hospital mortality inclusion criteria initial intervention arms Laboratory laboratory parameter Laboratory parameters Laboratory tests lactating women lung lymphocyte multi-arm multicentre neutralizing antibody neutrophil normality number objective open outcome Oxford oxygen oxygen saturations PaO2 paO2/fiO2 participant Participants Patient PCR assay performed plasma Plasma transfusion positive pregnant Primary outcome proportion protocol random number table randomised Randomized controlled trial RCT receive recorded recording recruit recruited recruitment reduction in required respiratory respiratory distress respiratory rate respiratory symptoms room air RT-PCR RT-PCR assay Sample size sample size calculation SARS-CoV-2 secondary outcome serum creatinine Serum ferritin Seven Severe case severe cases severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient severe patients Severe respiratory distress Sex SGOT SGPT SpO2 sputum standard care status Study protocol Support systolic the patient therapy These data titre transfusion Treatment Trial university University of Oxford ventilator website World Health Organization X-ray [DOI] 10.1186/s13063-020-04734-z PMC 바로가기 [Article Type] Letter
Adaptive immunity to SARS-CoV-2Review Article Published on 2020-07-092022-10-29 Journal: Oxford Open Immunology [Category] COVID-19, [키워드] absence Activation acute infection acute respiratory syndrome Adaptive immunity antibody Antibody Response Antibody titre blood vessels CD4 CD8 Clinical use common cold coronavirus Correlate of protection Course COVID-19 cross-reactivity Cytokines detectable disease disease severity duration of exposure epitope Evidence expression full recovery functional human coronavirus human coronaviruses Hyperinflammatory IL-6 immune memory immunogenic immunology immunopathological immunopathology individual Infection kidney lung majority mechanism neutralizing antibody neutralizing monoclonal antibody offer Pathogenesis Protective question raised rapid progress response SARS-CoV-2 serum biomarker severe cases susceptibility symptomatic disease Symptoms T cell T-cell T-cell immunity therapeutic target tissue damage Vaccine viral antigens Viral load Virus neutralization while [DOI] 10.1093/oxfimm/iqaa003 PMC 바로가기 [Article Type] Review Article
Secondary tension pneumothorax in a COVID-19 pneumonia patient: a case reportCOVID-19 폐렴 환자의 이차 긴장성 기흉: 증례 보고Case Reports Published on 2020-06-182022-09-10 Journal: Infection [Category] MERS, SARS, 바이오마커, [키워드] (Polymerase Chain Reaction Antibody titre Azithromycin breath Case report Chain Reaction Chest complications Computed tomography consolidation consolidations coronavirus disease Coronavirus disease 2019 coughing COVID-19 COVID-19 patient COVID-19 patients develop discharged distribution dry cough Dyspnoea emergency department Evidence Fever IgG antibody Level male Multidetector computed tomography Negative pressure Non-invasive open thoracotomy Oxygenation Patient patients PCR physician Pneumonia Pneumothorax polymerase chain polymerase chain reaction positive pulmonary complication pulmonary complications recent Regression Relieved by reported SARS-CoV-2 SARS-COV-2 infection secondary severe pneumonia sore throat sputum supplementary material supportive therapy tension tension pneumothorax the patient therapy treating Treatment viral infections [DOI] 10.1007/s15010-020-01457-w PMC 바로가기 [Article Type] Case Reports